Real‐Time and High‐Resolution Bioimaging with Bright Aggregation‐Induced Emission Dots in Short‐Wave Infrared Region
Abstract
Fluorescence imaging in the spectral region beyond the conventional near‐infrared biological window (700–900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short‐wave infrared (SWIR; 900–1700 nm) imaging modality in the past decade, long‐wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation‐induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region. The long‐wavelength emission of AIE dots with certain brightness facilitates resolving brain capillaries with high spatial resolution (≈3 µm) and deep penetration (800 µm). Owning to the deep penetration depth and real‐time imaging capability, in vivo SWIR microscopic angiography exhibits superior resolution in monitoring blood–brain barrier damage in mouse brain, and visualizing enhanced permeability and retention effect in tumor sites. Furthermore, the AIE dots show good biocompatibility, and no noticeable abnormalities, inflammations or lesions are observed in the main organs of the mice. This work will inspire new insights on development of advanced SWIR techniques for biomedical imaging.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The electron affinity of 6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoline and its analogs is slightly weaker than that of BBTD, but they possess excellent chemical stability and enhanced solubility, demonstrating significant potential for NIR-II fluorophores.
“The electron affinity of 6,7-diphenyl-[1,2,5]thiadiazolo[3,4-g]quinoline and its analogs is slightly weaker than that of BBTD, but they possess excellent chemical stability and enhanced solubility, demonstrating significant potential for the development of NIR-II fluorophores152.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [152]
Cites
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270 · see citing works
Self-citationPhotophysics of aromatic molecules
Sharnoff, M. (1971) · Journal of Luminescence · doi:10.1016/0022-2313(71)90011-1 · Cited by 4,509 · see citing works
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,013 · see citing works
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848 · see citing works
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,704 · see citing works
Bioprobes Based on AIE Fluorogens
Ding, D., Li, K., Liu, B., & Tang, B. Z. (2013) · Accounts of Chemical Research · doi:10.1021/ar3003464 · Cited by 1,821 · see citing works
Self-citationA small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,364 · see citing works
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287 · see citing works
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice
Pu, K., Shuhendler, A. J., Jokerst, J. V., Mei, J., Gambhir, S. S., Bao, Z., & Rao, J. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2013.302 · Cited by 1,185 · see citing works
Maeda, H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.01.002 · Cited by 1,179 · see citing works
Direct detection of early-stage cancers using circulating tumor DNA
Phallen, J. A., Sausen, M., Adleff, V., Leal, A., Hruban, C., White, J. R., Anagnostou, V., Fiksel, J., Cristiano, S., Papp, E., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan2415 · Cited by 1,129 · see citing works
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995 · see citing works
Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging
Li, K., & Liu, B. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00014e · Cited by 989 · see citing works
Molecular afterglow imaging with bright, biodegradable polymer nanoparticles
Miao, Q., Xie, C., Xu, Z. J., Lyu, Y., Duan, H., Liu, X., Jokerst, J. V., & Pu, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3987 · Cited by 979 · see citing works
Near‐Infrared Photoluminescent Polymer–Carbon Nanodots with Two‐Photon Fluorescence
