The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Smart pH‐Responsive Nanocarriers Based on Nano‐Graphene Oxide for Combined Chemo‐ and Photothermal Therapy Overcoming Drug Resistance
Abstract
A pH‐responsive nanocarrier is developed by coating nanoscale graphene oxide (NGO) with dual types of polymers, polyethylene glycol (PEG) and poly(allylamine hydrochloride) (PAH), the latter of which is then modified with 2,3‐dimethylmaleic anhydride (DA) to acquire pH‐dependent charge reversibility. After loading with doxorubicin (DOX), a chemotherapy drug, the obtained NGO‐PEG‐DA/DOX complex exhibits a dual pH‐responsiveness, showing markedly enhanced cellular uptake under the tumor microenvironmental pH, and accelerated DOX release under a further lowered pH inside cell lysosomes. Combining such a unique behavior with subsequently slow efflux of DOX, NGO‐PEG‐DA/DOX offers remarkably improved cell killing for drug‐resistant cancer cells under the tumor microenvironmental pH in comparison with free DOX. Exploiting its excellent photothermal conversion ability, combined chemo‐ and photothermal therapy is further demonstrated using NGO‐PEG‐DA/DOX, realizing a synergistic therapeutic effect. This work presents a novel design of surface chemistry on NGO for the development of smart drug delivery systems responding to the tumor microenvironment and external physical stimulus, with the potential to overcome drug resistance.
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Citations
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Cited by
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Sahandi Zangabad, P., Rahighi, R., Moosavi Basri, S. M., Mirshekari, H., Amiri, M., Shafaei Pishabad, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,519
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2018) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 426
Self-citationYu, X., Li, A., Zhao, C., Yang, K., Chen, X., & Li, W. (2017) · ACS Nano · doi:10.1021/acsnano.7b00476 · Cited by 339
Liu, J., Luo, Z., Zhang, J., Luo, T., Zhou, J., Zhao, X., & Cai, K. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.008 · Cited by 294
Self-citationHuang, J., Li, Y., Orza, A., Lu, Q., Guo, P., Wang, L., Yang, L., & Mao, H. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504185 · Cited by 292
Metadata
- Authors
- Feng, L., Li, K., Shi, X., Gao, M., Liu, J., & Liu, Z.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2014-03-20
- Volume
- 3
- Issue
- 8
- Pages
- 1261-1271
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2082897067
- Cited by
- 171
- References
- 2
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feng, L., Li, K., Shi, X., Gao, M., Liu, J., & Liu, Z. (2014). Smart pH‐Responsive Nanocarriers Based on Nano‐Graphene Oxide for Combined Chemo‐ and Photothermal Therapy Overcoming Drug Resistance. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201300549
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