A Wirelessly Controlled Smart Bandage with 3D‐Printed Miniaturized Needle Arrays
Open accessAbstract
Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic wounds, their clinical translation is limited. Given the range of disruptive processes necessary for wound healing, different pharmacological agents are needed at different stages of tissue regeneration. This requires the development of wearable devices that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Here, for the first time, a programmable platform is engineered that is capable of actively delivering a variety of drugs with independent temporal profiles through miniaturized needles into deeper layers of the wound bed. The delivery of vascular endothelial growth factor (VEGF) through the miniaturized needle arrays demonstrates that, in addition to the selection of suitable therapeutics, the delivery method and their spatial distribution within the wound bed is equally important. Administration of VEGF to chronic dermal wounds of diabetic mice using the programmable platform shows a significant increase in wound closure, re‐epithelialization, angiogenesis, and hair growth when compared to standard topical delivery of therapeutics.
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Microneedles are emerging minimally invasive drug delivery tools.
“One of the emerging minimally invasive drug delivery tools is microneedles [262,263,264].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [263]
Administering VEGF to chronic dermal wounds in diabetic mice using the programmable platform resulted in notable enhancements in wound closure, re-epithelialization, angiogenesis, and hair growth compared to conventional topical application.
“In the case of administering VEGF to chronic dermal wounds in diabetic mice using the programmable platform, notable enhancements are observed in wound closure, re-epithelialization, angiogenesis, and hair growth compared to the conventional method of topically applying therapeutics.”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Derakhshandeh et al. 2020
A wearable and programmable bandage incorporating polymeric miniaturized needle arrays (MNAs) facilitates targeted delivery of essential pharmacological agents and growth factors into deeper layers of a wound.
“For instance, A. Tamayol’s group developed a wearable and programmable bandage, which incorporates polymeric miniaturized needle arrays (MNAs) to facilitate the targeted delivery of essential pharmacological agents and growth factors into the deeper layers of a wound (Fig. 5a) (Derakhshandeh et al. 2020).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Derakhshandeh et al. 2020
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1 retracted
Kumar, P. T. S., Lakshmanan, V., Anilkumar, T. V., et al. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am300292v · Cited by 755 · see citing works
RetractedFactors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792 · see citing works
Human skin wounds: A major and snowballing threat to public health and the economy
Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00543.x · Cited by 2,965 · see citing works
Challenges in the Treatment of Chronic Wounds
Frykberg, R. G., & Banks, J. (2015) · Advances in Wound Care · doi:10.1089/wound.2015.0635 · Cited by 2,703 · see citing works
Antibiotics and Bacterial Resistance in the 21st Century
Fair, R. J., & Tor, Y. (2014) · Perspectives in Medicinal Chemistry · doi:10.4137/pmc.s14459 · Cited by 1,979 · see citing works
Characterization of Polydimethylsiloxane (PDMS) Properties for Biomedical Micro/Nanosystems
Mata, Á., Fleischman, A. J., & Roy, S. (2005) · Biomedical Microdevices · doi:10.1007/s10544-005-6070-2 · Cited by 1,321 · see citing works
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307 · see citing works
Advanced Therapeutic Dressings for Effective Wound Healing—A Review
Boateng, J. S., & Catanzano, O. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24610 · Cited by 957 · see citing works
Drug delivery systems and materials for wound healing applications
Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., et al. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.008 · Cited by 864 · see citing works
Self-citationAcute and Impaired Wound Healing
Demidova‐Rice, T. N., Hamblin, M. R., & Herman, I. M. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000416006.55218.d0 · Cited by 726 · see citing works