Lu, S., Sui, L., Liu, J., Zhu, S., Chen, A., Jin, M., & Yang, B. J. (2017) · Advanced Materials · doi:10.1002/adma.201603443 · Cited by 842 · see citing works
Hemmer, E., Benayas, A., Légaré, F., & Vetrone, F. (2016) · Nanoscale Horizons · doi:10.1039/c5nh00073d · Cited by 732 · see citing works
Next-generation in vivo optical imaging with short-wave infrared quantum dots
Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686 · see citing works
Jia, Y., Bailey, S. T., Hwang, T. S., McClintic, S. M., Gao, S. S., Pennesi, M. E., Flaxel, C. J., Lauer, A. K., Wilson, D. J., Joachim Hornegger, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500185112 · Cited by 668 · see citing works
Ultralong Phosphorescence of Water‐Soluble Organic Nanoparticles for In Vivo Afterglow Imaging
Zhen, X., Tao, Y., An, Z., Chen, P., Xu, C., Chen, R., Huang, W., & Pu, K. (2017) · Advanced Materials · doi:10.1002/adma.201606665 · Cited by 602 · see citing works
AIE Luminogens for Bioimaging and Theranostics: From Organelles to Animals
Qian, J., & Tang, B. Z. (2017) · Chem · doi:10.1016/j.chempr.2017.05.010 · Cited by 576 · see citing works
Self-citationRao, L., Bu, L., Xu, J., Cai, B., Yu, G., Yu, X., He, Z., Huang, Q., Li, A., Guo, S., et al. (2015) · Small · doi:10.1002/smll.201502388 · Cited by 518 · see citing works
Self-citationLiang, C., Diao, S., Wang, C., Gong, H., Liu, T., Hong, G., Shi, X., Dai, H., & Liu, Z. (2014) · Advanced Materials · doi:10.1002/adma.201401825 · Cited by 502 · see citing works
Meta-analysis of cellular toxicity for cadmium-containing quantum dots
Oh, E., Liu, R., Nel, A., Gemill, K. B., Bilal, M., Cohen, Y., & Medintz, I. L. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.338 · Cited by 502 · see citing works
Gu, Z., Yan, L., Tian, G., Li, S., Chai, Z., & Zhao, Y. (2013) · Advanced Materials · doi:10.1002/adma.201301197 · Cited by 492 · see citing works
Statins: new American guidelines for prevention of cardiovascular disease
Ridker, P. M., & Cook, N. R. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62388-0 · Cited by 477 · see citing works
Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window
Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H., Antaris, A., Ma, R., et al. (2017) · Advanced Materials · doi:10.1002/adma.201605497 · Cited by 467 · see citing works
Wu, W., Mao, D., Hu, F., Xu, S., Chen, C., Zhang, C., Cheng, X., Yuan, Y., Ding, D., Kong, D., et al. (2017) · Advanced Materials · doi:10.1002/adma.201700548 · Cited by 463 · see citing works
Aqueous Based Semiconductor Nanocrystals
Jing, L., Kershaw, S. V., Li, Y., Huang, X., Li, Y., Rogach, A. L., & Gao, M. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00041 · Cited by 454 · see citing works
Ai, X., Ho, C. J. H., Aw, J., Attia, A. B. E., Mu, J., Wang, Y., Wang, X., Wang, Y., Liu, X., Chen, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10432 · Cited by 433 · see citing works
Shao, W., Chen, G., Kuzmin, A., Kutscher, H. L., Pliss, A., Ohulchanskyy, T. Y., & Prasad, P. N. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08973 · Cited by 386 · see citing works
Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer
Sun, Y., Qu, C., Chen, H., He, M., Tang, C. C., Shou, K., Hong, S., Yang, M., Jiang, Y., Ding, B., et al. (2016) · Chemical Science · doi:10.1039/c6sc01561a · Cited by 294 · see citing works
Cheng, L., He, W., Gong, H., Wang, C., Chen, Q., Cheng, Z., & Liu, Z. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201301045 · Cited by 278 · see citing works
Loud, P. A., Katz, D. S., Bruce, D., Klippenstein, D. L., & GROSSMAN, Z. D. (2001) · Radiology · doi:10.1148/radiology.219.2.r01ma26498 · Cited by 262 · see citing works
Lv, G., Guo, W., Zhang, W., Zhang, T., Li, S., Chen, S., Eltahan, A. S., Wang, D., Wang, Y., Zhang, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b05419 · Cited by 256 · see citing works
Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy
Barretto, R. P. J., Ko, T. H., Jung, J. C., Wang, T. J., Capps, G., Waters, A. C., Ziv, Y., Attardo, A., Recht, L. D., & Schnitzer, M. J. (2011) · Nature Medicine · doi:10.1038/nm.2292 · Cited by 253 · see citing works
Multiscale Humidity Visualization by Environmentally Sensitive Fluorescent Molecular Rotors
Cheng, Y., Wang, J., Qiu, Z., Zheng, X., Leung, N. L. C., Lam, J. W. Y., & Tang, B. Z. (2017) · Advanced Materials · doi:10.1002/adma.201703900 · Cited by 248 · see citing works
Self-citationQi, J., Fang, Y., Kwok, R. T. K., Zhang, X., Hu, X., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b03062 · Cited by 246 · see citing works
Self-citationClinical imaging in regenerative medicine
Naumova, A. V., Modo, M., Moore, A. V., Murry, C. E., & Frank, J. A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2993 · Cited by 244 · see citing works
Ma, Y., Tong, S., Bao, G., Gao, C., & Dai, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.007 · Cited by 241 · see citing works
Du, X., Qi, J., Zhang, Z., Ma, D., & Wang, Z. Y. (2012) · Chemistry of Materials · doi:10.1021/cm3008733 · Cited by 238 · see citing works
Self-citationQin, W., Li, K., Feng, G., Li, M., Yang, Z., Liu, B., & Tang, B. Z. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201302114 · Cited by 227 · see citing works
Self-citationNear-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
He, X., Gao, J., Gambhir, S. S., & Cheng, Z. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.08.006 · Cited by 225 · see citing works
Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor
Liu, Y., Chen, C., Qian, P., Lu, X., Sun, B., Zhang, X., Wang, L., Gao, X., Han, L., Chen, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms6988 · Cited by 204 · see citing works
Self-citationHan, X., Bai, Q., Yao, L., Liu, H., Gao, Y. P., Li, J., Liu, L., Liu, Y., Li, X., Lü, P., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201503344 · Cited by 204 · see citing works
Near-Infrared Upconversion Controls Photocaged Cell Adhesion
Li, W., Wang, J., Ren, J., & Qu, X. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412364m · Cited by 201 · see citing works
Li, D., Qin, W., Xu, B., Qian, J., & Tang, B. Z. (2017) · Advanced Materials · doi:10.1002/adma.201703643 · Cited by 175 · see citing works
Self-citationLi, C., Li, F., Zhang, Y., Zhang, W., Zhang, X., & Wang, Q. (2015) · ACS Nano · doi:10.1021/acsnano.5b05503 · Cited by 174 · see citing works
Li, C., Zhang, Y., Chen, G., Hu, F., Zhao, K., & Wang, Q. (2017) · Advanced Materials · doi:10.1002/adma.201605754 · Cited by 134 · see citing works
Qian, G., Zhong, Z., Luo, M., Yu, D., Zhang, Z., Ma, D., & Wang, Z. Y. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp809568a · Cited by 126 · see citing works
Sage, J. I., Uitert, R. L. V., & Duffy, T. E. (1984) · Stroke · doi:10.1161/01.str.15.1.46 · Cited by 98 · see citing works
Cai, X., Bandla, A., Mao, D., Feng, G., Qin, W., Liao, L., Thakor, N. V., Tang, B. Z., & Liu, B. (2016) · Advanced Materials · doi:10.1002/adma.201601191 · Cited by 90 · see citing works
Self-citationQian, G., Qi, J., Davey, J. A., Wright, J. S., & Wang, Z. Y. (2012) · Chemistry of Materials · doi:10.1021/cm300938s · Cited by 89 · see citing works
Self-citationWang, Y., Han, X., Wang, X., Li, J., Roe, A. W., Lü, P., & Qian, J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700685 · Cited by 72 · see citing works
Self-citationCarotid artery wall thickness: comparison between sonography and multi-detector row CT angiography
Saba, L., Sanfilippo, R., Montisci, R., & Mallarini, G. (2009) · Neuroradiology · doi:10.1007/s00234-009-0589-5 · Cited by 47 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Li, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,171 · see citing works
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 968 · see citing works
