A Bioactive Living Hydrogel: Photosynthetic Bacteria Mediated Hypoxia Elimination and Bacteria-Killing to Promote Infected Wound Healing
Abstract
Abstract Disruption and vasoconstriction of the blood vessels that results in tissue hypoxia can retard the wound healing process. Transcutaneous oxygen delivery for the hypoxic tissue has been shown to be an effective method for enhanced wound regeneration, for example, hyperbaric oxygen therapy and topical oxygen therapy. However, these techniques' clinical applications are limited by high cost and complicated protocols. To combat this, a bioactive living hydrogel based on photosynthetic microorganisms is designed for enhanced wound healing by production and local delivery of oxygen to alleviate acute and chronic tissue hypoxia. Spirulina platensis (SP), a type of photosynthetic bacteria is coated with the natural polymer carboxymethyl chitosan to obtain the SP gel, which keeps the oxygen generation capability of the SP while promoting its adhesion to the infected wound. Moreover, chlorophyll, a natural photosensitizer, is released from the SP irradiated with 650‐nm laser, and generates reactive oxygen species, thereby causing photodynamic destruction of bacteria in the infectious area. Cytotoxicity assays and in vivo toxicity assessment demonstrate the excellent biocompatibility of the gel. The SP gel is easy to obtain, cheap for mass production, and convenient for usage, which is promising for clinical application.
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A living hydrogel containing carboxymethyl chitosan-coated S. platensis kept O2 generation capability while promoting adhesion to infected wounds in a mouse model, and chlorophyll produced ROS under 650-nm laser leading to photodynamic eradication of S. aureus-infected skin.
“Additionally, chlorophyll, acting as a photosensitizer, produced ROS when exposed to a 650-nm laser, leading to the photodynamic eradication of S. aureus-infected skin.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [165]
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- Authors
- Li, W., Wang, S., Zhong, D., Du, Z., & Zhou, M.
- Affiliations
- Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Corresponding author
- Zhou, Min
- Venue
- Advanced Therapeutics
- Publisher
- Wiley
- Published
- 2020-07-30
- Volume
- 4
- Issue
- 1
- ISSN
- 2366-3987 (ISSN-L)
- OpenAlex
- W3046458014
- Cited by
- 88
- References
- 44
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 20 · 2023: 24 · 2022: 9 · 2021: 8
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Therapeutics (publishedVersion)
- Funders
- National Basic Research Program of China (2018YFC0115701)
- National Natural Science Foundation of China (81671748, 51971200, 81971667)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- photosynthetic bacteria, Spirulina platensis, tissue hypoxia, infected wound healing, carboxymethyl chitosan, antimicrobial photodynamic therapy, reactive oxygen species, wound dressings, biocompatibility
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