Near‐Infrared‐II Fluorophore with Inverted Dependence of Fluorescence Quantum Yield on Polarity as Potent Phototheranostics for Fluorescence‐Image‐Guided Phototherapy of Tumors

Li, Mengyuan; Lu, Zhuoting; Zhang, Jiaxin; Chen, Liying; Tang, Xialian; Jiang, Quanheng; Hu, Qinglian; Li, Lin; Liu, Jie; Huang, Wei

doi:10.1002/adma.202209647

Cited by 56Nanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies

Near‐Infrared‐II Fluorophore with Inverted Dependence of Fluorescence Quantum Yield on Polarity as Potent Phototheranostics for Fluorescence‐Image‐Guided Phototherapy of Tumors

Li, Mengyuan, Lu, Zhuoting, Zhang, Jiaxin, Chen, Liying, Tang, Xialian, Jiang, Quanheng, Hu, Qinglian, Li, Lin +2 more·2023·Advanced Materials

DOI 10.1002/adma.202209647

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Abstract

Organic phototheranostics simultaneously having fluorescence in the second near‐infrared (NIR‐II, 1000–1700 nm) window, and photothermal and photodynamic functions possess great prospects in tumor diagnosis and therapy. However, such phototheranostics generally suffer from low brightness and poor photodynamic performance due to severe solvatochromism. Herein, an organic NIR‐II fluorophore AS1, which possesses an inverted dependence of fluorescence quantum yield on polarity, is reported to serve as potent phototheranostics for tumor diagnosis and therapy. After encapsulation of AS1 into nanostructures, the obtained phototheranostics (AS1 R) exhibit high extinction coefficients (e.g., 68200 L mol−1 cm−1 at 808 nm), NIR‐II emission with high fluorescence quantum yield up to 4.7% beyond 1000 nm, photothermal conversion efficiency of ≈65%, and 1 O 2 quantum yield up to 4.1%. The characterization of photophysical properties demonstrates that AS1 R is superior to other types of organic phototheranostics in brightness, photothermal effect, and photodynamic performance at the same mass concentration. The excellent phototheranostic performance of AS1 R enables clear visualization and complete elimination of tumors using a single and low injection dose. This study demonstrates the merits and prospects of NIR‐II fluorophore with inverted polarity dependence of fluorescence quantum yield as high‐performance phototheranostic agents for fluorescence imaging and phototherapy of tumors.

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The absorption and emission of 4F originate primarily from its extensive π-conjugation rather than from a conventional charge-transfer state.
“This is consistent with the minimal solvation effect (Fig. S14), indicating that the absorption and emission of 4F originate primarily from its extensive π-conjugation, rather than from the conventional charge-transfer (CT) state typically observed in traditional D-A NIR-II fluorophores33.”
From Alleviating NIR-II emission quenching in ring-fused fluorophore via manipulating dimer populations for superior fluorescence imaging (2025) · cites this paper as [33]

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Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging
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Acceptor planarization and donor rotation strategy balance radiation and nonradiation decay for achieving highly efficient phototheranostic agents
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Regioisomerization of bromine atom on end group to enhance photodynamic activity of A−D−A photosensitizer
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Additional file 1 of A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy
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Authors: Li, M., Lu, Z., Zhang, J., Chen, L., Tang, X., Jiang, Q., Hu, Q., Li, L., Liu, J., & Huang, W.
Affiliations: Nanjing Tech University (CN)
Zhejiang University of Technology (CN)
Northwestern Polytechnical University (CN)
Corresponding author: Hu, Qinglian
Li, Lin
Liu, Jie
Huang, Wei
ORCID: Li, Mengyuan
Zhang, Jiaxin
Chen, Liying
Hu, Qinglian
Li, Lin
Liu, Jie
Huang, Wei
Venue: Advanced Materials
Publisher: Wiley
Published: 2023-10-09
Volume: 35
Issue: 45
Pages: e2209647-e2209647
ISSN: 0935-9648 (ISSN-L)
1521-4095
DOI: 10.1002/adma.202209647
OpenAlex: W4384663007
Cited by: 56
References: 88
Citations by year: 2026: 7 · 2025: 24 · 2024: 23 · 2023: 2
FWCI: 4.42
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Materials (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (22275087, 22077101)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Keywords: fluorescence quantum yield, phototheranostics, photothermal therapy, photodynamic therapy, singlet oxygen generation, tumor imaging, nanoencapsulation
MeSH terms: Theranostic Nanomedicine, Fluorescence, Fluorescent Dyes, Humans, Neoplasms, Phototherapy, Cell Line, Tumor, Nanoparticles

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Near‐Infrared‐II Fluorophore with Inverted Dependence of Fluorescence Quantum Yield on Polarity as Potent Phototheranostics for Fluorescence‐Image‐Guided Phototherapy of Tumors

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