The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reactive‐Oxygen‐Species‐Responsive Drug Delivery Systems: Promises and Challenges
Open accessAbstract
Given the increasing evidence indicates that many pathological conditions are associated with elevated reactive oxygen species (ROS) levels, there have been growing research efforts focused on the development of ROS‐responsive carrier systems because of their promising potential to realize more specific diagnosis and effective therapy. By judicious utilization of ROS‐responsive functional moieties, a wide range of carrier systems has been designed for ROS‐mediated drug delivery. In this review article, insights into design principle and recent advances on the development of ROS‐responsive carrier systems for drug delivery applications are provided alongside discussion of their in vitro and in vivo evaluation. In particular, the discussions in this article will mainly focus on polymeric nanoparticles, hydrogels, inorganic nanoparticles, and activatable prodrugs that have been integrated with diverse ROS‐responsive moieties for spatiotemporally controlled release of drugs for effective therapy.
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Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Micellar Nanocarriers: Pharmaceutical Perspectives
Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
Reactive oxygen species in tumor metastasis
Nishikawa, M. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.031 · Cited by 398
Cited by
Hydrogels and Their Applications in Targeted Drug Delivery
Narayanaswamy, R., & Torchilin, V. P. (2019) · Molecules · doi:10.3390/molecules24030603 · Cited by 664
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Carbon-based nanomaterials as an emerging platform for theranostics
Patel, K. D., Singh, R. K., & Kim, H.-W. (2019) · Materials Horizons · doi:10.1039/c8mh00966j · Cited by 555
ROS‐Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy
Xu, X., Saw, P. E., Tao, W., Li, Y., Ji, X., Bhasin, S., Liu, Y., Ayyash, D., Rasmussen, J., Huo, M., et al. (2017) · Advanced Materials · doi:10.1002/adma.201700141 · Cited by 499
Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment
Zhang, M., Hu, W., Cai, C., Wu, Y., Li, J., & Dong, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100223 · Cited by 394
Metadata
- Authors
- Saravanakumar, G., Kim, J., & Kim, W. J.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2016-06-08
- Volume
- 4
- Issue
- 1
- Pages
- 1600124-1600124
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W2410933689
- Cited by
- 675
- References
- 5
- FWCI
- 18.42
- Type
- journal article
- Language
- en
- Open access
- gold
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