The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166 · see citing works

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · see citing works

Two to tango: Regulation of Mammalian iron metabolism

Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120 · see citing works

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385 · see citing works

Hepcidin and iron homeostasis

Ganz, T., & Nemeth, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.014 · Cited by 1,282 · see citing works

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275 · see citing works

Genetic Evidence for High-Altitude Adaptation in Tibet

Simonson, T. S., Yang, Y., Huff, C. D., Yun, H., Qin, G., Witherspoon, D. J., Bai, Z., Lorenzo, F. R., Xing, J., Jorde, L. B., et al. (2010) · Science · doi:10.1126/science.1189406 · Cited by 1,227 · see citing works

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works

An iron-regulated ferric reductase associated with the absorption of dietary iron

McKie, A. T., Barrow, D., Latunde-Dada, G. O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., et al. (2001) · Science · doi:10.1126/science.1057206 · Cited by 1,101 · see citing works

Integration of Oxygen Signaling at the Consensus HRE

Wenger, R. H., Stiehl, D. P., & Camenisch, G. (2005) · Science's STKE · doi:10.1126/stke.3062005re12 · Cited by 1,032 · see citing works

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854 · see citing works

Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M. H., & Goldman, I. D. (2006) · Cell · doi:10.1016/j.cell.2006.09.041 · Cited by 847 · see citing works

Natural selection on <i>EPAS1</i> ( <i>HIF2α</i> ) associated with low hemoglobin concentration in Tibetan highlanders

Beall, C. M., Cavalleri, G. L., Deng, L., Elston, R. C., Gao, Y., Knight, J., Li, C., Li, J. C., Liang, Y., McCormack, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002443107 · Cited by 845 · see citing works

Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs

Wiesener, M. S., Jürgensen, J. S., Rosenberger, C., Scholze, C. K., Hörstrup, J. H., Warnecke, C., Mandriota, S. J., Bechmann, I., Frei, U. A., Pugh, C. W., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0445fje · Cited by 741 · see citing works

Forging a field: the golden age of iron biology.

Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38499 · Cited by 502 · see citing works

Mammalian iron metabolism and its control by iron regulatory proteins

Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.010 · Cited by 493 · see citing works

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

Shah, Y. M., Matsubara, T., Ito, S., Yim, S.-H., & Gonzalez, F. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.012 · Cited by 431 · see citing works

Control of iron homeostasis by an iron-regulated ubiquitin ligase

Vashisht, A. A., Zumbrennen, K. B., Huang, X., Powers, D. N., Durazo, A., Sun, D., Bhaskaran, N., Persson, A., Uhlen, M., Sangfelt, O., et al. (2009) · Science · doi:10.1126/science.1176333 · Cited by 429 · see citing works

Identification of a Human Heme Exporter that Is Essential for Erythropoiesis

Quigley, J. G., Yang, Z., Worthington, M., Phillips, J. D., Sabo, K. M., Sabath, D. E., Berg, C. L., Sassa, S., Wood, B. L., & Abkowitz, J. L. (2004) · Cell · doi:10.1016/j.cell.2004.08.014 · Cited by 423 · see citing works

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

Gunshin, H., Fujiwara, Y., Custodio, A. O., DiRenzo, C., Robine, S., & Andrews, N. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24356 · Cited by 419 · see citing works

pH control mechanisms of tumor survival and growth

Parks, S. K., Chiche, J., & Pouysségur, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22400 · Cited by 356 · see citing works

The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0419 · Cited by 355 · see citing works

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

Frazer, D. M., Wilkins, S. J., Becker, E., Vulpe, C. D., McKie, A. T., Trinder, D., & Anderson, G. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35353 · Cited by 342 · see citing works

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338 · see citing works

Iron metabolism in the anemia of chronic disease

Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322 · see citing works

Hypoxia and gastrointestinal disease

Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313 · see citing works

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Rivera, S., Nemeth, E., Gabayan, V., Lopez, M. A., Farshidi, D., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2005-04-1766 · Cited by 308 · see citing works

