Diagnosis and Treatment of Cancer-Related Anemia
Abstract
Cancer-related anemia (CRA) is due to multiple etiologies, including chemotherapy-induced myelosuppression, blood loss, functional iron deficiency, erythropoietin deficiency due to renal disease, marrow involvement with tumor as well as other factors. The most common treatment options for CRA include iron therapy, erythropoietic-stimulating agents (ESAs), and red cell transfusion. Safety concerns as well as restrictions and reimbursement issues surrounding ESA therapy for CRA have resulted in suboptimal treatment. Similarly, many clinicians are not familiar or comfortable using intravenous iron products to treat functional iron deficiency associated with CRA. This article summarizes our approach to treating CRA and discusses commonly encountered clinical scenarios for which current clinical guidelines do not apply.
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Even if tumor tissue would be optimally vascularized, systemic hypoxia could lead to tumor tissue hypoxia in cancer patients.
“Even if tumor tissue would be optimally vascularized, systemic hypoxia could also lead to tumor tissue hypoxia in cancer patients.”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [33]
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Hypoxia Signaling in Cancer: From Basics to Clinical Practice
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- Authors
- Gilreath, J. A., Stenehjem, D. D., & Rodgers, G. M.
- Affiliations
- Huntsman Cancer Institute (US)
- University of Utah (US)
- University of Utah Hospital (US)
- Corresponding author
- Rodgers, George M.
- Venue
- American Journal of Hematology
- Publisher
- Wiley
- Published
- 2014-02
- Volume
- 89
- Issue
- 2
- Pages
- 203-212
- ISSN
- 0361-8609 (ISSN-L)
- 1096-8652
- OpenAlex
- W1507600704
- Cited by
- 242
- References
- 98
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 26 · 2023: 23 · 2022: 28 · 2021: 25 · 2020: 20 · 2019: 20 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 11 · 2014: 7
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hematology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Society of Clinical Oncology
- Huntsman Cancer Institute
- National Comprehensive Cancer Network
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Keywords
- cancer-related anemia, chemotherapy-induced myelosuppression, functional iron deficiency, erythropoietin deficiency, kidney disease, erythropoiesis-stimulating agents, intravenous iron, red blood cell transfusion
- MeSH terms
- Anemia, Erythropoietin, Humans, Iron, Neoplasms, Prevalence, Treatment Outcome, Erythrocyte Transfusion, Malnutrition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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