Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant
Open accessAbstract
bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. One of the patients died. Enhanced donor screening to limit the transmission of microorganisms that could lead to adverse infectious events and continued vigilance to define the benefits and risks of FMT across different patient populations are warranted.
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FMT may carry the risk of unintended introduction of pathogens and antibiotic-resistant microbes into recipients.
“FMT may also carry the risk of unintended introduction of pathogens and antibiotic-resistant microbes into the recipients.749,750”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [749]
In 2019, it was reported that in two independent clinical trials, two patients developed bacteremia with ESBL-producing Escherichia coli after receiving FMT from the same donor, and one patient died.
“In 2019, it was reported that in two independent clinical trials, two patients developed bacteremia with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli after receiving FMT from the same donor, and one patient died [136].”
From Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies (2022) · cites this paper as [136]
Transmission of an extended-spectrum beta-lactamase-producing Escherichia coli strain from a stool donor to two immunocompromised recipients caused bacteremia, with a fatal outcome in one case.
“This issue has become extremely timely after the transmission of an extended-spectrum b -lactamase-producing Escherichia coli strain from a stool donor to two immunocompromised recipients who developed bacteremia, with a fatal outcome in one case. 46”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [46]
Two cases of MDR bacteria transmission with life-threatening complications have been described in patients with cirrhosis and hematological malignancy after repeated FMT.
“Indeed, two cases of MDR bacteria transmission with life-threatening complications have been described in patients with cirrhosis and hematological malignancy after repeated FMT. 46”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [46]
FMT is generally recognized as safe, with no or limited side effects, but unexpected toxicity has been reported, including ESBL-producing Escherichia coli bacteremia in two patients who received FMT.
“Although FMT is generally recognized as safe, with no or limited side effects,33 unexpected toxicity has been reported, e.g., extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bacteremia in two patients who received FMT.34”
From <i>Faecalibacterium prausnitzii</i> strain EXL01 boosts efficacy of immune checkpoint inhibitors (2024) · cites this paper as [34]
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- Authors
- DeFilipp, Z., Bloom, P. P., Torres Soto, M., Mansour, M. K., Sater, M. R. A., Huntley, M. H., Turbett, S., Chung, R. T., Chen, Y.-B., & Hohmann, E. L.
- Affiliations
- Harvard University (US)
- From the Blood and Marrow Transplant Program (Z.D., Y.-B.C.), the Liver Center, Division of Gastroenterology (P.P.B., R.T.C.), and the Division of Infectious Diseases (M.T.S., M.K.M., S.T., E.L.H.), Massachusetts General Hospital, Harvard Medical School (Z.D., P.P.B., M.T.S., M.K.M., S.T., R.T.C., Y.-B.C., E.L.H.), and Day Zero Diagnostics (M.R.A.S., M.H.H.) — all in Boston.
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2019-11-21
- Volume
- 381
- Issue
- 21
- Pages
- 2043-2050
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2982566732
- Cited by
- 1,281
- References
- 26
- Citations by year
- 2026: 202 · 2025: 160 · 2024: 158 · 2023: 175 · 2022: 169 · 2021: 184 · 2020: 222 · 2019: 10
- FWCI
- 112.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- drug-resistant Escherichia coli, bacteremia, fecal microbiota transplantation, donor screening, genome sequencing
- MeSH terms
- Fecal Microbiota Transplantation, Aged, beta-Lactamases, Escherichia coli, Feces, Hepatic Encephalopathy, Humans, Male, Myelodysplastic Syndromes, Bacteremia, Fatal Outcome, Drug Resistance, Bacterial, Dysbiosis
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