Self-assembled micellar nanoparticles of a novel star copolymer for thermo and pH dual-responsive drug release
Abstract
An amphiphilic star block copolymer comprised of a hydrophobic PMMA block and a hydrophilic tri-arm poly(NIPAAm-co-DMAEMA) block was synthesized by copolymerization of NIPAAm and DMAEMA, with Ce(4+) ions and tris(hydroxymethyl)methylamine as a redox initiatory system. The star copolymer undergoes self-assembly to the micellar nanoparticles with a core-shell structure and the thermo/pH dual-response, originated from the thermo-sensitivity of PNIPAAm and the pH-sensitivity of PDMAEMA. A fluorescence probe study showed the pH-dependent low CMCs (7.5 to 11.2 mg/L) of the micelles, confirming the formation of stable micelles. Morphological investigations showed that the blank and drug-loaded micelles both had spherical and uniform shapes. The sizes of the blank and drug-loaded nanoparticles were between 80 and 120 nm, depending on the given pH. The LCSTs of the star copolymer were determined to be 32 degrees C, 36.6 degrees C and 39.5 degrees C, corresponding to pH 5, pH 7.4 and pH 9, respectively, demonstrating a pH-dependent thermo-response. As a drug delivery, the micellar nanoparticles showed the dual-responsive release profiles in vitro, which were confirmed by the drug release studies. The obtained results showed the thermo-triggered accelerated release at pH 7.4, and the pH-triggered accelerated release at 37 degrees C, indicating the micelles nanoparticles would be a promising site-specific drug delivery for enhancing the accumulation of drug in targeting pathological areas.
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Novel copolymer micelle-based nanocarriers showed temperature and pH responsive release performance of methotrexate (MTX) drug.
“Nanomicelles formed showed temperature and pH responsive release performance of methotrexate (MTX) drug.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [115]
The developed nanocarriers would be a promising site-specific drug delivery system which could improve the drug accumulation in pathological sites.
“The developed nanocarriers would be a promising site-specific drug delivery system which could improve the drug accumulation in pathological sites.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [115]
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Background
- Authors
- Liu, Y., Cao, X., Luo, M., Le, Z., & Xu, W.
- Corresponding author
- Liu, Yunhai
- Venue
- Journal of Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 329
- Issue
- 2
- Pages
- 244-252
- ISSN
- 0021-9797 (ISSN-L)
- OpenAlex
- W2035045639
- Cited by
- 96
- References
- 41
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 14 · 2012: 7
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Colloid and Interface Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- star block copolymers, micellar nanoparticles, pH-responsive drug release, dual-responsive drug delivery, poly(N-isopropylacrylamide), PDMAEMA, PMMA, self-assembly, lower critical solution temperature, critical micelle concentration, fluorescent probes, local drug delivery, core-shell structure
- MeSH terms
- Delayed-Action Preparations, Hydrogen-Ion Concentration, Micelles, Polymers, Temperature, Nanoparticles
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