Cited by 235Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsAdvanced Drug Delivery Systems

Polymeric micelles: authoritative aspects for drug delivery

Kulthe, Sushant S., Choudhari, Yogesh M., Inamdar, Nazma N., Mourya, Vishnukant·2012·Designed Monomers and Polymers

Abstract

The generation of supramolecular architectures with well-defined structures and functionalities is recently garnering attraction. Self-assemblage of amphiphilic polymers leads to the formation of polymeric micelles that demonstrate unique set of characteristics such as excellent biocompatibility, low toxicity, enhanced blood circulation time, and solubilization of poorly water-soluble drugs. In this article, we provide an up-to-date review on important aspects of polymeric micelles. Critical factors for solubilization of hydrophobic drugs in the micellar core are discussed. Polymeric micelles can be used as 'smart' drug carriers for targeting certain areas of the body. Here, we have especially emphasized on the recent developments in the targetability of certain tissues such as cancerous tissues using polymeric micelles. Different stimuli exploited for creating stimuli-sensitive micelles are discussed comprehensively. Application of polymeric micelles in the photodynamic therapy is also meticulously described.

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Crossref · 10.1080/1385772x.2012.688328

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430 of 430 references verified0 citation errors · 0 not checkable

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  • The hydrophilic part of micelles is usually composed of PEG, but other polymers are also used; the hydrophobic segment can be made up of poly(propylene oxide) or polyesters like poly(ε-caprolactone) or polymers and co-polymers of glycolic and lactic acids.

    “The hydrophilic part is usually composed of PEG (polyethylenglycole), but other polymers are also used such as poly(vinyl pyrrolidone), poly (acryloylmorpholine), or poly(trimethylene carbonate); the hydrophobic segment can be made up of poly(propylene oxide), or polyesters like poly(ε-caprolactone) or polymers and co-polymers of glycolic and lactic acids [36].”
  • The most investigated administration route for micelles is intravenous injection/infusion, mainly for chemotherapy, but improved drug bioavailability has also been reported following oral and topical administration.

    “The most investigated administration route for micelles is the intravenous (i.v.) injection/infusion (mainly exploited for chemotherapy) [18,[47][48][49], but very interesting results in terms of improved drug bioavailability have also been reported following oral [31,50] and topical (ocular, nasal, buccal) [26,36,51,52] administration.”

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Authors
Kulthe, S. S., Choudhari, Y. M., Inamdar, N. N., & Mourya, V.
Affiliations
a Government College of Pharmacy , Aurangabad , 431005 , Maharashtra , India
Venue
Designed Monomers and Polymers
Published
2012-07-02
Volume
15
Issue
5
Pages
465-521
ISSN
  • 1385-772X (ISSN-L)
  • 1568-5551
OpenAlex
W2070517405
Cited by
235
References
431
Citations by year
2026: 16 · 2025: 17 · 2024: 23 · 2023: 28 · 2022: 44 · 2021: 33 · 2020: 25 · 2019: 11 · 2018: 11 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 12
FWCI
2.85
Type
journal article
Language
en
Open access
closed
Locations
Designed Monomers & Polymers (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric micelles, drug delivery, amphiphilic polymers, self-assembly, hydrophobic drug solubilization, targeted drug delivery, tumor targeting, stimuli-responsive micelles, photodynamic therapy, biocompatibility

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