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Synthesis and Optimization of MoS2@Fe3O4‐ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser

Open access
Liu, Bei, Li, Chunxia, Chen, Guanying, Liu, Bin, Deng, Xiaoran, Wei, Yi, Xia, Jun, Xing, Bengang, Ma, Ping'an, Lin, Jun·2017·Advanced Science

Abstract

Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS 2 nanoflowers with a broad size range of 80–180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS 2 nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS 2@Fe 3 O 4‐ICG/Pt(IV) (labeled as Mo@Fe‐ICG/Pt) is designed by covalently grafting Fe 3 O 4 nanoparticles with polyethylenimine (PEI) functionalized MoS 2, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS 2@Fe 3 O 4. The resulting Mo@Fe‐ICG/Pt nanocomposites can achieve excellent magnetic resonance/infrared thermal/photoacoustic trimodal biomaging as well as remarkably enhanced antitumor efficacy of combined photothermal therapy, photodynamic therapy, and chemotherapy triggered by a single 808 nm NIR laser, thus leading to an ideal nanoplatform for cancer diagnosis and treatment in future.

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Metadata

Authors
Liu, B., Li, C., Chen, G., Liu, B., Deng, X., Wei, Y., Xia, J., Xing, B., Ma, P., & Lin, J.
Venue
Advanced Science
Publisher
Wiley
Published
2017-04-10
Volume
4
Issue
8
Pages
1600540-1600540
ISSN
2198-3844 (ISSN-L)
OpenAlex
W2606734676
Cited by
316
References
4
FWCI
15.13
Type
journal article
Language
en
Status
Retracted
Open access
gold

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CoChat. (2026). Citation check: Synthesis and Optimization of MoS2@Fe3O4‐ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser. https://app.cochat.ai/papers/10.1002/advs.201600540
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Liu, B., Li, C., Chen, G., Liu, B., Deng, X., Wei, Y., Xia, J., Xing, B., Ma, P., & Lin, J. (2017). Synthesis and Optimization of MoS2@Fe3O4‐ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser. Advanced Science. https://doi.org/10.1002/advs.201600540

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.