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Cited by 278

The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.

Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems

Bauhuber, Sonja, Hozsa, Constantin, Breunig, Miriam, Göpferich, Achim·2009·Advanced Materials
DOI 10.1002/adma.200802453
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Abstract

Nucleic acids are not only expected to assume a pivotal position as “drugs” in the treatment of genetic and acquired diseases, but could also act as molecular cues to control the microenvironment during tissue regeneration. Despite this promise, the efficient delivery of nucleic acids to their side of action is still the major hurdle. One among many prerequisites for a successful carrier system for nucleic acids is high stability in the extracellular environment, accompanied by an efficient release of the cargo in the intracellular compartment. A promising strategy to create such an interactive delivery system is to exploit the redox gradient between the extra‐ and intracellular compartments. In this review, emphasis is placed on the biological rationale for the synthesis of redox sensitive, disulfide‐based carrier systems, as well as the extra‐ and intracellular processing of macromolecules containing disulfide bonds. Moreover, the basic synthetic approaches for introducing disulfide bonds into carrier molecules, together with examples that demonstrate the benefit of disulfides at the individual stages of nucleic acid delivery, will be presented.

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Metadata

Authors
Bauhuber, S., Hozsa, C., Breunig, M., & Göpferich, A.
Venue
Advanced Materials
Publisher
Wiley
Published
2009-08-28
Volume
21
Issue
32-33
Pages
3286-3306
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.200802453
OpenAlex
W2075302245
Cited by
278
References
178
FWCI
8.16
Type
journal article
Language
en
Open access
closed

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