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Gardenghi, S., Marongiu, M. F., Ramos, P., Guy, E. C., Breda, L., Chadburn, A., Liu, Y.-F., Amariglio, N., Rechavi, G., Rachmilewitz, E. A., et al. (2007) · Blood · doi:10.1182/blood-2006-09-048868 · Cited by 307 · see citing works

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

Kapitsinou, P. P., Liu, Q., Unger, T. L., Rha, J., Davidoff, O., Keith, B., Epstein, J. A., Moores, S. L., Erickson-Miller, C. L., & Haase, V. H. (2010) · Blood · doi:10.1182/blood-2010-02-270322 · Cited by 307 · see citing works

The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

Dayan, F., Roux, D., Brahimi-Horn, M. C., Pouyssegur, J., & Mazure, N. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4564 · Cited by 294 · see citing works

Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency

Sanchez, M., Galy, B., Muckenthaler, M. U., & Hentze, M. W. (2007) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb1222 · Cited by 294 · see citing works

A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression

Zhang, D.-L., Hughes, R. M., Ollivierre-Wilson, H., Ghosh, M. C., & Rouault, T. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.006 · Cited by 281 · see citing works

P HYSIOLOGY AND M OLECULAR B IOLOGY OF D IETARY I RON A BSORPTION

Miret, S., Simpson, R. J., & McKie, A. T. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073139 · Cited by 269 · see citing works

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

Taylor, M., Qu, A., Anderson, E. R., Matsubara, T., Martin, A., Gonzalez, F. J., & Shah, Y. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.007 · Cited by 265 · see citing works

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

Lesbordes-Brion, J.-C., Viatte, L., Bennoun, M., Lou, D.-Q., Ramey, G., Houbron, C., Hamard, G., Kahn, A., & Vaulont, S. (2006) · Blood · doi:10.1182/blood-2006-02-003376 · Cited by 257 · see citing works

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

White, C., Yuan, X., Schmidt, P. J., Bresciani, E., Samuel, T. K., Campagna, D. R., Hall, C., Bishop, K. S., Calicchio, M. L., Lapierre, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.005 · Cited by 237 · see citing works

The molecular basis of ferroportin-linked hemochromatosis

De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503804102 · Cited by 230 · see citing works

Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation

Brasse–Lagnel, C., Karim, Z., Letteron, P., Bekri, S., Bado, A., & Beaumont, C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.037 · Cited by 230 · see citing works

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 222 · see citing works

Pathways of Iron Absorption

Conrad, M. E., & Umbreit, J. N. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0564 · Cited by 219 · see citing works

Role of the hypoxia inducible factors HIF in iron metabolism

Peyssonnaux, C., Nizet, V., & Johnson, R. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5145 · Cited by 217 · see citing works

Genes that modify the hemochromatosis phenotype in mice

Levy, J. E., Montross, L. K., & Andrews, N. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9635 · Cited by 212 · see citing works

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

Anderson, S. A., Nizzi, C. P., Chang, Y.-I., Deck, K. M., Schmidt, P. J., Galy, B., Damnernsawad, A., Broman, A. T., Kendziorski, C., Hentze, M. W., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.007 · Cited by 211 · see citing works

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

Ginzburg, Y., & Rivella, S. (2011) · Blood · doi:10.1182/blood-2011-03-283614 · Cited by 201 · see citing works

Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2004-08-3375 · Cited by 196 · see citing works

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H.-J., & Hentze, M. W. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.006 · Cited by 195 · see citing works

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

Zimmer, M., Ebert, B. L., Neil, C., Brenner, K., Papaioannou, I., Melas, A., Tolliday, N., Lamb, J., Pantopoulos, K., Golub, T., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.004 · Cited by 191 · see citing works

A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption

Frazer, D. M. (2003) · Gut · doi:10.1136/gut.52.3.340 · Cited by 189 · see citing works

Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice

Gunshin, H., Starr, C. N., DiRenzo, C., Fleming, M. D., Jin, J., Greer, E. L., Sellers, V. M., Galica, S. M., & Andrews, N. C. (2005) · Blood · doi:10.1182/blood-2005-02-0716 · Cited by 188 · see citing works

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

Ghosh, M. C., Zhang, D.-L., Jeong, S. Y., Kovtunovych, G., Ollivierre-Wilson, H., Noguchi, A., Tu, T., Senecal, T., Robinson, G., Crooks, D. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.016 · Cited by 183 · see citing works

Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation

Roy, C. N., Mak, H. H., Akpan, I., Losyev, G., Zurakowski, D., & Andrews, N. C. (2007) · Blood · doi:10.1182/blood-2006-10-051755 · Cited by 178 · see citing works

Hepcidin inhibits apical iron uptake in intestinal cells

Mena, N. P., Esparza, A., Tapia, V., Valdés, P., & Núñez, M. T. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00122.2007 · Cited by 175 · see citing works

The Polycythemia of High Altitudes: Iron Metabolism and Related Aspects

REYNAFARJE, C., Lozano, R., & Valdivieso, J. (1959) · Blood · doi:10.1182/blood.v14.4.433.433 · Cited by 172 · see citing works

Steap Proteins: Implications for Iron and Copper Metabolism

Knutson, M. D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00311.x · Cited by 165 · see citing works

Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project

Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299859 · Cited by 151 · see citing works

Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells

Chaston, T., Chung, B., Mascarenhas, M., Marks, J., Patel, B., Srai, S. K., & Sharp, P. (2008) · Gut · doi:10.1136/gut.2007.131722 · Cited by 145 · see citing works

Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)

Iolascon, A., D’Apolito, M., Servedio, V., Cimmino, F., Piga, A. G., & Camaschella, C. (2005) · Blood · doi:10.1182/blood-2005-06-2477 · Cited by 143 · see citing works

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

Foot, N. J., Dalton, H. E., Shearwin-Whyatt, L. M., Dorstyn, L., Tan, S.-S., Yang, B., & Kumar, S. (2008) · Blood · doi:10.1182/blood-2008-04-150953 · Cited by 143 · see citing works

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

Vanoaica, L., Darshan, D., Richman, L., Schümann, K., & Kühn, L. C. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.003 · Cited by 137 · see citing works

Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice

Viatte, L., Lesbordes, J.-C., Lou, D.-Q., Bennoun, M., Nicolas, G., Kahn, A., Canonne‐Hergaux, F., & Vaulont, S. (2005) · Blood · doi:10.1182/blood-2004-12-4608 · Cited by 119 · see citing works

Tumour necrosis factor α causes hypoferraemia and reduced intestinal iron absorption in mice

Laftah, A. H., Sharma, N., Brookes, M., McKie, A. T., Simpson, R. J., Iqbal, T. H., & Tselepis, C. (2006) · Biochemical Journal · doi:10.1042/bj20060215 · Cited by 114 · see citing works

Effect of Altitude on Erythropoiesis

Faura, J., RAMOS, J., REYNAFARJE, C., English, E., Finne, P. H., & Finch, C. A. (1969) · Blood · doi:10.1182/blood.v33.5.668.668 · Cited by 114 · see citing works

Decreased Hephaestin Activity in the Intestine of Copper-Deficient Mice Causes Systemic Iron Deficiency

Chen, H., Huang, G., Su, T., Gao, H., Attieh, Z. K., McKie, A. T., Anderson, G. J., & Vulpe, C. D. (2006) · Journal of Nutrition · doi:10.1093/jn/136.5.1236 · Cited by 109 · see citing works

Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1

Zoller, H., Theurl, I., Koch, R., Kaser, A., & Weiss, G. (2002) · Blood Cells, Molecules, and Diseases · doi:10.1006/bcmd.2002.0587 · Cited by 106 · see citing works

Iron regulatory proteins control a mucosal block to intestinal iron absorption

Galy, B., Ferring-Appel, D., Becker, C., Gretz, N., Gröne, H.-J., Schümann, K., & Hentze, M. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.026 · Cited by 98 · see citing works

Intestinal Iron Absorption: Regulation by Dietary & Systemic Factors

Sharp, P. (2010) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000029 · Cited by 95 · see citing works

Regulation of hepcidin expression at high altitude

Talbot, N. P., Lakhal, S., Smith, T. G., Privat, C., Nickol, A. H., Rivera-Ch, M., León-Velarde, F., Dorrington, K. L., Mole, D. R., & Robbins, P. A. (2012) · Blood · doi:10.1182/blood-2011-03-341776 · Cited by 93 · see citing works

