Cited by 55Luminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPhotochemistry and Electron Transfer Studies

Excimer‐Mediated Ultrafast Intermolecular Nonradiative Decay Enables Giant Photothermal Performance for Optimized Phototheranostic

Miao, Xiaofei, Yao, Weiyun, Chen, Ruizhe, Jia, Mingxuan, Ren, Can, Zhao, Hui, He, Tingchao, Fan, Quli +1 more·2023·Advanced Materials

Abstract

Developing organic photothermal materials (OPMs) with high photothermal performance for phototheranostic mainly focus on the manipulation of intramolecular nonradiative ( intra NR) decay, which often requires quite complicated and time‐consuming molecular engineering. In addition to intra NR decay, intermolecular nonradiative ( inter NR) decay is equally important and more convenient in governing photothermal performance. However, controlling inter NR decay remains challenging due to the limited understanding of their origin and dynamics. Here, systemic investigation of intra NR and inter NR decay directs the first demonstration of simple manipulation of inter NR decay to produce a giant photothermal performance for optimized phototheranostic. Among three designed polymers with varying fluorine substitution, structure–performance studies reveal a dimer‐initiated inter NR decay to improve photothermal performance. Dimer is formed by intermolecular CF···H hydrogen bond. This finding inspires a simple aggregation control strategy to form excited dimer, namely, excimer. It initiates an ≈100‐fold enhancement in inter NR decay rate over conventional intra NR decay to produce ultrahigh photothermal conversion efficiency of 81% for efficient photoacoustic imaging‐guided photothermal therapy in vivo. This study provides insights into inter NR decay in achieving a giant photothermal effect and paves a convenient way to develop high‐performance OPMs.

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Crossref · 10.1002/adma.202301739

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Authors
Miao, X., Yao, W., Chen, R., Jia, M., Ren, C., Zhao, H., He, T., Fan, Q., & Hu, W.
Affiliations
  • Northwestern Polytechnical University (CN)
  • Nanjing University of Posts and Telecommunications (CN)
  • Shenzhen University (CN)
Corresponding author
  • He, Tingchao
  • Fan, Quli
  • Hu, Wenbo
Venue
Advanced Materials
Publisher
Wiley
Published
2023-05-26
Volume
35
Issue
30
Pages
e2301739-e2301739
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W4368361628
Cited by
55
References
32
Citations by year
2026: 17 · 2025: 19 · 2024: 17 · 2023: 2
FWCI
4.05
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (62175201, 61805118)
  • Natural Science Foundation of Ningbo (2021J043)
  • Fundamental Research Funds for the Central Universities
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
Keywords
excimer formation, fluorine substitution, dimerization, aggregation control, photothermal conversion efficiency, photothermal therapy, photoacoustic imaging, phototheranostics

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