Recent Advances of Optical Imaging in the Second Near‐Infrared Window
Kenry, K., Duan, Y., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201802394 · Cited by 813 · see citing works
Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
Cai, X., & Liu, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000845 · Cited by 796 · see citing works
Design of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 794 · see citing works
Supramolecular materials based on AIE luminogens (AIEgens): construction and applications
Li, J., Wang, J., Li, H., Song, N., Wang, D., & Tang, B. Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00495e · Cited by 741 · see citing works
Self-citationMolecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection
Lei, Z., & Zhang, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007040 · Cited by 689 · see citing works
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582 · see citing works
Self-citationRotation Restricted Emission and Antenna Effect in Single Metal–Organic Frameworks
Yin, H., Wang, X., & Yin, X. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b06755 · Cited by 577 · see citing works
In vivo NIR-II fluorescence imaging for biology and medicine
Wang, F., Zhong, Y., Bruns, O., Liang, Y., & Dai, H. (2024) · Nature Photonics · doi:10.1038/s41566-024-01391-5 · Cited by 564 · see citing works
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 544 · see citing works
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 540 · see citing works
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510 · see citing works
Self-citationNIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer
Wang, P., Fan, Y., Lu, L., Liu, L., Fan, L., Zhao, M., Xie, Y., Xu, C., & Zhang, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05113-8 · Cited by 453 · see citing works
Atomic‐Precision Gold Clusters for NIR‐II Imaging
Liu, H., Hong, G., Luo, Z., Chen, J., Chang, J., Gong, M., He, H., Jiang, Y., Yuan, X. F., Li, L., et al. (2019) · Advanced Materials · doi:10.1002/adma.201901015 · Cited by 441 · see citing works
Li, Y., Cai, Z., Liu, S., Zhang, H., Wong, S. T. H., Lam, J. W. Y., Kwok, R. T. K., Qian, J., & Tang, B. Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15095-1 · Cited by 464 · see citing works
Self-citationCheng, H.-B., Li, Y., Tang, B. Z., & Yoon, J. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00326f · Cited by 393 · see citing works
Self-citationPerfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394 · see citing works
Self-citationAggregation-Induced Emission (AIE), Life and Health
Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 396 · see citing works
Self-citationOrganic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374 · see citing works
Self-citationWang, Q., Dai, Y.-N., Xu, J.-Z., Cai, J., Niu, X., Zhang, L., Chen, R.-F., Shen, Q.-M., Huang, W., & Fan, Q.-L. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901480 · Cited by 313 · see citing works
Zhu, S., Hu, Z., Tian, R., Yung, B. C., Yang, Q., Zhao, S., Kiesewetter, D. O., Niu, G., Sun, H., Antaris, A. L., et al. (2018) · Advanced Materials · doi:10.1002/adma.201802546 · Cited by 349 · see citing works
Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
Zhu, C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00600 · Cited by 346 · see citing works
Self-citationNIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 364 · see citing works
The Chemistry of Organic Contrast Agents in the NIR‐II Window
Mu, J., Xiao, M. W., Shi, Y., Geng, X., Li, H., Yin, Y., & Chen, X. S. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202114722 · Cited by 318 · see citing works
Yang, Y., Fan, X., Li, L., Yang, Y., Alifu, N., Xue, D., He, C., Qian, J., Hu, Q., Chen, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00043 · Cited by 306 · see citing works
