The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery
Abstract
Stimuli‐sensitive synthetic polypeptides are unique biodegradable and biocompatible synthetic polymers with structures mimicking natural proteins. These polymers exhibit reversible secondary conformation transitions and/or hydrophilic–hydrophobic transitions in response to changes in environmental conditions such as pH and temperature. The stimuli‐triggered conformation and/or phase transitions lead to unique self‐assembly behaviors, making these materials interesting for controlled drug and gene delivery applications. Therefore, stimuli‐sensitive synthetic polypeptide‐based materials have been extensively investigatid in recent years. Various polypeptide‐based materials, including micelles, vesicles, nanogels, and hydrogels, have been developed and tested for drug‐ and gene‐delivery applications. In addition, the presence of reactive side groups in some polypeptides facilitates the incorporation of various functional moieties to the polypeptides. This Review focuses on recent advances in stimuli‐sensitive polypeptide‐based materials that have been designed and evaluated for drug and gene delivery applications. In addition, recent developments in the preparation of stimuli‐sensitive functionalized polypeptides are discussed.
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Cites
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Polymersomes: Tough Vesicles Made from Diblock Copolymers
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Cited by
Biopolymer-based functional composites for medical applications
Park, S.-B., Lih, E., Park, K.-S., Joung, Y. K., & Han, D. K. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.12.003 · Cited by 429
Deng, C., Wu, J., Cheng, R., Meng, F., Klok, H.-A., & Zhong, Z. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.10.008 · Cited by 371
Advances in biodegradable and injectable hydrogels for biomedical applications
Li, Y., Yang, H. Y., & Lee, D. S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.008 · Cited by 261
Articular cartilage repair biomaterials: strategies and applications
Wang, M., Wu, Y., Li, G., Lin, Q., Zhang, W., Liu, H., & Su, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100948 · Cited by 145
Computational amphiphilic materials for drug delivery
Thota, N., & Jiang, J. (2015) · Frontiers in Materials · doi:10.3389/fmats.2015.00064 · Cited by 38
Metadata
- Authors
- He, C., Zhuang, X., Tang, Z., Tian, H., & Chen, X.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2011-12-05
- Volume
- 1
- Issue
- 1
- Pages
- 48-78
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2061208808
- Cited by
- 337
- References
- 214
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- He, C., Zhuang, X., Tang, Z., Tian, H., & Chen, X. (2012). Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201100008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
