Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine
Open accessAbstract
Current clinically applicable tissue and organ replacement therapies are limited in the field of cardiovascular regenerative medicine. The available options do not regenerate damaged tissues and organs, and, in the majority of the cases, show insufficient restoration of tissue function. To date, anticoagulant drug‐free heart valve replacements or growing valves for pediatric patients, hemocompatible and thrombus‐free vascular substitutes that are smaller than 6 mm, and stem cell‐recruiting delivery systems that induce myocardial regeneration are still only visions of researchers and medical professionals worldwide and far from being the standard of clinical treatment. The design of functional off‐the‐shelf biomaterials as well as automatable and up‐scalable biomaterial processing methods are the focus of current research endeavors and of great interest for fields of tissue engineering and regenerative medicine. Here, various approaches that aim to overcome the current limitations are reviewed, focusing on biomaterials design and generation methods for myocardium, heart valves, and blood vessels. Furthermore, novel contact‐ and marker‐free biomaterial and extracellular matrix assessment methods are highlighted.
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Incorporating different proportions of other materials into PLCL matrix improves mechanical strength to meet heart valve needs.
“the researchers formed the new composite material by incorporating different proportions of other materials into the PLCL matrix to improve the mechanical strength of the material so that it can meet the needs of the heart valve [149, 171].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [149]
The section “Biomaterials Used for Heart Valve Tissue Engineering” describes combining PGS and PCL in a scaffold with good mechanical properties for heart-valve applications (page unavailable). It does not describe adding materials in different proportions to a PLCL matrix or show that this improves its mechanical strength. (LLM, conf=0.86)
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Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
“Vascular grafts need to withstand the impact of blood fl ow and the extrusion and traction from surrounding tissues in the physiological state, so they need to have certain mechanical properties such as tensile properties and elongation at break, and adequate anti-fracture strength [149].”
- Authors
- Hinderer, S., Brauchle, E., & Schenke‐Layland, K.
- Affiliations
- Fraunhofer Institute for Interfacial Engineering and Biotechnology (DE)
- University of Stuttgart (DE)
- University of California, Los Angeles (US)
- Corresponding author
- Schenke‐Layland, Katja
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2015-03-16
- Volume
- 4
- Issue
- 16
- Pages
- 2326-2341
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC4745029
- OpenAlex
- W2084208482
- Cited by
- 68
- References
- 197
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advanced Healthcare Materials (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Funders
- Fraunhofer IGB Stuttgart and the Medical Faculty of the Eberhard Karls University Tübingen
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- biomaterial scaffolds, cardiovascular tissue engineering, regenerative medicine, heart valve replacement, vascular replacement, cardiac regeneration, stem cell delivery, biomaterial design
- MeSH terms
- Biocompatible Materials, Cardiovascular System, Humans, Wound Healing, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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