The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering
Abstract
For the first time, electrospun polycaprolactone (PCL) 3D nanofibrous scaffold has been developed by an innovative and convenient approach (i.e., thermally induced nanofiber self‐agglomeration followed by freeze drying), and the scaffold possesses interconnected and hierarchically structured pores including macropores with sizes up to ≈300 μm. The novel PCL 3D scaffold is soft and elastic with very high porosity of ≈96.4%, thus it is morphologically/structurally similar to natural extracellular matrix and well suited for cell functions and tissue formation. The in vitro studies reveal that the scaffold can lead to high cell viability; more importantly, it is able to promote more potent BMP2‐induced chondrogenic than osteogenic differentiation of mouse bone marrow mesenchymal stem cells. Consistent to the in vitro findings, the in vivo results indicate that the electrospun PCL 3D scaffold acts as a favorable synthetic extracellular matrix for functional bone regeneration through the physiological endochondral ossification process.
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Cites
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Cited by
Electrospun nanofiber reinforced composites: a review
Jiang, S., Chen, Y., Duan, G., Mei, C., Greiner, A., & Agarwal, S. (2018) · Polymer Chemistry · doi:10.1039/c8py00378e · Cited by 560
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Self-citationBone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds
Koushik, T. M., Miller, C. M., & Antunes, E. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202766 · Cited by 359
Polymer-based composites by electrospinning: Preparation & functionalization with nanocarbons
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Progress in 3D-MXene Electrodes for Lithium/Sodium/Potassium/Magnesium/Zinc/Aluminum-Ion Batteries
Bashir, T., Zhou, S., Yang, S., Ismail, S. A., Ali, T., Wang, H., Zhao, J., & Gao, L. (2023) · Electrochemical Energy Reviews · doi:10.1007/s41918-022-00174-2 · Cited by 284
Metadata
- Authors
- Xu, T., Miszuk, J. M., Zhao, Y., Sun, H., & Fong, H.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2015-09
- Volume
- 4
- Issue
- 15
- Pages
- 2238-2246
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W1506424806
- Cited by
- 282
- References
- 41
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, T., Miszuk, J. M., Zhao, Y., Sun, H., & Fong, H. (2015). Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201500345
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