The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Advanced Photosensitizer Activation Strategies for Smarter Photodynamic Therapy Beacons
Abstract
Photodynamic therapy (PDT) is a clinical treatment in which a light‐absorbing drug called a photosensitizer (PS) is combined with light and molecular oxygen to generate cytotoxic singlet oxygen. PDT provides additional tissue selectivity compared to conventional chemotherapy as singlet oxygen is generated only in areas in which PS accumulates and that are simultaneously illuminated by a light source with sufficient irradiance and dose. Early PDT beacons built on this concept by adding an analyte‐responsive element that simultaneously turns on PDT and fluorescence, providing both an additional layer of selectivity and real‐time feedback of the PS′s activation state. More recent PDT beacons have expanded this idea, with new methods now available for sensing analytes, generating singlet oxygen, and reporting treatment status. In this Minireview, we consider developments in advanced activation strategies implemented in therapeutic and theranostic beacons.
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Cites
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Cited by
Nguyen, V.-N., Qi, S., Kim, S., Kwon, N., Kim, G., Yim, Y., Park, S., & Yoon, J. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09220 · Cited by 457
BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen
Teng, K., Chen, W., Niu, L., Fang, W., Cui, G., & Yang, Q. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202106748 · Cited by 445
Liu, L., Zhang, J., An, R., Xue, Q., Cheng, X., Hu, Y., Huang, Z., Wu, L., Zeng, W., Miao, Y., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202217055 · Cited by 96
Gao, J., Chen, Z., Li, X., Yang, M., Lv, J., Li, H., & Yuan, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012556 · Cited by 61
Metadata
- Authors
- Luby, B. M., Walsh, C. D., & Zheng, G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-12-28
- Volume
- 58
- Issue
- 9
- Pages
- 2558-2569
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2808181737
- Cited by
- 420
- References
- 66
- FWCI
- 32.63
- Type
- journal article
- Language
- en
- Open access
- closed
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