The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Materials for Immunotherapy
Abstract
Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.
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Cites
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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
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Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
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Self-citationPolymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance
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Cited by
Cellular backpacks for macrophage immunotherapy
Shields, C. W., Evans, M. A., Wang, L. L.-W., Baugh, N., Iyer, S., Wu, D., Zhao, Z., Pusuluri, A., Ukidve, A., Pan, D. C., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz6579 · Cited by 414
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Metadata
- Authors
- Shields, C. W., Wang, L. L., Evans, M. A., & Mitragotri, S.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-06-28
- Volume
- 32
- Issue
- 13
- Pages
- e1901633-e1901633
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2953750576
- Cited by
- 193
- References
- 19
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
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