Conjugated Polymer for Voltage‐Controlled Release of Molecules
Open accessAbstract
Conjugated polymers are attractive in numerous biological applications because they are flexible, biocompatible, cost‐effective, solution‐processable, and electronic/ionic conductive. One interesting application is for controllable drug release, and this has been realized previously using organic electronic ion pumps. However, organic electronic ion pumps show high operating voltages and limited transportation efficiency. Here, the first report of low‐voltage‐controlled molecular release with a novel organic device based on a conjugated polymer poly(3‐hexylthiophene) is presented. The releasing rate of molecules can be accurately controlled by the duration of the voltage applied on the device. The use of a handy mobile phone to remotely control the releasing process and its application in delivering an anticancer drug to treat cancer cells are also successfully demonstrated. The working mechanism of the device is attributed to the unique switchable permeability of poly(3‐hexylthiophene) in aqueous solutions under a bias voltage that can tune the wettability of poly(3‐hexylthiophene) via oxidation or reduction processes. The organic devices are expected to find many promising applications for controllable drug delivery in biological systems.
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Common conductive polymers include polypyrrole (PPy), polyaniline along its derivatives poly(3,4-ethylenedioxythiophene) (PEDOT), which are widely used because of their biocompatibility and ability to convert electrical energy into mechanical energy.
“Common conductive polymers include polypyrrole (PPy), polyaniline along its derivatives poly(3,4-ethylenedioxythiophene) (PEDOT), which are widely used because of their biocompatibility and ability to convert electrical energy into mechanical energy.182,183”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [183]
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Cited by
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Recent Advances in Intelligent Wearable Medical Devices Integrating Biosensing and Drug Delivery
Tan, M., Xu, Y., Gao, Z., Yuan, T., Liu, Q., Yang, R., Zhang, B., & Peng, L. (2022) · Advanced Materials · doi:10.1002/adma.202108491 · Cited by 187 · see citing works
- Authors
- Liu, S., Fu, Y., Li, G., Li, L., Law, H. K., Chen, X., & Yan, F.
- Affiliations
- Hong Kong Polytechnic University (HK)
- Department of Health Technology and Informatics The Hong Kong Polytechnic University Hong Kong China
- University of Edinburgh (GB)
- Corresponding author
- Chen, Xianfeng
- Yan, Feng
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-07-14
- Volume
- 29
- Issue
- 35
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2732457780
- Cited by
- 47
- References
- 37
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 2 · 2017: 1
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advanced Materials (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (submittedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by-nc-nd)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc-nd)
- Funders
- Research Grants Council, University Grants Committee (C5015‐15G)
- Hong Kong Polytechnic University (1‐ZVGH, G‐SB07, G‐YBJ0, 1‐ZVK1)
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Organic Electronics and Photovoltaics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Molecular Junctions and Nanostructures
- Keywords
- conjugated polymers, poly(3-hexylthiophene), wettability control, redox reactions, remote drug delivery, anticancer drug delivery, organic electronic devices
- MeSH terms
- Delayed-Action Preparations, Ions, Polymers, Semiconductors, Wettability
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