Control of hair growth and follicle size by VEGF-mediated angiogenesis
Yano, K., Brown, L. F., & Detmar, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11317 · Cited by 710 · see citing works
Microneedle technologies for (trans)dermal drug and vaccine delivery
van der Maaden, K., Jiskoot, W., & Bouwstra, J. A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.042 · Cited by 657 · see citing works
Chronic Wound Pathogenesis and Current Treatment Strategies: A Unifying Hypothesis
Mustoe, T. A., O??Shaughnessy, K., & Kloeters, O. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225431.63010.1b · Cited by 653 · see citing works
Wound management for the 21st century: combining effectiveness and efficiency
Lindholm, C., & Searle, R. J. (2016) · International Wound Journal · doi:10.1111/iwj.12623 · Cited by 553 · see citing works
Choi, J. S., Leong, K. W., & Yoo, H. S. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.012 · Cited by 516 · see citing works
Smart Bandage for Monitoring and Treatment of Chronic Wounds
Mostafalu, P., Tamayol, A., Rahimi, R., Ochoa, M., Khalilpour, A., Kiaee, G., Yazdi, I. K., Bagherifard, S., Dokmeci, M. R., Ziaie, B., et al. (2018) · Small · doi:10.1002/smll.201703509 · Cited by 482 · see citing works
Self-citationSkin thickness of Korean adults
Lee, Y., & Hwang, K. (2002) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-002-0034-5 · Cited by 475 · see citing works
Biofilms and Wounds: An Overview of the Evidence
Percival, S. L., McCarty, S. M., & Lipsky, B. A. (2014) · Advances in Wound Care · doi:10.1089/wound.2014.0557 · Cited by 424 · see citing works
Advances in surgical applications of growth factors for wound healing
Yamakawa, S., & Hayashida, K. (2019) · Burns & Trauma · doi:10.1186/s41038-019-0148-1 · Cited by 347 · see citing works
Smart Bandages: The Future of Wound Care
Derakhshandeh, H., Kashaf, S. S., Aghabaglou, F., Ghanavati, I., & Tamayol, A. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.07.007 · Cited by 320 · see citing works
Self-citationFlexible pH‐Sensing Hydrogel Fibers for Epidermal Applications
Tamayol, A., Akbari, M., Zilberman, Y., Comotto, M., Lesha, E., Serex, L., Bagherifard, S., Chen, Y., Fu, G., Ameri, S. K., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500553 · Cited by 262 · see citing works
Self-citationA Textile Dressing for Temporal and Dosage Controlled Drug Delivery
Mostafalu, P., Kiaee, G., Giatsidis, G., Khalilpour, A., Nabavinia, M., Dokmeci, M. R., Sonkusale, S., Orgill, D. P., Tamayol, A., & Khademhosseini, A. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201702399 · Cited by 256 · see citing works
Self-citationRanderia, P. S., Seeger, M. A., Wang, X.-Q., Wilson, H. M., Shipp, D. M., Mirkin, C. A., & Paller, A. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505951112 · Cited by 224 · see citing works
Fife, C. E., & Carter, M. J. (2012) · PubMed · Cited by 222 · see citing works
Werdin, F., Tenenhaus, M., & Rennekampff, H. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61793-6 · Cited by 185 · see citing works
Ahmad, J. (2015) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2015.04.002 · Cited by 156 · see citing works
Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery
Bagherifard, S., Tamayol, A., Mostafalu, P., Akbari, M., Comotto, M., Annabi, N., Ghaderi, M., Sonkusale, S., Dokmeci, M. R., & Khademhosseini, A. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500357 · Cited by 151 · see citing works
Self-citationTamayol, A., Hassani Najafabadi, A., Mostafalu, P., Yetisen, A. K., Commotto, M., Aldhahri, M., Abdel-wahab, M. S., Najafabadi, Z. I., Latifi, S., Akbari, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04749-8 · Cited by 115 · see citing works
Self-citationA pH‐Mediated Electronic Wound Dressing for Controlled Drug Delivery
Kiaee, G., Mostafalu, P., Samandari, M., & Sonkusale, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800396 · Cited by 105 · see citing works
Self-citationZhang, D., Das, D. B., & Rielly, C. D. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23835 · Cited by 90 · see citing works
Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells
Guo, J., Dardik, A., Fang, K., Huang, R., & Gu, Y. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0683-2 · Cited by 63 · see citing works
Biomaterials: A potential pathway to healing chronic wounds?
