Efficient Cisplatin Pro-Drug Delivery Visualized with Sub-100 nm Resolution: Interfacing Engineered Thermosensitive Magnetomicelles with a Living System
Open accessAbstract
Temperature‐responsive magnetic nanomicelles can serve as thermal energy and cargo carriers with controlled drug release functionality. In view of their potential biomedical applications, understanding the modes of interaction between nanomaterials and living systems and evaluation of efficiency of cargo delivery is of the utmost importance. In this work, we investigate the interaction between the hybrid magnetic nanomicelles engineered for controlled platinum complex drug delivery and a biological system at three fundamental levels: subcellular compartments, a single cell and whole living animal. Nanomicelles with polymeric P(NIPAAm‐co‐AAm)‐b‐PCL core‐shell were loaded with a hydrophobic Pt(IV) complex and Fe3O4 nanoparticles though self‐assembly. The distribution of a platinum complex on subcellular level is visualized using hard X‐ray fluorescence microscopy with unprecedented level of detail at sub‐100 nm spatial resolution. We then study the cytotoxic effects of platinum complex‐loaded micelles in vitro on a head and neck cancer cell culture model SQ20B. Finally, by employing the magnetic functionality of the micelles and additionally loading them with a near infrared fluorescent dye, we magnetically target them to a tumor site in a live animal xenografted model which allows to visualize their biodistribution in vivo.
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Magnetically targeting nanomicelles to a cancer site in a live animal xenografted model was demonstrated using magnetic functionality in the presence of a near-infrared fluorescent dye.
“taking the advantage of magnetic functionality nanomicelles in the presence of a near-infrared fluorescent dye, magnetically targeting them to a cancer site in a live animal xenografted model was demonstrated.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [176]
Novel polymeric materials were self-assembled into nanomicelles with a core-shell structure and encapsulated with a hydrophobic Pt (IV) complex and Fe3O4 nanoparticles.
“Novel polymeric materials were self-assembly into nanomicelles with a core-shell structure and encapsulated with a hydrophobic Pt (IV) complex and Fe3O4 nanoparticles.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [176]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
Tomitaka, A., Vashist, A., Kolishetti, N., & Nair, M. (2023) · Nanoscale Advances · doi:10.1039/d3na00180f · Cited by 45 · see citing works
- Authors
- Vitol, E. A., Rozhkova, E. A., Rose, V., Stripe, B. D., Young, N. R., Cohen, E. E. W., Leoni, L., & Novosad, V.
- Affiliations
- Argonne National Laboratory (US)
- University of Chicago (US)
- Corresponding author
- Rozhkova, Elena A.
- ORCID
- Venue
- Advanced Materials Interfaces
- Publisher
- Wiley
- Published
- 2014-06-06
- Volume
- 1
- Issue
- 7
- ISSN
- 2196-7350 (ISSN-L)
- OpenAlex
- W2076345816
- Cited by
- 24
- References
- 52
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.osti.gov
- Locations
- Advanced Materials Interfaces (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- U.S. Department of Energy (AC02‐06CH11357, 06CH11357, DE-AC02-)
- University of Chicago (DE-AC02-06CH11357)
- Office of Science (AC02‐06CH11357, DE-AC02, 06CH11357, DE-AC02-06CH11357)
- Basic Energy Sciences (DE-AC02, AC02‐06CH11357, 06CH11357)
- Argonne National Laboratory (DE- AC02-06-CH11357, DE-AC02, AC02–06CH11357, 06CH11357)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- Fe3O4 nanoparticles, platinum(IV) complexes, subcellular drug distribution, head and neck cancer, near-infrared fluorescence, tissue distribution, controlled drug release, self-assembly
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