Cited by 299Nanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems

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Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

Xiong, Meng‐Hua, Li, Ya‐Juan, Bao, Yan, Yang, Xian‐Zhu, Hu, Bing, Wang, Jun·2012·Advanced Materials

DOI 10.1002/adma.201202847

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Abstract

Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.

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Authors: Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J.
Affiliations: University of Science and Technology of China (CN)
Corresponding author: Hu, Bing
Wang, Jun
ORCID: Bao, Yan
Hu, Bing
Wang, Jun
Venue: Advanced Materials
Publisher: Wiley
Published: 2012-09-10
Volume: 24
Issue: 46
Pages: 6175-6180
ISSN: 0935-9648 (ISSN-L)
1521-4095
DOI: 10.1002/adma.201202847
OpenAlex: W2135595096
Cited by: 299
References: 49
Citations by year: 2026: 6 · 2025: 15 · 2024: 20 · 2023: 22 · 2022: 38 · 2021: 41 · 2020: 31 · 2019: 25 · 2018: 23 · 2017: 25 · 2016: 17 · 2015: 11 · 2014: 14 · 2013: 10
FWCI: 4.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Materials (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: targeted antibiotic delivery, enzyme-responsive drug release, polyphosphoesters, macrophage targeting, bacterial infection, bacterial growth inhibition
MeSH terms: Nanogels, Animals, Anti-Bacterial Agents, Bacteria, Cell Line, Drug Carriers, Embryo, Nonmammalian, Macrophages, Phagocytosis, Phospholipases, Polyethylene Glycols, Polyethyleneimine, Vancomycin, Zebrafish, Microscopy, Confocal, Mice, Methicillin-Resistant Staphylococcus aureus

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Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

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