The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Mussel‐Inspired Contact‐Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability
Abstract
Antibacterial hydrogel has received extensive attention in soft tissue repair, especially preventing infections those associated with impaired wound healing. However, it is challenging in developing an inherent antibacterial hydrogel integrating with excellent cell affinity and superior mechanical properties. Inspired by the mussel adhesion chemistry, a contact‐active antibacterial hydrogel is proposed by copolymerization of methacrylamide dopamine (MADA) and 2‐(dimethylamino)ethyl methacrylate and forming an interpenetrated network with quaternized chitosan. The reactive catechol groups of MADA endow the hydrogel with contact intensified bactericidal activity, because it increases the exposure of bacterial cells to the positively charged groups of the hydrogel and strengthens the bactericidal effect. MADA also maintains the good adhesion of fibroblasts to the hydrogel. Moreover, the hybrid chemical and physical cross‐links inner the hydrogel network makes the hydrogel strong and tough with good recoverability. In vitro and in vivo tests demonstrate that this tough and contact‐active antibacterial hydrogel is a promising material to fulfill the dual functions of promoting tissue regeneration and preventing bacterial infection for wound‐healing applications.
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Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity
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Mussel-Inspired Adhesive and Tough Hydrogel Based on Nanoclay Confined Dopamine Polymerization
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Self-citationA polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
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Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Gan, D., Xing, W., Jiang, L., Fang, J., Zhao, C., Ren, F., Fang, L., Wang, K., & Lu, X. (2019) · Nature Communications · doi:10.1038/s41467-019-09351-2 · Cited by 1,029
Self-citationLu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Mussel-inspired hydrogels: From design principles to promising applications
Zhang, C., Wu, B., Zhou, Y., Zhou, F., Liu, W., & Wang, Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00849g · Cited by 653
Metadata
- Authors
- Gan, D., Xu, T., Xing, W., Ge, X., Fang, L., Wang, K., Ren, F., & Lu, X.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2018-11-13
- Volume
- 29
- Issue
- 1
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2900540898
- Cited by
- 425
- References
- 36
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gan, D., Xu, T., Xing, W., Ge, X., Fang, L., Wang, K., Ren, F., & Lu, X. (2019). Mussel‐Inspired Contact‐Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability. Advanced Functional Materials. https://doi.org/10.1002/adfm.201805964
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