The Molecular Pathogenesis of Hereditary Hemochromatosis

Babitt, J. L., & Lin, H. Y.-F. (2011) · Seminars in Liver Disease · doi:10.1055/s-0031-1286059 · Cited by 89 · see citing works

Regulation of systemic iron homeostasis: how the body responds to changes in iron demand

Anderson, G. J., Darshan, D., Wilkins, S. J., & Frazer, D. M. (2007) · BioMetals · doi:10.1007/s10534-006-9030-2 · Cited by 86 · see citing works

Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium

Yeh, K., YEH, M. K. Y., Mims, L., & Glass, J. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90298.2008 · Cited by 84 · see citing works

Heme and non-heme iron transporters in non-polarized and polarized cells

Yanatori, I., Tabuchi, M., Kawai, Y., Yasui, Y., Akagi, R., & Kishi, F. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-39 · Cited by 83 · see citing works

In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse

Raja, K. B., Simpson, R. J., Pippard, M. J., & Peters, T. J. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb04217.x · Cited by 72 · see citing works

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

Váchal, P., Miao, S., Pierce, J. M., Guiadeen, D., Colandrea, V. J., Wyvratt, M. J., Salowe, S. P., Sonatore, L. M., Milligan, J. A., Hajdu, R., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201542d · Cited by 67 · see citing works

Iron Regulatory Protein 1 Outcompetes Iron Regulatory Protein 2 in Regulating Cellular Iron Homeostasis in Response to Nitric Oxide

Styś, A., Galy, B., Starzyński, R. R., Smuda, E., Drapier, J., Lipiński, P., & Bouton, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.231902 · Cited by 65 · see citing works

A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis

Constantine, C. C., Anderson, G. J., Vulpe, C. D., McLaren, C. E., Bahlo, M., Yeap, H. L., Gertig, D. M., Osborne, N. J., Bertalli, N. A., Beckman, K. B., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07843.x · Cited by 64 · see citing works

Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression

Leung, P. S. (2005) · Gut · doi:10.1136/gut.2004.062083 · Cited by 62 · see citing works

Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2α and Altered Expression of Iron Absorption Genes in Mice

Matak, P., Zumerle, S., Mastrogiannaki, M., Balkhi, S. E., Delga, S., Mathieu, J. R. R., Canonne‐Hergaux, F., Poupon, J., Sharp, P., Vaulont, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059538 · Cited by 62 · see citing works

Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells

Johnson, D., Bayele, H. K., Johnston, K. L., Tennant, J. P., Srai, S. K., & Sharp, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.081 · Cited by 60 · see citing works

Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions3

Choi, J., Masaratana, P., Latunde-Dada, G. O., Arno, M. J., Simpson, R. J., & McKie, A. T. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160358 · Cited by 60 · see citing works

Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis

Anderson, E. R., Xue, X., & Shah, Y. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238667 · Cited by 57 · see citing works

Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

Mastrogiannaki, M., Matak, P., Delga, S., Deschemin, J.-C., Vaulont, S., & Peyssonnaux, C. (2012) · Blood · doi:10.1182/blood-2011-09-380337 · Cited by 57 · see citing works

Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism

Ferring–Appel, D., Hentze, M. W., & Galy, B. (2008) · Blood · doi:10.1182/blood-2008-05-155093 · Cited by 53 · see citing works

Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis

Latunde-Dada, G. O., Vulpe, C. D., Anderson, G. J., Simpson, R. J., & McKie, A. T. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.011 · Cited by 50 · see citing works

Not all DMT1 mutations lead to iron overload

Blanco, E., Kannengiesser, C., Grandchamp, B., Tasso, M., & Beaumont, C. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.05.003 · Cited by 48 · see citing works

Animal Models of Anemia of Inflammation

Rivera, S., & Ganz, T. (2009) · Seminars in Hematology · doi:10.1053/j.seminhematol.2009.06.003 · Cited by 48 · see citing works

Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure

Srai, S. K., Chung, B., Marks, J., Pourvali, K., Solanky, N., Rapisarda, C., Chaston, T. B., Hanif, R., Unwin, R. J., Debnam, E. S., et al. (2010) · Kidney International · doi:10.1038/ki.2010.217 · Cited by 43 · see citing works

Dietary Iron Levels and Hypoxia Independently affect Iron Absorption in Mice

Simpson, R. J. (1996) · Journal of Nutrition · doi:10.1093/jn/126.7.1858 · Cited by 37 · see citing works

Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.

