Excimer‐Mediated Ultrafast Intermolecular Nonradiative Decay Enables Giant Photothermal Performance for Optimized Phototheranostic
Abstract
Developing organic photothermal materials (OPMs) with high photothermal performance for phototheranostic mainly focus on the manipulation of intramolecular nonradiative ( intra NR) decay, which often requires quite complicated and time‐consuming molecular engineering. In addition to intra NR decay, intermolecular nonradiative ( inter NR) decay is equally important and more convenient in governing photothermal performance. However, controlling inter NR decay remains challenging due to the limited understanding of their origin and dynamics. Here, systemic investigation of intra NR and inter NR decay directs the first demonstration of simple manipulation of inter NR decay to produce a giant photothermal performance for optimized phototheranostic. Among three designed polymers with varying fluorine substitution, structure–performance studies reveal a dimer‐initiated inter NR decay to improve photothermal performance. Dimer is formed by intermolecular CF···H hydrogen bond. This finding inspires a simple aggregation control strategy to form excited dimer, namely, excimer. It initiates an ≈100‐fold enhancement in inter NR decay rate over conventional intra NR decay to produce ultrahigh photothermal conversion efficiency of 81% for efficient photoacoustic imaging‐guided photothermal therapy in vivo. This study provides insights into inter NR decay in achieving a giant photothermal effect and paves a convenient way to develop high‐performance OPMs.
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The femtosecond component suggests a deactivation preference over all other decay pathways within 4F NP1s, highlighting an intense intermolecular nonradiative decay that reduces emission.
“Notably, this femtosecond component suggests a deactivation preference over all other decay pathways within 4F NP1s, highlighting an intense interNR decay that reduces emission39,40.”
From Alleviating NIR-II emission quenching in ring-fused fluorophore via manipulating dimer populations for superior fluorescence imaging (2025) · cites this paper as [39]
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- Authors
- Miao, X., Yao, W., Chen, R., Jia, M., Ren, C., Zhao, H., He, T., Fan, Q., & Hu, W.
- Affiliations
- Northwestern Polytechnical University (CN)
- Nanjing University of Posts and Telecommunications (CN)
- Shenzhen University (CN)
- Corresponding author
- He, Tingchao
- Fan, Quli
- Hu, Wenbo
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2023-05-26
- Volume
- 35
- Issue
- 30
- Pages
- e2301739-e2301739
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W4368361628
- Cited by
- 55
- References
- 32
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 17 · 2023: 2
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (62175201, 61805118)
- Natural Science Foundation of Ningbo (2021J043)
- Fundamental Research Funds for the Central Universities
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Keywords
- excimer formation, fluorine substitution, dimerization, aggregation control, photothermal conversion efficiency, photothermal therapy, photoacoustic imaging, phototheranostics
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