The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC‐Derived Endothelial Cells
Open accessAbstract
Vascularization of engineered human skin constructs is crucial for recapitulation of systemic drug delivery and for their long‐term survival, functionality, and viable engraftment. In this study, the latest microfabrication techniques are used and a novel bioengineering approach is established to micropattern spatially controlled and perfusable vascular networks in 3D human skin equivalents using both primary and induced pluripotent stem cell (iPSC)‐derived endothelial cells. Using 3D printing technology makes it possible to control the geometry of the micropatterned vascular networks. It is verified that vascularized human skin equivalents (vHSEs) can form a robust epidermis and establish an endothelial barrier function, which allows for the recapitulation of both topical and systemic delivery of drugs. In addition, the therapeutic potential of vHSEs for cutaneous wounds on immunodeficient mice is examined and it is demonstrated that vHSEs can both promote and guide neovascularization during wound healing. Overall, this innovative bioengineering approach can enable in vitro evaluation of topical and systemic drug delivery as well as improve the potential of engineered skin constructs to be used as a potential therapeutic option for the treatment of cutaneous wounds.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials · doi:10.1038/nmat3357 · Cited by 1,917
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872
Bioengineering Dermo-Epidermal Skin Grafts with Blood and Lymphatic Capillaries
Marino, D., Luginbühl, J., Scola, S., Meuli, M., & Reichmann, E. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006894 · Cited by 242
Itoh, M., Umegaki-Arao, N., Guo, Z., Liu, L., Higgins, C. A., & Christiano, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077673 · Cited by 239
Self-citationGledhill, K., Guo, Z., Umegaki-Arao, N., Higgins, C. A., Itoh, M., & Christiano, A. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136713 · Cited by 132
Self-citationUmegaki-Arao, N., Pasmooij, A. M. G., Itoh, M., Cerise, J. E., Guo, Z., Levy, B., Gostyński, A., Rothman, L. R., Jonkman, M. F., & Christiano, A. M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009342 · Cited by 123
Self-citation
Cited by
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Song, H.-H. G., Rumma, R. T., Ozaki, C. K., Edelman, E. R., & Chen, C. S. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.009 · Cited by 476
Tissue engineering of human hair follicles using a biomimetic developmental approach
Abaci, H. E., Coffman, A., Doucet, Y., Chen, J., Jacków, J., Wang, E., Guo, Z., Shin, J. U., Jahoda, C. A., & Christiano, A. M. (2018) · Nature Communications · doi:10.1038/s41467-018-07579-y · Cited by 307
Self-citation3D bioprinting for skin tissue engineering: Current status and perspectives
Weng, T., Zhang, W., Xia, Y., Wu, P., Yang, M., Jin, R., Xia, S., Wang, J., You, C., Han, C., et al. (2021) · Journal of Tissue Engineering · doi:10.1177/20417314211028574 · Cited by 303
Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Sharma, A., Sances, S., Workman, M. J., & Svendsen, C. N. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.011 · Cited by 296
Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond
Liu, C., Oikonomopoulos, A., Sayed, N., & Wu, J. C. (2018) · Development · doi:10.1242/dev.156166 · Cited by 267
Metadata
- Authors
- Abaci, H. E., Guo, Z., Coffman, A., Gillette, B., Lee, W., Sia, S. K., & Christiano, A. M.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2016-06-22
- Volume
- 5
- Issue
- 14
- Pages
- 1800-1807
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2461744008
- Cited by
- 243
- References
- 6
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC‐Derived Endothelial Cells. https://app.cochat.ai/papers/10.1002/adhm.201500936
- The paper
- Abaci, H. E., Guo, Z., Coffman, A., Gillette, B., Lee, W., Sia, S. K., & Christiano, A. M. (2016). Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC‐Derived Endothelial Cells. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201500936
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
