The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles
Open accessAbstract
The use of nanoparticles in medicine (nanomedicine) has recently become an intensely studied field. Nanoparticles carrying drugs and imaging agents have already reached the clinic, but they are essentially passive delivery vehicles, not what are referred to as “smart” nanoparticles. An important function to add to make nanoparticles smarter is active homing to the target tissue. It makes nanoparticles accumulate in the target tissue at higher concentrations than would be the case without this feature, increasing therapeutic efficacy and reducing side effects. This review discusses the recent developments in the nanoparticle targeting field with emphasis on peptides that home to vascular “zip codes” in target tissues and provide a tissue‐ and cell‐penetrating function.
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Cites
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Self-citation
Cited by
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“Further, these peptides may not only play a role in homing but in tumor-penetration, as is the case with iRGD, because they allow for the exit from blood vessels and can activate a tissue-specific transport pathway [105], which is a big advantage in treating resistant tumors.”
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Self-citationEngineered nanomedicines with enhanced tumor penetration
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Metadata
- Authors
- Ruoslahti, E.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2012-05-02
- Volume
- 24
- Issue
- 28
- Pages
- 3747-3756
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2082575848
- Cited by
- 419
- References
- 88
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- green
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