The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Magnetically Actuated Degradable Microrobots for Actively Controlled Drug Release and Hyperthermia Therapy
Abstract
Microrobots facilitate targeted therapy due to their small size, minimal invasiveness, and precise wireless control. A degradable hyperthermia microrobot (DHM) with a 3D helical structure is developed, enabling actively controlled drug delivery, release, and hyperthermia therapy. The microrobot is made of poly(ethylene glycol) diacrylate (PEGDA) and pentaerythritol triacrylate (PETA) and contains magnetic Fe 3 O 4 nanoparticles (MNPs) and 5‐fluorouracil (5‐FU). Its locomotion is remotely and precisely controlled by a rotating magnetic field (RMF) generated by an electromagnetic actuation system. Drug‐free DHMs reduce the viability of cancer cells by elevating the temperature under an alternating magnetic field (AMF), a hyperthermic effect. 5‐FU is released from the proposed DHMs in normal‐, high‐burst‐, and constant‐release modes, controlled by the AMF. Finally, actively controlled drug release from the DHMs in normal‐ and high‐burst‐release mode results in a reduction in cell viability. The reduction in cell viability is of greater magnitude in high‐burst‐ than in normal‐release mode. In summary, biodegradable DHMs have potential for actively controlled drug release and hyperthermia therapy.
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Cites
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Polymeric systems for controlled drug release
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Bio-inspired magnetic swimming microrobots for biomedical applications
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Cited by
3D printing of functional microrobots
Li, J., & Pumera, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01062f · Cited by 303
Metadata
- Authors
- Park, J., Jin, C., Lee, S., Kim, J., & Choi, H.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2019-07-10
- Volume
- 8
- Issue
- 16
- Pages
- e1900213-e1900213
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2960639179
- Cited by
- 201
- References
- 9
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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