Cited by 242Erythropoietin and Anemia TreatmentIron Metabolism and DisordersBlood transfusion and management

Diagnosis and Treatment of Cancer-Related Anemia

Gilreath, Jeffrey A., Stenehjem, David D., Rodgers, George M.·2014·American Journal of Hematology

Abstract

Cancer-related anemia (CRA) is due to multiple etiologies, including chemotherapy-induced myelosuppression, blood loss, functional iron deficiency, erythropoietin deficiency due to renal disease, marrow involvement with tumor as well as other factors. The most common treatment options for CRA include iron therapy, erythropoietic-stimulating agents (ESAs), and red cell transfusion. Safety concerns as well as restrictions and reimbursement issues surrounding ESA therapy for CRA have resulted in suboptimal treatment. Similarly, many clinicians are not familiar or comfortable using intravenous iron products to treat functional iron deficiency associated with CRA. This article summarizes our approach to treating CRA and discusses commonly encountered clinical scenarios for which current clinical guidelines do not apply.

Integrity signals

Registry

Crossref · 10.1002/ajh.23628

Cites

98 of 98 references verified0 citation errors · 0 not checkable

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  • Even if tumor tissue would be optimally vascularized, systemic hypoxia could lead to tumor tissue hypoxia in cancer patients.

    “Even if tumor tissue would be optimally vascularized, systemic hypoxia could also lead to tumor tissue hypoxia in cancer patients.”

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Authors
Gilreath, J. A., Stenehjem, D. D., & Rodgers, G. M.
Affiliations
  • Huntsman Cancer Institute (US)
  • University of Utah (US)
  • University of Utah Hospital (US)
Corresponding author
Rodgers, George M.
Venue
American Journal of Hematology
Publisher
Wiley
Published
2014-02
Volume
89
Issue
2
Pages
203-212
ISSN
  • 0361-8609 (ISSN-L)
  • 1096-8652
OpenAlex
W1507600704
Cited by
242
References
98
Citations by year
2026: 15 · 2025: 21 · 2024: 26 · 2023: 23 · 2022: 28 · 2021: 25 · 2020: 20 · 2019: 20 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 11 · 2014: 7
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Hematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Society of Clinical Oncology
  • Huntsman Cancer Institute
  • National Comprehensive Cancer Network
Topics
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
Keywords
cancer-related anemia, chemotherapy-induced myelosuppression, functional iron deficiency, erythropoietin deficiency, kidney disease, erythropoiesis-stimulating agents, intravenous iron, red blood cell transfusion
MeSH terms
Anemia, Erythropoietin, Humans, Iron, Neoplasms, Prevalence, Treatment Outcome, Erythrocyte Transfusion, Malnutrition

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