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Cited by 274

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Prebiotics‐Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer

Zheng, Di‐Wei, Li, Run‐Qing, An, Jia‐Xin, Xie, Tian‐Qiu, Han, Zi‐Yi, Xu, Rui, Fang, Yu, Zhang, Xian‐Zheng·2020·Advanced Materials
DOI 10.1002/adma.202004529
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Abstract

While microbial‐based therapy has been considered as an effective strategy for treating diseases such as colon cancer, its safety remains the biggest challenge. Here, probiotics and prebiotics, which possess ideal biocompatibility and are extensively used as additives in food and pharmaceutical products, are combined to construct a safe microbiota‐modulating material. Through the host–guest chemistry between commercial Clostridium butyricum and chemically modified prebiotic dextran, prebiotics‐encapsulated probiotic spores (spores‐dex) are prepared. It is found that spores‐dex can specifically enrich in colon cancers after oral administration. In the lesion, dextran is fermented by C. butyricum , and thereby produces anti‐cancer short‐chain fatty acids (SCFAs). Additionally, spores‐dex regulate the gut microbiota, augment the abundance of SCFA‐producing bacteria (e.g., Eubacterium and Roseburia ), and markedly increase the overall richness of microbiota. In subcutaneous and orthotopic tumor models, drug‐loaded spores‐dex inhibit tumor growth up to 89% and 65%, respectively. Importantly, no obvious adverse effect is found. The work sheds light on the possibility of using a highly safe strategy to regulate gut microbiota, and provides a promising avenue for treating various gastrointestinal diseases.

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Research works printed but not linked: 32

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Metadata

Authors
Zheng, D., Li, R., An, J., Xie, T., Han, Z., Xu, R., Fang, Y., & Zhang, X.
Venue
Advanced Materials
Publisher
Wiley
Published
2020-10
Volume
32
Issue
45
ISSN
  • 0935-9648
  • 1521-4095
DOI
10.1002/adma.202004529
Cited by
274
References
11
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • National Natural Science Foundation of China (51833007, 51690152, 51988102)
  • National Basic Research Program of China (2019YFA0905603)

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