Thermosensitive sol-gel reversible hydrogels
Abstract
Aqueous polymer solutions that are transformed into gels by changes in environmental conditions, such as temperature and pH, thus resulting in in situ hydrogel formation, have recently attracted the attention of many investigators for scientific interest and for practical biomedical or pharmaceutical applications. When the hydrogel is formed under physiological conditions and maintains its integrity for a desired period of time, the process may provide various advantages over conventional hydrogels. Because of the simplicity of pharmaceutical formulation by solution mixing, biocompatibility with biological systems, and convenient administration, the pharmaceutical and biomedical uses of the water-based sol-gel transition include solubilization of low-molecular-weight hydrophobic drugs, controlled release, labile biomacromolecule delivery, such as proteins and genes, cell immobilization, and tissue engineering. When the formed gel is proven to be biocompatible and biodegradable, producing non-toxic degradation products, it will provide further benefits for in vivo applications where degradation is desired. It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects. This review stresses the polymeric systems of natural or modified natural polymers, N-isopropylacrylamide copolymers, poly(ethylene oxide)/poly(propylene oxide) block copolymers, and poly(ethylene glycol)/poly(D,L-lactide-co-glycolide) block copolymers.
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Thermo-responsive polymers show sol-gel transitions with a change in external temperature, and hydrogels made of thermoresponsive polymers find drug delivery applications through simple chemical modifications.
“Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [30]
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- Authors
- Jeong, B., Kim, S. W., & Bae, Y. H.
- Affiliations
- Pacific Northwest National Laboratory (US)
- University of Utah (US)
- Corresponding author
- Bae, You Han
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 54
- Issue
- 1
- Pages
- 37-51
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1966590541
- Cited by
- 1,478
- References
- 96
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 25 · 2023: 31 · 2022: 40 · 2021: 62 · 2020: 66 · 2019: 68 · 2018: 74 · 2017: 66 · 2016: 84 · 2015: 84 · 2014: 86 · 2013: 86 · 2012: 102
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- thermosensitive hydrogel, sol-gel transition, thermoresponsive polymers, N-isopropylacrylamide copolymers, poly(ethylene oxide)-poly(propylene oxide) block copolymers, controlled drug release, cell immobilization, tissue engineering, biodegradable polymers, hydrophobic drug solubilization, in situ gelation
- MeSH terms
- Hydrogen-Ion Concentration, Polymers, Temperature, Drug Delivery Systems, Hydrogels, Tissue Engineering
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