Well‐Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Chen, Chih‐Kuang; Law, Wing‐Cheung; Aalinkeel, Ravikumar; Nair, Bindukumar; Kopwitthaya, Atcha; Mahajan, Supriya D.; Reynolds, Jessica L.; Zou, Jiong; Schwartz, Stanley A.; Prasad, Paras N.; Cheng, Chong

doi:10.1002/adhm.201200094

Well‐Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Well‐defined tertiary amine‐functionalized cationic polylactides (CPLAs) are synthesized by thiol‐ene click functionalization of an allyl‐functionalized polylactide, and utilized for the delivery of interleukin‐8 (IL‐8) siRNA via CPLA‐IL‐8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic…