Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies
Abstract
Advances in nanomedicine, including early cancer detection, targeted drug delivery, and personalized approaches to cancer treatment are on the rise. For example, targeted drug delivery systems can improve intracellular delivery because of their multifunctionality. Novel endogenous-based and exogenous-based stimulus-responsive drug delivery systems have been proposed to prevent the cancer progression with proper drug delivery. To control effective dose loading and sustained release, targeted permeability and individual variability can now be described in more-complex ways, such as by combining internal and external stimuli. Despite these advances in release control, certain challenges remain and are identified in this research, which emphasizes the control of drug release and applications of nanoparticle-based drug delivery systems. Using a multiscale and multidisciplinary approach, this study investigates and analyzes drug delivery and release strategies in the nanoparticle-based treatment of cancer, both mathematically and clinically.
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Cancer cells primarily use glucose, fatty acids, and amino acids to meet their biosynthetic needs.
“In other words, cancer cells primarily use glucose, fatty acids, and amino acids to meet their biosynthetic needs [49–52].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [51]
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- Authors
- Moradi Kashkooli, F., Soltani, M., & Souri, M.
- Affiliations
- University of Waterloo (CA)
- K. N. Toosi University of Technology (IR)
- Corresponding author
- Soltani, M.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 327
- Pages
- 316-349
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W3048944217
- Cited by
- 514
- References
- 11
- Citations by year
- 2026: 34 · 2025: 126 · 2024: 139 · 2023: 89 · 2022: 70 · 2021: 50 · 2020: 6
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- controlled drug release, nanoparticle drug delivery, targeted drug delivery, cancer nanomedicine, stimuli-responsive drug delivery, sustained drug release, multiscale modeling, precision oncology
- MeSH terms
- Antineoplastic Agents, Drug Carriers, Humans, Neoplasms, Drug Delivery Systems, Nanomedicine, Nanoparticles
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