Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes
Abstract
Increased contrast in magnetic resonance imaging (MRI) is accomplished using polymeric micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles encapsulated in biocompatible, biodegradable poly(ϵ-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) copolymers (see Figure). The loaded micelles show significantly improved T2 relaxivities and remarkable MRI detection sensitivity.
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Iron oxide nanoparticles can be entrapped inside vesicles like liposomes or polymeric micelles.
“Iron oxide nanoparticles can be entrapped inside of vesicles like liposomes [94–97] or polymeric micelles [98–101].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [100]
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- Authors
- Ai, H., Flask, C., Weinberg, B., Shuai, X. ‐., Pagel, M. D., Farrell, D., Duerk, J., & Gao, J.
- Affiliations
- Case Western Reserve University (US)
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2005-08-04
- Volume
- 17
- Issue
- 16
- Pages
- 1949-1952
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2076338426
- Cited by
- 465
- References
- 17
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 14 · 2020: 20 · 2019: 31 · 2018: 20 · 2017: 24 · 2016: 34 · 2015: 37 · 2014: 35 · 2013: 34 · 2012: 44
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- polymeric micelles, superparamagnetic iron oxide nanoparticles, magnetite, MRI contrast agents, T2 relaxivity, biodegradable polymers
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