Recalcati, S., Alberghini, A., Campanella, A., Gianelli, U., Camilli, E. D., Conte, D., & Cairo, G. (2006) · PubMed · Cited by 34 · see citing works

The Influence of Hypoxia on Iron Absorption in the Rat

Hathorn, M. K. S. (1971) · Gastroenterology · doi:10.1016/s0016-5085(71)80009-4 · Cited by 32 · see citing works

Hypoxia Inducible Factor-2a Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats

Davis, M. R., Shawron, K., Rendina-Ruedy, E., Peterson, S., Lucas, E. A., Smith, B. J., & Clarke, S. L. (2011) · Journal of Nutrition · doi:10.3945/jn.111.144105 · Cited by 30 · see citing works

Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved

Luo, Q., Wang, D., Yu, M., & Zhu, L. (2011) · IUBMB Life · doi:10.1002/iub.419 · Cited by 22 · see citing works

Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase

Denny, W. A. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300314a · Cited by 12 · see citing works

Hypoferraemia during the early inflammatory response is dependent on tumour necrosis factor activity in a murine model of protracted peritonitis

Schubert, T. E. O., Bosserhoff, A., Peyssonnaux, C., Echtenacher, B., Knutson, M. D., Hofstädter, F., & Männel, D. N. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1004 · Cited by 7 · see citing works

Lack of iron-related phenotype in Sp6 intestinal knockout mice

Matak, P., Deschemin, J., Peyssonnaux, C., & Vaulont, S. (2011) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.03.009 · Cited by 3 · see citing works

Iron-Deficiency Anemia

Camaschella, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1401038 · Cited by 1,678 · see citing works

Iron metabolism and iron disorders revisited in the hepcidin era

Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734 · see citing works

Iron deficiency

Camaschella, C. (2019) · Blood · doi:10.1182/blood-2018-05-815944 · Cited by 702 · see citing works

Oral Iron Supplements Increase Hepcidin and Decrease Iron Absorption from Daily or Twice-Daily Doses in Iron-Depleted Young Women

Moretti, D., Goede, J. S., Zeder, C., Jiskra, M., Chatzinakou, V., Tjalsma, H., Melse-Boonstra, A., Brittenham, G., Swinkels, D. W., & Zimmermann, M. B. (2015) · Blood · doi:10.1182/blood-2015-05-642223 · Cited by 547 · see citing works

Iron deficiency anaemia revisited

Cappellini, M. D., Musallam, K. M., & Taher, A. T. (2019) · Journal of Internal Medicine · doi:10.1111/joim.13004 · Cited by 558 · see citing works

Oxygen availability and metabolic adaptations

Nakazawa, M. S., Keith, B., & Simon, M. C. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.84 · Cited by 431 · see citing works

The IRP/IRE system in vivo: insights from mouse models

Wilkinson, N., & Pantopoulos, K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00176 · Cited by 366 · see citing works

New insights into iron deficiency and iron deficiency anemia

Camaschella, C. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.02.004 · Cited by 278 · see citing works

Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245 · see citing works

Diagnosis and Treatment of Cancer-Related Anemia

Gilreath, J. A., Stenehjem, D. D., & Rodgers, G. M. (2014) · American Journal of Hematology · doi:10.1002/ajh.23628 · Cited by 242 · see citing works

The regulation of iron transport

Frazer, D. M., & Anderson, G. J. (2013) · BioFactors · doi:10.1002/biof.1148 · Cited by 215 · see citing works

Iron deficiency: new insights into diagnosis and treatment

Camaschella, C. (2015) · Hematology · doi:10.1182/asheducation-2015.1.8 · Cited by 201 · see citing works

Oral iron supplementation in iron-deficient women: How much and how often?

