The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy
Abstract
Bacterial infection is one of the most serious physiological conditions threatening human health. There is an increasing demand for more effective bacterial diagnosis and treatment through noninvasive theranostic approaches. Herein, a new strategy is reported to achieve in vivo metabolic labeling of bacteria through the use of MIL‐100 (Fe) nanoparticles (NPs) as the nanocarrier for precise delivery of 3‐azido‐d‐alanine (d‐AzAla). After intravenous injection, MIL‐100 (Fe) NPs can accumulate preferentially and degrade rapidly within the high H 2 O 2 inflammatory environment, releasing d‐AzAla in the process. d‐AzAla is selectively integrated into the cell walls of bacteria, which is confirmed by fluorescence signals from clickable DBCO‐Cy5. Ultrasmall photosensitizer NPs with aggregation‐induced emission characteristics are subsequently designed to react with the modified bacteria through in vivo click chemistry. Through photodynamic therapy, the amount of bacteria on the infected tissue can be significantly reduced. Overall, this study demonstrates the advantages of metal–organic‐framework‐assisted bacteria metabolic labeling strategy for precise bacterial detection and therapy guided by fluorescence imaging.
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Overcoming the Achilles' heel of photodynamic therapy
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Cited by
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Self-citationAggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Rejuvenated Photodynamic Therapy for Bacterial Infections
Jia, Q., Song, Q., Li, P., & Huang, W. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900608 · Cited by 426
Advanced Photosensitizer Activation Strategies for Smarter Photodynamic Therapy Beacons
Luby, B. M., Walsh, C. D., & Zheng, G. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201805246 · Cited by 420
The fast-growing field of photo-driven theranostics based on aggregation-induced emission
Zhang, Z., Kang, M., Tan, H., Song, N., Li, M., Xiao, P., Yan, D., Zhang, L., Wang, D., & Tang, B. Z. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01138c · Cited by 374
Metadata
- Authors
- Mao, D., Hu, F., Kenry, Ji, S., Wu, W., Ding, D., Kong, D., & Liu, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-03-05
- Volume
- 30
- Issue
- 18
- Pages
- e1706831-e1706831
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2792029853
- Cited by
- 334
- References
- 26
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mao, D., Hu, F., Kenry, Ji, S., Wu, W., Ding, D., Kong, D., & Liu, B. (2018). Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy. Advanced Materials. https://doi.org/10.1002/adma.201706831
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