Biodegradable Medical Implants: Reshaping Future Medical Practice

Xia, Bo; Liu, Yan; Xing, Yangkun; Shi, Zhewei; Pan, Xiaocheng

doi:10.1002/advs.202508014

Cited by 64biodegradable polymer synthesis and propertiesMagnesium Alloys: Properties and ApplicationsBone Tissue Engineering Materials

Biodegradable Medical Implants: Reshaping Future Medical Practice

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Xia, Bo, Liu, Yan, Xing, Yangkun, Shi, Zhewei, Pan, Xiaocheng·2025·Advanced Science

DOI 10.1002/advs.202508014PMC PMC12462970

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Abstract

Biodegradable medical implants have fundamentally transformed the field of biomedical engineering by providing sustainable and biocompatible alternatives that obviate the need for secondary surgical removal and facilitate endogenous tissue regeneration. This comprehensive review systematically evaluates recent advancements in biodegradable implants utilized across a spectrum of medical applications, including internal medicine, surgical interventions, and medical devices. The developments discussed herein signify substantial progress in material synthesis, characterization, and processing techniques, effectively addressing critical challenges associated with the integration of biodegradable devices into medical implants. Although biodegradable medical implants promise advanced patient care, widespread clinical translation is hindered by inconsistent degradation rates mismatched with healing timelines, insufficient load‐bearing strength, and potential inflammatory or toxic by‐products. Additionally, most studies exhibit application‐material imbalances, inadequate in vivo validation, and poorly controlled degradation behavior. Future efforts must clarify degradation mechanisms and treat materials as therapeutic agents. By synthesizing recent findings and highlighting critical gaps, this review provides valuable insights to guide innovation in biodegradable implant technologies, ultimately enhancing clinical outcomes and accelerating regenerative medicine's progress. Addressing these challenges is crucial for realizing their full clinical potential.

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An optimal biodegradable implant should degrade substantially only after fulfilling its mechanical role during fracture healing, necessitating a degradation rate that aligns with the bone healing process.
“Actually, an optimal biodegradable implant should degrade substantially only after fulfilling its mechanical role during the fracture healing period, necessitating a degradation rate that aligns with the bone healing process42–44.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [43]

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Sorted by citations

Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture
Qi, G., Ma, T., Wang, Y., Chen, K., Yan, Y., Li, Z., Deng, N., Tseng, C., Li, B., Zheng, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72683-3 · Cited by 2 · see citing works

Authors: Xia, B., Liu, Y., Xing, Y., Shi, Z., & Pan, X.
Affiliations: Zhejiang A & F University (CN)
Zhuji People's Hospital of Zhejiang Province Zhuji 311800 China
Department of Bioenvironment Jiyang College of Zhejiang A&F University Zhuji 311800 China
Corresponding author: Xia, Bo
Shi, Zhewei
ORCID: Xia, Bo
Liu, Yan
Venue: Advanced Science
Publisher: Wiley
Published: 2025-08-09
Volume: 12
Issue: 35
Pages: e08014-e08014
ISSN: 2198-3844 (ISSN-L)
DOI: 10.1002/advs.202508014
PMC: PMC12462970
OpenAlex: W4413055830
Cited by: 64
References: 126
Citations by year: 2026: 56 · 2025: 8
FWCI: 3.72
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Advanced Science (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords: biodegradable polymers, controlled degradation, tissue regeneration, biocompatibility, degradation mechanism, load-bearing strength, clinical translation, regenerative medicine, implant materials
MeSH terms: Animals, Biocompatible Materials, Biomedical Engineering, Humans, Prostheses and Implants, Absorbable Implants, Tissue Engineering, Regenerative Medicine

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