Pop, M. A., & Almquist, B. D. (2017) · Experimental Dermatology · doi:10.1111/exd.13290 · Cited by 51 · see citing works
3D‐Printed Sugar‐Based Stents Facilitating Vascular Anastomosis
Farzin, A., Miri, A. K., Sharifi, F., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800702 · Cited by 45 · see citing works
Rimington, R. P., Capel, A. J., Player, D. J., Bibb, R., Christie, S. D. R., & Lewis, M. P. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800113 · Cited by 41 · see citing works
Kunugiza, Y., Tomita, N., Taniyama, Y., et al. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302767 · Cited by 33 · see citing works
Rinkel, W. D., Rizopoulos, D., Aziz, M. H., van Neck, J. W., Cabezas, M. C., & Coert, J. H. (2018) · Muscle & Nerve · doi:10.1002/mus.26192 · Cited by 19 · see citing works
Smart Bandages: Smart Bandage for Monitoring and Treatment of Chronic Wounds (Small 33/2018)
Mostafalu, P., Tamayol, A., Rahimi, R., et al. (2018) · Small · doi:10.1002/smll.201870150 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [5]a) Demidova-Rice TN, Hamblin MR, Herman IM, Adv. Skin Wound Care 2012, 25, 304; 22713781 PMC3428147 b) Percival, McCarty SM, Lipsky B, Adv. Wound Care 2015, 4, 373. PMC4486148 26155379
- [13]Punjiya M, Mostafalu P, Sonkusale S, presented at 2017 IEEE 60th International Midwest Symposium on Circuits and Systems (MWSCAS), Medford, MA, August 2017.
Cited by
Sorted by citations
Advances in healthcare wearable devices
Iqbal, S. M. A., Mahgoub, I., Du, E., Leavitt, M. A., & Asghar, W. (2021) · npj Flexible Electronics · doi:10.1038/s41528-021-00107-x · Cited by 714 · see citing works
Alzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works
Self-citationWang, C., He, T., Zhou, H., Zhang, Z., & Lee, C. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00118-1 · Cited by 295 · see citing works
Wearable and implantable devices for drug delivery: Applications and challenges
Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121435 · Cited by 179 · see citing works
Recent Advances in Intelligent Wearable Medical Devices Integrating Biosensing and Drug Delivery
Tan, M., Xu, Y., Gao, Z., Yuan, T., Liu, Q., Yang, R., Zhang, B., & Peng, L. (2022) · Advanced Materials · doi:10.1002/adma.202108491 · Cited by 187 · see citing works
Self-citation
- Authors
- Derakhshandeh, H., Aghabaglou, F., McCarthy, A., Mostafavi, A., Wiseman, C., Bonick, Z., Ghanavati, I., Harris, S., Kreikemeier‐Bower, C., Moosavi Basri, S. M., Rosenbohm, J., Yang, R., Mostafalu, P., Orgill, D., & Tamayol, A.
- Affiliations
- University of Nebraska–Lincoln (US)
- Department of Biomedical Engineering American University of Sharjah Sharjah 26666 United Arab Emirates
- Brigham and Women's Hospital (US)
- Corresponding author
- Tamayol, Ali
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2020-02-13
- Volume
- 30
- Issue
- 13
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- PMC
- PMC8336080
- OpenAlex
- W3005782970
- Cited by
- 188
- References
- 37
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 41 · 2023: 37 · 2022: 31 · 2021: 26 · 2020: 9
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Advanced Functional Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Funders
- National Institutes of Health (GM126831, AR073822, P20GM113126)
- National Science Foundation (1826135)
- University of Nebraska-Lincoln
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- smart bandages, wireless drug delivery, chronic wounds, diabetic wounds, VEGF delivery, wound bed, re-epithelialization, angiogenesis, hair growth, minimally invasive drug delivery
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