The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy
Abstract
Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity of nanozymes in the tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria‐like PEG/Ce‐Bi@DMSN nanozyme is developed by coating uniform Bi 2 S 3 nanorods (NRs) with dendritic mesoporous silica (Bi 2 S 3@DMSN) and then decorating ultrasmall ceria nanozymes into the large mesopores of Bi 2 S 3@DMSN. The nanozymes exhibit dual enzyme‐mimic catalytic activities (peroxidase‐mimic and catalase‐mimic) under acidic conditions that can regulate the TME, that is, simultaneously elevate oxidative stress and relieve hypoxia. In addition, the nanozymes can effectively consume the overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) is introduced to synergistically improve the dual enzyme‐mimicking catalytic activities and depletion of the overexpressed GSH in the tumors by photonic hyperthermia. This is achieved by taking advantage of the desirable light absorbance in the second near‐infrared (NIR‐II) window of the PEG/Ce‐Bi@DMSN nanozymes. Subsequently the reactive oxygen species (ROS)‐mediated therapeutic efficiency is significantly improved. Therefore, this study provides a proof of concept of hyperthermia‐augmented multi‐enzymatic activities of nanozymes for tumor ablation.
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Self-citationStimuli responsive nanosonosensitizers for sonodynamic therapy
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Metadata
- Authors
- Dong, S., Dong, Y., Jia, T., Liu, S., Liu, J., Yang, D., He, F., Gai, S., Yang, P., & Lin, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2020-09-11
- Volume
- 32
- Issue
- 42
- Pages
- e2002439-e2002439
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W3084621691
- Cited by
- 592
- References
- 58
- FWCI
- 31.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dong, S., Dong, Y., Jia, T., Liu, S., Liu, J., Yang, D., He, F., Gai, S., Yang, P., & Lin, J. (2020). GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy. Advanced Materials. https://doi.org/10.1002/adma.202002439
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