Self-citationNear-Infrared-II (NIR-II) Bioimaging via Off-Peak NIR-I Fluorescence Emission
Zhu, S., Yung, B. C., Chandra, S., Niu, G., Antaris, A. L., & Chen, X. S. (2018) · Theranostics · doi:10.7150/thno.27995 · Cited by 304 · see citing works
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284 · see citing works
Self-citationStructural and process controls of AIEgens for NIR-II theranostics
Liu, S., Li, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2020) · Chemical Science · doi:10.1039/d0sc02911d · Cited by 276 · see citing works
Self-citationNIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274 · see citing works
Self-citationAggregation‐Induced Dual‐Phosphorescence from Organic Molecules for Nondoped Light‐Emitting Diodes
Wang, T., Su, X., Zhang, X., Nie, X., Huang, L., Zhang, X., Sun, X., Luo, Y., & Zhang, G. (2019) · Advanced Materials · doi:10.1002/adma.201904273 · Cited by 276 · see citing works
Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics
Tian, R., Zeng, Q., Zhu, S., Lau, J., Chandra, S., Ertsey, R. D., Hettie, K. S., Teraphongphom, N. T., Hu, Z., Niu, G., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw0672 · Cited by 268 · see citing works
Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery
Tian, R., Ma, H., Zhu, S., Lau, J., Ma, R., Liu, Y., Lin, L., Chandra, S., Wang, S., Zhu, X., et al. (2020) · Advanced Materials · doi:10.1002/adma.201907365 · Cited by 269 · see citing works
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging
Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201908125 · Cited by 266 · see citing works
Self-citationWang, S., Liu, L., Fan, Y., El‐Toni, A. M., Alhoshan, M. S., li, D., & Zhang, F. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b05148 · Cited by 252 · see citing works
NIR-II bioimaging of small organic molecule
Su, Y., Yu, B., Wang, S., Cong, H., & Shen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120717 · Cited by 251 · see citing works
Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging
Lin, J., Zeng, X., Xiao, Y., Tang, L., Nong, J., Liu, Y., Zhou, H., Ding, B., Xu, F., Tong, H., et al. (2018) · Chemical Science · doi:10.1039/c8sc04363a · Cited by 243 · see citing works
Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914397 · Cited by 242 · see citing works
Alifu, N., Zebibula, A., Qi, J., Zhang, H., Sun, C., Yu, X., Xue, D., Lam, J. W. Y., Li, G., Qian, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b05937 · Cited by 237 · see citing works
Self-citationLi, Y., Zeng, S., & Hao, J. (2019) · ACS Nano · doi:10.1021/acsnano.8b05431 · Cited by 228 · see citing works
Qi, J., Sun, C., Li, D., Zhang, H., Yu, W., Zebibula, A., Lam, J. W. Y., Xi, W., Zhu, L., Cai, F., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02452 · Cited by 226 · see citing works
Self-citationGuo, B., Feng, Z., Hu, D., Xu, S., Middha, E., Pan, Y., Liu, C., Zheng, H., Qian, J., Sheng, Z., et al. (2019) · Advanced Materials · doi:10.1002/adma.201902504 · Cited by 227 · see citing works
Self-citationAIE luminogens as fluorescent bioprobes
Niu, G., Zhang, R., Shi, X., Park, H., Xie, S., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.115769 · Cited by 226 · see citing works
Self-citationFeng, Z., Yu, X., Jiang, M., Zhu, L. J., Zhang, Y., Yang, W., Wang, X., Li, G., & Qian, J. (2019) · Theranostics · doi:10.7150/thno.31332 · Cited by 211 · see citing works
Self-citationRational Design of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing
Li, B., Zhao, M., & Zhang, F. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00157 · Cited by 205 · see citing works
Tang, Y., Li, Y., Hu, X., Zhao, H., Ji, Y., Chen, L., Hu, W., Zhang, W., Li, X., Lü, X., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801140 · Cited by 204 · see citing works
Yan, D., Wang, M., Wu, Q., Niu, N., Li, M., Song, R., Rao, J., Kang, M., Zhang, Z., Zhou, F., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202202614 · Cited by 187 · see citing works
