The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy
Abstract
Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next‐generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin‐modified MgO 2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg 2+. This reaction simultaneously produces abundant H 2 O 2 to induce cell death and damage the structure of transferrin to release Fe 3+, which will react with H 2 O 2 to produce highly toxic ·OH to kill tumor cells.
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Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723
Role of reactive oxygen species (ROS) in apoptosis induction
Simon, H.-U., Haj-Yehia, A., & Levi-Schaffer, F. (2000) · Apoptosis · doi:10.1023/a:1009616228304 · Cited by 2,774
Cited by
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Self-citationA Forward Vision for Chemodynamic Therapy: Issues and Opportunities
Zhao, P., Li, H., & Bu, W. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202210415 · Cited by 308
Self-citationLiu, B., Bian, Y., Liang, S., Yuan, M., Dong, S., He, F., Gai, S., Yang, P., Cheng, Z., & Lin, J. (2022) · ACS Nano · doi:10.1021/acsnano.1c07893 · Cited by 257
Metal peroxides for cancer treatment
He, J., Fu, L.-H., Qi, C., Lin, J., & Huang, P. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.026 · Cited by 93
A pH-activated autocatalytic nanoreactor for self-boosting Fenton-like chemodynamic therapy
Wu, H., Chen, F., Gu, D., You, C., & Sun, B. (2020) · Nanoscale · doi:10.1039/d0nr03135f · Cited by 79
Metadata
- Authors
- Tang, Z., Liu, Y., Ni, D., Zhou, J., Zhang, M., Zhao, P., Lv, B., Wang, H., Jin, D., & Bu, W.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-12-03
- Volume
- 32
- Issue
- 4
- Pages
- e1904011-e1904011
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2992594652
- Cited by
- 160
- References
- 2
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tang, Z., Liu, Y., Ni, D., Zhou, J., Zhang, M., Zhao, P., Lv, B., Wang, H., Jin, D., & Bu, W. (2020). Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy. Advanced Materials. https://doi.org/10.1002/adma.201904011
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