Stoffel, N. U., von Siebenthal, H. K., Moretti, D., & Zimmermann, M. B. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100865 · Cited by 205 · see citing works

Management of iron deficiency

Ning, S., & Zeller, M. P. (2019) · Hematology · doi:10.1182/hematology.2019000034 · Cited by 163 · see citing works

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

Morris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 154 · see citing works

Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

Lane, D. J. R., Bae, D.-H., Merlot, A. M., Sahni, S., & Richardson, D. R. (2015) · Nutrients · doi:10.3390/nu7042274 · Cited by 153 · see citing works

Adaptation to High Altitude: Phenotypes and Genotypes

Beall, C. M. (2014) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102313-030000 · Cited by 147 · see citing works

Intestinal Iron Absorption

McKie, A. T., & Simpson, R. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_6 · Cited by 132 · see citing works

-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

Rivella, S. (2015) · Haematologica · doi:10.3324/haematol.2014.114827 · Cited by 122 · see citing works

An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia-inducible factors (HIFs)

Hirota, K. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.018 · Cited by 106 · see citing works

Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism

Rychtarcikova, Z., Lettlova, S., Tomkova, V., Korenkova, V., Langerova, L., Simonova, E., Zjablovskaja, P., Alberich-Jorda, M., Neuzil, J., & Truksa, J. (2017) · Oncotarget · doi:10.18632/oncotarget.14093 · Cited by 100 · see citing works

Anemia of Chronic Diseases: Wider Diagnostics—Better Treatment?

Wiciński, M., Liczner, G., Cadelski, K., Kołnierzak, T., Nowaczewska, M., & Malinowski, B. (2020) · Nutrients · doi:10.3390/nu12061784 · Cited by 113 · see citing works

The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review

Malesza, I. J., Bartkowiak-Wieczorek, J., Winkler-Galicki, J., Nowicka, A., Dzięciołowska, D., Błaszczyk, M., Gajniak, P., Słowińska, K., Niepolski, L., Walkowiak, J., et al. (2022) · Nutrients · doi:10.3390/nu14173478 · Cited by 109 · see citing works

Dietary iron intake, iron status, and gestational diabetes

Zhang, C., & Rawal, S. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156034 · Cited by 100 · see citing works

Role of Intestinal HIF-2α in Health and Disease

Ramakrishnan, S. K., & Shah, Y. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105202 · Cited by 98 · see citing works

Hypoxia-inducible transcription factors in fish: expression, function and interconnection with the circadian clock

Pelster, B., & Egg, M. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.163709 · Cited by 86 · see citing works

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Szudzik, M., Starzyński, R. R., Jończy, A., Mazgaj, R., Lenartowicz, M., & Lipiński, P. (2018) · Pharmaceuticals · doi:10.3390/ph11040128 · Cited by 83 · see citing works

The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients

Zumbrennen‐Bullough, K. B., & Babitt, J. L. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft443 · Cited by 80 · see citing works

Therapeutic potential of hepcidin − the master regulator of iron metabolism

Vyoral, D., & Petrák, J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.010 · Cited by 79 · see citing works

Iron Deficiency and Iron Deficiency Anemia: A Comprehensive Overview of Established and Emerging Concepts

Kolarš, B., Mijatović Jovin, V., Živanović, N., Minaković, I., Gvozdenović, N., Dickov Kokeza, I., & Lesjak, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081104 · Cited by 71 · see citing works

ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma

Green, Y. S., Ferreira dos Santos, M. C., Fuja, D. G., Reichert, E. C., Campos, A. R., Cowman, S. J., Acuña Pilarte, K., Kohan, J., Tripp, S. R., Leibold, E. A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02460-1 · Cited by 69 · see citing works

Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury

Zhang, J., Han, C., Dai, H., Hou, J., Dong, Y., Cui, X., Xu, L., Zhang, M., & Xia, Q. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014121248 · Cited by 63 · see citing works

Intracellular iron and heme trafficking and metabolism in developing erythroblasts

Kafina, M. D., & Paw, B. H. (2017) · Metallomics · doi:10.1039/c7mt00103g · Cited by 62 · see citing works