Self-citationAcceptor engineering for NIR-II dyes with high photochemical and biomedical performance
Ji, A., Lou, H., Qu, C., Lu, W., Hao, Y., Li, J., Wu, Y., Chang, T., Chen, H., & Cheng, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31521-y · Cited by 183 · see citing works
Brightness of fluorescent organic nanomaterials
Ashoka, A. H., Aparin, I. O., Reisch, A., & Klymchenko, A. S. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00464j · Cited by 176 · see citing works
Recent advances in the development of NIR-II organic emitters for biomedicine
Li, J., Liu, Y., Xu, Y., Li, L., Sun, Y., & Huang, W. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213318 · Cited by 174 · see citing works
Zhu, D., Duo, Y., Suo, M., Zhao, Y., Xia, L., Zheng, Z., Yang, L., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003672 · Cited by 164 · see citing works
Self-citationSun, Y. M., Ding, F., Chen, Z., Zhang, R., Li, C., Xu, Y., Zhang, Y., Ni, R., Li, X., Yang, G., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908761116 · Cited by 163 · see citing works
Wang, J., Liu, Y., Morsch, M., Lu, Y., Shangguan, P., Han, L., Wang, Z., Chen, X., Song, C., Liu, S., et al. (2022) · Advanced Materials · doi:10.1002/adma.202106082 · Cited by 163 · see citing works
Self-citationNear‐Infrared‐II Quantum Dots for In Vivo Imaging and Cancer Therapy
Chen, L., Zhao, L., Wang, Z., Liu, S., & Pang, D. (2021) · Small · doi:10.1002/smll.202104567 · Cited by 163 · see citing works
Zhang, R., Xu, Y., Zhang, Y., Kim, H. S., Sharma, A. K., Gao, J., Yang, G., Kim, J. S., & Sun, Y. (2019) · Chemical Science · doi:10.1039/c9sc03504d · Cited by 159 · see citing works
Ding, F., Fan, Y., Sun, Y., & Zhang, F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900260 · Cited by 157 · see citing works
Tian, R., Ma, H., Yang, Q., Wan, H., Zhu, S., Chandra, S., Sun, H., Kiesewetter, D. O., Niu, G., Liang, Y., et al. (2018) · Chemical Science · doi:10.1039/c8sc03751e · Cited by 151 · see citing works
Chang, B., Chen, J., Bao, J., Sun, T., & Cheng, Z. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00401 · Cited by 154 · see citing works
Manipulating cell fate: dynamic control of cell behaviors on functional platforms
Li, W., Yan, Z., Ren, J., & Qu, X. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00053k · Cited by 151 · see citing works
Renal clearable Hafnium-doped carbon dots for CT/Fluorescence imaging of orthotopic liver cancer
Su, Y., Liu, S., Guan, Y., Xie, Z., Zheng, M. J., & Jing, X. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120110 · Cited by 151 · see citing works
Xu, Y., Zhang, Y., Li, J., An, J., Li, C., Bai, S., Sharma, A. K., Deng, G., Kim, J. S., & Sun, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120315 · Cited by 150 · see citing works
Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare
Qi, J., Chen, C., Ding, D., & Tang, B. Z. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800477 · Cited by 142 · see citing works
Self-citationRecent advances of AIE dots in NIR imaging and phototherapy
Zhang, R., Duan, Y., & Liu, B. (2019) · Nanoscale · doi:10.1039/c9nr06012j · Cited by 142 · see citing works
Zhang, L., Li, Y., Che, W., Zhu, D., Li, G., Xie, Z., Song, N., Liu, S., Tang, B. Z., Liu, X., et al. (2019) · Advanced Science · doi:10.1002/advs.201802050 · Cited by 141 · see citing works
Self-citationAlam, P., Climent, C., Alemany, P., & Laskar, I. R. (2019) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2019.100317 · Cited by 140 · see citing works
Chen, J., Chen, L., Wu, Y., Fang, Y., Zeng, F., Wu, S., & Zhao, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-27233-4 · Cited by 140 · see citing works
Boosting Fluorescence-Photoacoustic-Raman Properties in One Fluorophore for Precise Cancer Surgery
