Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Abstract
Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
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Low-density lipoprotein receptor-related protein is a transmembrane glycoprotein that can mediate the uptake of cholesterol-rich low-density lipoprotein, including cholesterol, tocopherol, and Apos.
“Low-density lipoprotein receptor-related protein (LRP) as a transmembrane glycoprotein can mediate the uptake of cholesterol-rich low-density lipoprotein, including cholesterol, tocopherol, and Apos.180”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [180]
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- Authors
- Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W., & Schneider, W. J.
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1985-11
- Volume
- 1
- Issue
- 1
- Pages
- 1-39
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W2138466097
- Cited by
- 1,600
- References
- 0
- Citations by year
- 2026: 1 · 2025: 12 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 23 · 2020: 15 · 2019: 13 · 2018: 12 · 2017: 18 · 2016: 28 · 2015: 25 · 2014: 22 · 2013: 23 · 2012: 24
- FWCI
- 39.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-20948, HL 31346, HL 01287)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- receptor-mediated endocytosis, LDL receptor, phase separation, liquid-liquid phase separation, membrane compartments, cytoplasmic compartments
- MeSH terms
- Animals, Cloning, Molecular, Coated Pits, Cell-Membrane, Endocytosis, Gene Expression Regulation, Humans, Lipoproteins, LDL, Mutation, Receptors, LDL, Endosomes, Structure-Activity Relationship
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