The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy
Open accessAbstract
Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as artificial enzymes in biomedicine. However, how to control their in vivo performance in a target cell is still challenging. Here we report a strategy to coordinate nanozymes to target tumor cells and selectively perform their activity to destruct tumors. We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive oxygen species regulation. We then introduce ferritin to guide nitrogen-doped porous carbon nanospheres into lysosomes and boost reactive oxygen species generation in a tumor-specific manner, resulting in significant tumor regression in human tumor xenograft mice models. Together, our study provides evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanozymes to target tumor cells for in vivo tumor catalytic therapy.
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Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Self-citationDetermination of subcutaneous tumor size in athymic (nude) mice
Tomayko, M. M., & Reynolds, C. P. (1989) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00300234 · Cited by 1,830
Wu, G., Santandreu, A., Kellogg, W., Gupta, S., Ogoke, O., Zhang, H., Wang, H.-L., & Dai, L. (2016) · Nano Energy · doi:10.1016/j.nanoen.2015.12.032 · Cited by 744
Cited by
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy
Li, S., Shang, L., Xu, B., Wang, S., Gu, K., Wu, Q., Sun, Y., Zhang, Q., Yang, H., Zhang, F., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904751 · Cited by 466
Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy
Xu, B., Cui, Y., Wang, W., Li, S., Lyu, C., Wang, S., Bao, W., Wang, H., Qin, M., Liu, Z., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003563 · Cited by 404
Bioinspired Copper Single‐Atom Catalysts for Tumor Parallel Catalytic Therapy
Lu, X., Gao, S., Lin, H., Yu, L., Han, Y., Zhu, P., Bao, W., Yao, H., Chen, Y., & Shi, J. (2020) · Advanced Materials · doi:10.1002/adma.202002246 · Cited by 367
Wang, M., Chang, M., Chen, Q., Wang, D., Li, C., Hou, Z., Lin, J., Jin, D., & Xing, B. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120093 · Cited by 322
Metadata
- Authors
- Fan, K., Xi, J., Fan, L., Wang, P., Zhu, C., Tang, Y., Xu, X., Liang, M., Jiang, B., Yan, X., & Gao, L.
- Venue
- Nature Communications
- Published
- 2018-04-12
- Volume
- 9
- Issue
- 1
- Pages
- 1440-1440
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2807191970
- Cited by
- 1,058
- References
- 3
- FWCI
- 37.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fan, K., Xi, J., Fan, L., Wang, P., Zhu, C., Tang, Y., Xu, X., Liang, M., Jiang, B., Yan, X., & Gao, L. (2018). In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy. Nature Communications. https://doi.org/10.1038/s41467-018-03903-8
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