Qi, J., Li, J., Liu, R., Li, Q., Zhang, H., Lam, J. W. Y., Kwok, R. T. K., Liu, D., Ding, D., & Tang, B. Z. (2019) · Chem · doi:10.1016/j.chempr.2019.07.015 · Cited by 134 · see citing works
Self-citationSong, S., Wang, Y., Zhao, Y., Huang, W., Zhang, F., Zhu, S., Wu, Q., Fu, S., Tang, B. Z., & Wang, D. (2022) · Matter · doi:10.1016/j.matt.2022.06.030 · Cited by 133 · see citing works
Self-citationWang, Y., Zhang, Y., Wang, J., & Liang, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.004 · Cited by 133 · see citing works
Hu, X., Tang, Y., Hu, Y., Lu, F., Lü, X., Wang, Y., Li, J., Li, Y., Ji, Y., Wang, W., et al. (2019) · Theranostics · doi:10.7150/thno.34390 · Cited by 132 · see citing works
Wang, Q., Xu, J., Geng, R., Cai, J., Li, J., Xie, C., Tang, W., Shen, Q., Huang, W., & Fan, Q. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119671 · Cited by 131 · see citing works
Liu, S., Chen, R., Zhang, J., Li, Y., He, M., Fan, X., Zhang, H., Lu, X., Kwok, R. T. K., Lin, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c07527 · Cited by 129 · see citing works
Self-citationWang, Q., Xia, B., Xu, J., Niu, X., Cai, J., Shen, Q., Wang, W., Huang, W., & Fan, Q. (2019) · Materials Chemistry Frontiers · doi:10.1039/c9qm00036d · Cited by 127 · see citing works
Du, J., Wang, X., Sun, S., Wu, Y., Jiang, K., Li, S., & Lin, H. (2024) · Advanced Materials · doi:10.1002/adma.202314083 · Cited by 127 · see citing works
Li, B., Wang, W., Zhao, L., Yan, D., Li, X., Gao, Q., Zheng, J., Zhou, S., Lai, S., Feng, Y., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c10694 · Cited by 126 · see citing works
Self-citationNi, J., Zhang, P., Jiang, T., Chen, Y., Su, H., Wang, D., Yu, Z., Kwok, R. T. K., Zhao, Z., Lam, J. W. Y., et al. (2018) · Advanced Materials · doi:10.1002/adma.201805220 · Cited by 125 · see citing works
Self-citationLiu, P., Mu, X., Zhang, X., & Ming, D. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00610 · Cited by 123 · see citing works
Wang, H., & Liu, G. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00674a · Cited by 124 · see citing works
Wu, W., Yang, Y., Yang, Y., Yang, Y., Zhang, K., Guo, L., Ge, H., Chen, X., Liu, J., & Feng, H. (2019) · Small · doi:10.1002/smll.201805549 · Cited by 122 · see citing works
Recent Advances in Polymeric Nanoparticles for Enhanced Fluorescence and Photoacoustic Imaging
Ong, S. Y., Zhang, C., Dong, X., & Yao, S. Q. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202101964 · Cited by 120 · see citing works
Wan, H., Ma, H., Zhu, S., Wang, F., Tian, Y., Ma, R., Yang, Q., Hu, Z., Zhu, T., Wang, W., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804956 · Cited by 120 · see citing works
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine
Duo, Y., Han, L., Yang, Y., Wang, Z., Wang, L., Chen, J., Xiang, Z., Yoon, J., Luo, G., & Tang, B. Z. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00244 · Cited by 119 · see citing works
Self-citationBrain imaging with near-infrared fluorophores
Wang, H., Mu, X., Jiang, Y., Liang, Y., Zhang, X., & Ming, D. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.11.003 · Cited by 119 · see citing works
Meng, L., Jiang, S., Song, M., Yan, F., Zhang, W., Xu, B., & Tian, W. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c03714 · Cited by 119 · see citing works
NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates
Cai, Z., Zhu, L., Wang, M., Roe, A. W., Wang, X., & Qian, J. (2020) · Theranostics · doi:10.7150/thno.43533 · Cited by 113 · see citing works
Self-citationDifferent Strategies for Organic Nanoparticle Preparation in Biomedicine
Fang, F., Li, M., Zhang, J., & Lee, C. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00078 · Cited by 114 · see citing works
A short review on NIR-II organic small molecule dyes
Li, L., Dong, X., Li, J., & Wei, J. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108756 · Cited by 113 · see citing works
