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Cited by 47Advancements in Transdermal Drug DeliveryWound Healing and TreatmentsElectrospun Nanofibers in Biomedical Applications

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Miniaturized Needle Array‐Mediated Drug Delivery Accelerates Wound Healing

Samandari, Mohamadmahdi, Aghabaglou, Fariba, Nuutila, Kristo, Derakhshandeh, Hossein, Zhang, Yuteng, Endo, Yori, Harris, Seth, Barnum, Lindsay, Kreikemeier‐Bower, Craig, Arab‐Tehrany, Elmira, Peppas, Nicholas A., Sinha, Indranil, Tamayol, Ali·2021·Advanced Healthcare Materials
DOI 10.1002/adhm.202001800
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Abstract

A major impediment preventing normal wound healing is insufficient vascularization, which causes hypoxia, poor metabolic support, and dysregulated physiological responses to injury. To combat this, the delivery of angiogenic factors, such as vascular endothelial growth factor (VEGF), has been shown to provide modest improvement in wound healing. Here, the importance of specialty delivery systems is explored in controlling wound bed drug distribution and consequently improving healing rate and quality. Two intradermal drug delivery systems, miniaturized needle arrays (MNAs) and liquid jet injectors (LJIs), are evaluated to compare effective VEGF delivery into the wound bed. The administered drug's penetration depth and distribution in tissue are significantly different between the two technologies. These systems' capability for efficient drug delivery is first confirmed in vitro and then assessed in vivo. While topical administration of VEGF shows limited effectiveness, intradermal delivery of VEGF in a diabetic murine model accelerates wound healing. To evaluate the translational feasibility of the strategy, the benefits of VEGF delivery using MNAs are assessed in a porcine model. The results demonstrate enhanced angiogenesis, reduced wound contraction, and increased regeneration. These findings show the importance of both therapeutics and delivery strategy in wound healing.

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Research works printed but not linked: 52

  1. 10.1038/nmat4294 · DOI
  2. 10.1016/j.jval.2017.07.007 · DOI
  3. 10.1016/j.tibtech.2018.07.007 · DOI
  4. 10.1002/adhm.201800396 · DOI
  5. 10.1016/j.addr.2018.04.008 · DOI
  6. 10.1038/nrm809 · DOI · Paper page
  7. 10.1016/S0140-6736(05)67700-8 · DOI
  8. 10.1089/wound.2017.0761 · DOI
  9. 10.1002/smll.201703509 · DOI
  10. 10.1089/wound.2012.0378 · DOI
  11. 10.1002/adfm.201905544 · DOI · Paper page
  12. 10.1111/exd.12929 · DOI
  13. 10.1111/wrr.12205 · DOI
  14. 10.1152/physrev.2003.83.3.835 · DOI · Paper page
  15. 10.1038/nmat4249 · DOI
  16. 10.1016/j.jss.2008.04.023 · DOI
  17. 10.1016/S0002-9440(10)63754-6 · DOI
  18. 10.1002/adfm.201702399 · DOI
  19. 10.1111/j.1524-475X.2008.00410.x · DOI · Paper page
  20. 10.1042/CS20040370 · DOI
  21. 10.1016/j.actbio.2013.04.019 · DOI
  22. 10.1172/JCI11317 · DOI · Paper page
  23. 10.1016/j.jacc.2005.06.008 · DOI
  24. 10.1016/j.actbio.2019.10.004 · DOI
  25. 10.1007/978-3-319-39168-7_4 · DOI
  26. Enoch S., 2003, Wounds, 15, 213
  27. 10.1080/17425247.2020.1819787 · DOI
  28. 10.1016/j.bioactmat.2020.02.004 · DOI
  29. 10.1016/j.addr.2018.09.010 · DOI
  30. 10.1089/wound.2014.0600 · DOI
  31. 10.1016/j.addr.2012.04.005 · DOI
  32. 10.1016/j.mser.2016.03.001 · DOI
  33. 10.1039/C8LC00098K · DOI
  34. 10.1007/s12079-016-0330-1 · DOI
  35. 10.1023/A:1020753329492 · DOI
  36. 10.1016/j.ijpharm.2008.08.032 · DOI
  37. 10.1038/sj.gt.3302767 · DOI
  38. 10.1111/srt.12235 · DOI
  39. 10.1002/jps.23835 · DOI
  40. 10.1002/adfm.201909197 · DOI
  41. 10.1039/D0LC00646G · DOI
  42. 10.1016/j.jconrel.2004.04.006 · DOI
  43. 10.1038/nrd2076 · DOI
  44. 10.1186/gb-2005-6-2-209 · DOI
  45. 10.1016/0026-2862(77)90141-8 · DOI
  46. 10.1016/j.colsurfb.2014.09.013 · DOI
  47. 10.1016/j.jacc.2010.01.070 · DOI
  48. 10.1186/s12885-018-4180-5 · DOI
  49. 10.1126/scitranslmed.3009337 · DOI · Paper page
  50. 10.1002/path.1427 · DOI · Paper page
  51. 10.1016/j.jdermsci.2017.12.009 · DOI · Paper page
  52. 10.1016/j.burns.2008.01.010 · DOI

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Metadata

Authors
Samandari, M., Aghabaglou, F., Nuutila, K., Derakhshandeh, H., Zhang, Y., Endo, Y., Harris, S., Barnum, L., Kreikemeier‐Bower, C., Arab‐Tehrany, E., Peppas, N. A., Sinha, I., & Tamayol, A.
Affiliations
  • University of Connecticut (US)
  • Johns Hopkins University (US)
  • Brigham and Women's Hospital (US)
  • University of Nebraska–Lincoln (US)
  • Laboratoire d'Ingénierie des Biomolécules (FR)
  • The University of Texas at Austin (US)
Corresponding author
  • Peppas, Nicholas A.
  • Sinha, Indranil
  • Tamayol, Ali
ORCID
Venue
Advanced Healthcare Materials
Publisher
Wiley
Published
2021-02-15
Volume
10
Issue
8
Pages
e2001800-e2001800
ISSN
  • 2192-2640 (ISSN-L)
  • 2192-2659
DOI
10.1002/adhm.202001800
OpenAlex
W3132095342
Cited by
47
References
3
Citations by year
2026: 3 · 2025: 10 · 2024: 5 · 2023: 14 · 2022: 10 · 2021: 5
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Healthcare Materials (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
National Institutes of Health (R01‐GM126831, R01‐AR073822, R01‐EB022025, K76AG059996)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
wound healing, vascular endothelial growth factor, angiogenesis, intradermal drug delivery, diabetic wound healing, porcine model, wound contraction, tissue regeneration
MeSH terms
Animals, Pharmaceutical Preparations, Swine, Wound Healing, Neovascularization, Physiologic, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiogenesis Inducing Agents, Mice

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