The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
ROS‐Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy
Open accessAbstract
The application of nanoparticles (NPs) to drug delivery has led to the development of novel nanotherapeutics for the treatment of various diseases including cancer. However, clinical use of NP‐mediated drug delivery has not always translated into improved survival of cancer patients, in part due to the suboptimal properties of NP platforms, such as premature drug leakage during preparation, storage, or blood circulation, lack of active targeting to tumor tissue and cells, and poor tissue penetration. Herein, an innovative reactive oxygen species (ROS)‐responsive polyprodrug is reported that can self‐assemble into stable NPs with high drug loading. This new NP platform is composed of the following key components: (i) polyprodrug inner core that can respond to ROS for triggered release of intact therapeutic molecules, (ii) polyethylene glycol (PEG) outer shell to prolong blood circulation; and (iii) surface‐encoded internalizing RGD (iRGD) to enhance tumor targeting and tissue penetration. These targeted ROS‐responsive polyprodrug NPs show significant inhibition of tumor cell growth both in vitro and in vivo.
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Cites
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Wang, J., Tang, W., Yang, M., Yin, Y., Li, H., Hu, F., Tang, L., Ma, X., Zhang, Y., & Wang, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120784 · Cited by 317
Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy
Li, Y., Zhou, J., Wang, L., & Xie, Z. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c08659 · Cited by 125
Self-citationROS-Activated Ratiometric Fluorescent Polymeric Nanoparticles for Self-Reporting Drug Delivery
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Metadata
- Authors
- Xu, X., Saw, P. E., Tao, W., Li, Y., Ji, X., Bhasin, S., Liu, Y., Ayyash, D., Rasmussen, J., Huo, M., Shi, J., & Farokhzad, O. C.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-07-06
- Volume
- 29
- Issue
- 33
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2727426256
- Cited by
- 499
- References
- 49
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, X., Saw, P. E., Tao, W., Li, Y., Ji, X., Bhasin, S., Liu, Y., Ayyash, D., Rasmussen, J., Huo, M., Shi, J., & Farokhzad, O. C. (2017). ROS‐Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy. Advanced Materials. https://doi.org/10.1002/adma.201700141
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