Ding, F., Chen, Z., Kim, W. Y., Sharma, A. K., Li, C., Ouyang, Q., Zhu, H., Yang, G., Sun, Y., & Kim, J. S. (2019) · Chemical Science · doi:10.1039/c9sc02466b · Cited by 112 · see citing works
Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness
Ma, H., Liu, C., Hu, Z., Yu, P., Zhu, X., Ma, R., Sun, Z., Zhang, C.-H., Sun, H., Zhu, S., et al. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b05159 · Cited by 110 · see citing works
Li, Y., Wu, Q., Kang, M., Song, N., Wang, D., & Tang, B. Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119749 · Cited by 108 · see citing works
Self-citationYu, L., Feng, L., Li, X., Li, S., Xu, Q., Pan, X., & Xiao, Y. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00134 · Cited by 106 · see citing works
Noncancerous disease-targeting AIEgens
Duo, Y., Luo, G., Zhang, W., Wang, R., Xiao, G. G., Li, Z., Li, X., Chen, M., Yoon, J., & Tang, B. Z. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00610c · Cited by 106 · see citing works
Self-citationDeng, Z., Bi, S., Jiang, M., & Zeng, S. (2021) · ACS Nano · doi:10.1021/acsnano.0c09799 · Cited by 106 · see citing works
Feng, Z., Bai, S., Qi, J., Sun, C., Zhang, Y., Yu, X., Ni, H., Wu, D., Fan, X., Xue, D., et al. (2021) · Advanced Materials · doi:10.1002/adma.202008123 · Cited by 106 · see citing works
Self-citationZhang, T., Zhang, J., Wang, F., Cao, H., Zhu, D., Chen, X., Xu, C., Yang, X., Huang, W., Wang, Z., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202110526 · Cited by 106 · see citing works
Self-citationKhan, M. S., Alqahtani, T., Shmrany, H. A., Gupta, G., Goh, K. W., Sahebkar, A., & Kesharwani, P. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214636 · Cited by 105 · see citing works
Carrier-free nano-integrated strategy for synergetic cancer anti-angiogenic therapy and phototherapy
Wei, Z., Liang, P., Xie, J., Song, C., Tang, C., Wang, Y., Yin, X., Cai, Y., Han, W., & Dong, X. (2019) · Chemical Science · doi:10.1039/c8sc04123g · Cited by 103 · see citing works
Ni, J., Min, T., Li, Y., Zha, M., Zhang, P., Ho, C. L., & Li, K. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001103 · Cited by 102 · see citing works
Chen, Y., Zhang, X., Cheng, D., Zhang, Y., Liu, Y., Ji, L., Guo, R., Chen, H., Ren, X., Chen, Z., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00118 · Cited by 102 · see citing works
Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
Cai, X., & Liu, B. (2020) · Angewandte Chemie · doi:10.1002/ange.202000845 · Cited by 102 · see citing works
- Authors
- Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- State Key Laboratory of Modern Optical Instruments (CN)
- Sir Run Run Shaw Hospital (CN)
- Nantong University (CN)
- Interdisciplinary Institute of Neuroscience and Technology (ZIINT) Zhejiang University Hangzhou 310020 China
- Corresponding author
- Qian, Jun
- Tang, Ben Zhong
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-01-17
- Volume
- 30
- Issue
- 12
- Pages
- e1706856-e1706856
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2786965675
- Cited by
- 418
- References
- 55
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 40 · 2023: 45 · 2022: 52 · 2021: 71 · 2020: 69 · 2019: 60 · 2018: 33
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (61275190)
- Natural Science Foundation of Zhejiang Province (LR17F050001)
- University Grants Committee (AoE/P‐03/08)
- Research Grants Council, University Grants Committee (16305015, 16308016, N‐HKUST604/14)
- Innovation and Technology Commission (ITC‐CNERC14SC01, ITCPD117‐9)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- aggregation-induced emission, blood-brain barrier disruption, tumor angiogenesis, enhanced permeability and retention effect, deep tissue penetration, biocompatibility, in vivo imaging
- MeSH terms
- Angiography, Animals, Brain, Fluorescence, Fluorescent Dyes, Radio Waves, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
