The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Biomedical Use of Silk: Past, Present, Future
Open accessAbstract
Humans have long appreciated silk for its lustrous appeal and remarkable physical properties, yet as the mysteries of silk are unraveled, it becomes clear that this outstanding biopolymer is more than a high‐tech fiber. This progress report provides a critical but detailed insight into the biomedical use of silk. This journey begins with a historical perspective of silk and its uses, including the long‐standing desire to reverse engineer silk. Selected silk structure–function relationships are then examined to appreciate past and current silk challenges. From this, biocompatibility and biodegradation are reviewed with a specific focus of silk performance in humans. The current clinical uses of silk (e.g., sutures, surgical meshes, and fabrics) are discussed, as well as clinical trials (e.g., wound healing, tissue engineering) and emerging biomedical applications of silk across selected formats, such as silk solution, films, scaffolds, electrospun materials, hydrogels, and particles. The journey finishes with a look at the roadmap of next‐generation recombinant silks, especially the development pipeline of this new industry for clinical use.
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Cites
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High-strength silk protein scaffolds for bone repair
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Cited by
Silk biomaterials in wound healing and skin regeneration therapeutics: From bench to bedside
Chouhan, D., & Mandal, B. B. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.11.050 · Cited by 348
Hydrogel Preparation Methods and Biomaterials for Wound Dressing
Su, J., Li, J., Liang, J., Zhang, K., & Li, J. (2021) · Life · doi:10.3390/life11101016 · Cited by 300
Thermoplastic moulding of regenerated silk
Guo, C., Li, C., Vu, H. V., Hanna, P., Lechtig, A., Qiu, Y., Mu, X., Ling, S., Nazarian, A., Lin, S. J., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0560-8 · Cited by 268
Warinner, C., Korzow Richter, K., & Collins, M. J. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00703 · Cited by 178
Crosslinking strategies for silk fibroin hydrogels: promising biomedical materials
Farokhi, M., Aleemardani, M., Solouk, A., Mirzadeh, H., Teuschl, A. H., & Redl, H. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abb615 · Cited by 95
Metadata
- Authors
- Holland, C., Numata, K., Rnjak‐Kovacina, J., & Seib, F. P.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2018-09-20
- Volume
- 8
- Issue
- 1
- Pages
- e1800465-e1800465
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2893974579
- Cited by
- 815
- References
- 5
- FWCI
- 18.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
