The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing
Abstract
The design and development of a smart bioadhesive hydrogel sealant with self-healing and excellent antibacterial activity to achieve high wound closure effectiveness and post-wound-closure care is highly desirable in clinical applications. In this work, a series of adhesive antioxidant antibacterial self-healing hydrogels with promising traits were designed through dual-dynamic-bond cross-linking among ferric iron (Fe), protocatechualdehyde (PA) containing catechol and aldehyde groups and quaternized chitosan (QCS) to enable the closure of skin incisions and promotion of methicillin-resistant Staphylococcus aureus (MRSA)-infected wound healing. The dual-dynamic-bond cross-linking of a pH-sensitive coordinate bond (catechol–Fe) and dynamic Schiff base bonds with reversible breakage and re-formation equips the hydrogel with excellent autonomous healing and on-demand dissolution or removal properties. Additionally, the hydrogel presents injectability, good biocompatibility and antibacterial activity, multifunctional adhesiveness, and hemostasis as well as NIR responsiveness. The in vivo evaluation in a rat skin incision model and infected full-thickness skin wound model revealed the high wound closure effectiveness and post-wound-closure care of the smart hydrogels, demonstrating its great potential in dealing with skin incisions and infected full-thickness skin wounds.
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Self-citationZhao, X., Guo, B., Wu, H., Liang, Y., & Ma, P. X. (2018) · Nature Communications · doi:10.1038/s41467-018-04998-9 · Cited by 1,161
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A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
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Self-citationToughening elastomers using mussel-inspired iron-catechol complexes
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Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement
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Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Self-citationPreparation and application of pH-responsive drug delivery systems
Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.056 · Cited by 645
Yang, Y., Liang, Y., Chen, J., Duan, X., & Guo, B. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.014 · Cited by 548
Self-citationQi, X., Huang, Y., You, S., Xiang, Y., Cai, E., Mao, R., Pan, W., Tong, X., Dong, W., Ye, F., et al. (2022) · Advanced Science · doi:10.1002/advs.202106015 · Cited by 519
Self-citationLiang, Y., Xu, H., Li, Z., Zhangji, A., & Guo, B. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00928-z · Cited by 313
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Metadata
- Authors
- Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-03-25
- Volume
- 15
- Issue
- 4
- Pages
- 7078-7093
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3139239834
- Cited by
- 1,083
- References
- 71
- FWCI
- 83.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021). Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing. ACS Nano. https://doi.org/10.1021/acsnano.1c00204
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