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Cited by 602Luminescence and Fluorescent MaterialsLuminescence Properties of Advanced MaterialsQuantum Dots Synthesis And Properties

Ultralong Phosphorescence of Water‐Soluble Organic Nanoparticles for In Vivo Afterglow Imaging

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Zhen, Xu, Tao, Ye, An, Zhongfu, Chen, Peng, Xu, Chenjie, Chen, Runfeng, Huang, Wei, Pu, Kanyi·2017·Advanced Materials
DOI 10.1002/adma.201606665
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Abstract

Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rare and limited to inorganic nanoparticles. This study reports the design principle, synthesis, and proof‐of‐concept application of organic semiconducting nanoparticles (OSNs) with ultralong phosphorescence for in vivo afterglow imaging. The design principle leverages the formation of aggregates through a top‐down nanoparticle formulation to greatly stabilize the triplet excited states of a phosphorescent molecule. This prolongs the particle luminesce to the timescale that can be detected by the commercial whole‐animal imaging system after removal of external light source. Such ultralong phosphorescent of OSNs is inert to oxygen and can be repeatedly activated, permitting imaging of lymph nodes in living mice with a high signal‐to‐noise ratio. This study not only introduces the first category of water‐soluble ultralong phosphorescence organic nanoparticles but also reveals a universal design principle to prolong the lifetime of phosphorescent molecules to the level that can be effective for molecular imaging.

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Authors
Zhen, X., Tao, Y., An, Z., Chen, P., Xu, C., Chen, R., Huang, W., & Pu, K.
Affiliations
  • School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637457, Singapore
  • Nanjing University of Posts and Telecommunications (CN)
  • Nanjing Tech University (CN)
  • Nanyang Technological University (SG)
Corresponding author
  • Chen, Runfeng
  • Huang, Wei
  • Pu, Kanyi
ORCID
Venue
Advanced Materials
Publisher
Wiley
Published
2017-06-28
Volume
29
Issue
33
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.201606665
OpenAlex
W2730550298
Cited by
602
References
46
Citations by year
2026: 45 · 2025: 67 · 2024: 83 · 2023: 93 · 2022: 70 · 2021: 78 · 2020: 59 · 2019: 63 · 2018: 40 · 2017: 3
FWCI
19.03
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
  • DR-NTU (Nanyang Technological University) (submittedVersion)
Funders
  • Nanyang Technological University (NTU‐SUG: M4081627.120)
  • Ministry of Education - Singapore
  • National Natural Science Foundation of China (21674049, 21304049, 61136003, 2015CB932200)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
Keywords
ultralong phosphorescence, persistent luminescence, afterglow imaging, water-soluble nanoparticles, nanoparticle aggregation, lymph node imaging, in vivo molecular imaging

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