2017 Clinical trials update in new treatments of β‐thalassemia

Makis, A. C., Hatzimichael, E. C., Papassotiriou, I., & Voskaridou, E. (2016) · American Journal of Hematology · doi:10.1002/ajh.24530 · Cited by 58 · see citing works

Hypoxia-inducible factor (HIF): The link between obesity and COVID-19

AbdelMassih, A. F., Yacoub, E., Husseiny, R., Kamel, A., Hozaien, R., Shershaby, M. E., Rajab, M., Yacoub, S., Eid, M. A., ElAhmady, M., et al. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100317 · Cited by 51 · see citing works

Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways

Dvornikova, K. A., Platonova, O. N., & Bystrova, E. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032425 · Cited by 51 · see citing works

Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities

Abbasi, U., Abbina, S., Gill, A., Takuechi, L. E., & Kizhakkedathu, J. N. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00122 · Cited by 47 · see citing works

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease

Das, N. K., Xie, L., Ramakrishnan, S. K., Campbell, A., Rivella, S., & Shah, Y. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.c115.681643 · Cited by 46 · see citing works

Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms

Enculescu, M., Metzendorf, C., Sparla, R., Hahnel, M. J., Bode, J. G., Muckenthaler, M. U., & Legewie, S. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005322 · Cited by 45 · see citing works

The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia

Landau, D., London, L., Bandach, I., & Segev, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196684 · Cited by 43 · see citing works

Compared with Daily, Weekly n–3 PUFA Intake Affects the Incorporation of Eicosapentaenoic Acid and Docosahexaenoic Acid into Platelets and Mononuclear Cells in Humans

Browning, L. M., Walker, C. G., Mander, A., West, A. L., Gambell, J., Madden, J., Calder, P. C., & Jebb, S. A. (2014) · Journal of Nutrition · doi:10.3945/jn.113.186346 · Cited by 40 · see citing works

Advances in understanding iron metabolism and its crosstalk with erythropoiesis

Camaschella, C., & Pagani, A. (2018) · British Journal of Haematology · doi:10.1111/bjh.15403 · Cited by 40 · see citing works

A Novel Choice to Correct Inflammation-Induced Anemia in CKD: Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat

Yan, Z., & Xu, G. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00393 · Cited by 40 · see citing works

Hypoxia-Inducible Factor–Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Noninferiority Compared with Current ESAs?

Locatelli, F., & Vecchio, L. D. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022040413 · Cited by 40 · see citing works

EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Zhang, J., Shen, Y., Liu, C., Yang, J., Yang, Y., Zhang, C., Bian, S., Yu, J., Gao, X., Zhang, L.-P., et al. (2020) · Military Medical Research · doi:10.1186/s40779-020-00264-6 · Cited by 38 · see citing works

Study of the coordination of ortho-tyrosine and trans-4-hydroxyproline with aluminum(III) and iron(III)

Aiello, D., Furia, E., Siciliano, C., Bongiorno, D., & Napoli, A. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.08.074 · Cited by 36 · see citing works

Chronic Myeloid Leukemia - Prognostic Value of Mutations

Kaleem, B., Shahab, S., Ahmed, N., & Shamsi, T. S. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.17.7415 · Cited by 32 · see citing works

An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin

Moretti, D., Mettler, S., Zeder, C., Lundby, C., Geurts-Moespot, A. J., Monnard, A., Swinkels, D. W., Brittenham, G. M., & Zimmermann, M. B. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy247 · Cited by 30 · see citing works

Mechanisms and Regulation of Intestinal Iron Transport

Collins, J. F., Flores, S. R., Wang, X., & Anderson, G. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00060-8 · Cited by 30 · see citing works

Iron and Chronic Kidney Disease: Still a Challenge

Wojtaszek, E., Głogowski, T., & Małyszko, J. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.565135 · Cited by 29 · see citing works

The interplay between iron and oxygen homeostasis with a particular focus on the heart

Lakhal‐Littleton, S., & Robbins, P. A. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00237.2017 · Cited by 29 · see citing works

Iron Metabolism, Iron Deficiency and Disorders of Haem Synthesis

Camaschella, C., Hoffbrand, A. V., & Hershko, C. (2015) · doi:10.1002/9781118853771.ch3 · Cited by 29 · see citing works

Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply

Mazgaj, R., Lipiński, P., Edison, E. S., Bednarz, A., Staroń, R., Haberkiewicz, O., Lenartowicz, M., Smuda, E., Jończy, A., & Starzyński, R. R. (2021) · American Journal of Hematology · doi:10.1002/ajh.26152 · Cited by 27 · see citing works

Roxadustat alleviates the inflammatory status in patients receiving maintenance hemodialysis with erythropoiesis-stimulating agent resistance by increasing the short-chain fatty acids producing gut bacteria

Zhao, X.-N., Liu, S., Wang, Z., Zhang, S., & You, L.-L. (2023) · European journal of medical research · doi:10.1186/s40001-023-01179-3 · Cited by 23 · see citing works

Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice

Ramakrishnan, S. K., Anderson, E. R., Martin, A. S., Centofanti, B., & Shah, Y. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504891112 · Cited by 23 · see citing works

Is Body Mass Index a potential biomarker for anemia in obese adolescents?

Pande, S., Ranjan, R., & Kratasyuk, V. A. (2018) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2018.11.001 · Cited by 20 · see citing works

Iron and Vitamin D/Calcium Deficiency after Gastric Bypass: Mechanisms Involved and Strategies to Improve Oral Supplement Disposition

Mangan, A., le Roux, C. W., Gletsu-Miller, N. A., & Docherty, N. G. (2018) · Current Drug Metabolism · doi:10.2174/1389200219666181026160242 · Cited by 20 · see citing works

Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia

Ohno, Y., Hanawa, H., Jiao, S., Hayashi, Y., Yoshida, K., Suzuki, T., Kashimura, T., Obata, H., Tanaka, K., Watanabe, T., et al. (2015) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.235.69 · Cited by 19 · see citing works

Iron-Deficiency Anemia

Besarab, A., & Hemmerich, S. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7360-6_2 · Cited by 19 · see citing works

Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats

Cao, C. Q., Thomas, C. E., Insogna, K. L., & O'Brien, K. O. (2014) · Journal of Nutrition · doi:10.3945/jn.114.197939 · Cited by 17 · see citing works

The use of hypotransferrinemic mice in studies of iron biology

Bu, J. T., & Bartnikas, T. B. (2015) · BioMetals · doi:10.1007/s10534-015-9833-0 · Cited by 16 · see citing works

Interpreting Iron Homeostasis in Congenital and Acquired Disorders

Scaramellini, N., Fischer, D. P., Agarvas, A. R., Motta, I., Muckenthaler, M. U., & Mertens, C. (2023) · Pharmaceuticals · doi:10.3390/ph16030329 · Cited by 14 · see citing works

Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects

Yang, X., Wang, X., Yang, Z., & Lu, H. (2025) · Current Obesity Reports · doi:10.1007/s13679-024-00600-0 · Cited by 14 · see citing works

Human Gut Microbiota in Heart Failure: Trying to Unmask an Emerging Organ

PARASKEVAIDIS, I. A., Xanthopoulos, A. V., Tsougos, E., & Triposkiadis, F. K. (2023) · Biomedicines · doi:10.3390/biomedicines11092574 · Cited by 13 · see citing works

Alcohol exposure increases manganese accumulation in the brain and exacerbates manganese-induced neurotoxicity in mice

Han, M., Böhlke, M., Maher, T. J., & Kim, J. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03166-1 · Cited by 13 · see citing works

Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects

Wang, J., Zhao, B., Che, J., & Shang, P. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043129 · Cited by 13 · see citing works

Advances in understanding the crosstalk between mother and fetus on iron utilization

Lakhal‐Littleton, S. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.06.003 · Cited by 15 · see citing works

Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells

Scheers, N., Pereira, D. I. A., Faria, N., & Powell, J. J. (2018) · Oncotarget · doi:10.18632/oncotarget.24899 · Cited by 13 · see citing works

Metabolism of Iron and Heme

Bhagavan, N. V., & Ha, C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-416687-5.00027-0 · Cited by 12 · see citing works

Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease

Varghese, J., Varghese, J., Karthikeyan, M., Rasalkar, K., Raghavan, R., Sukumaran, A., Premkumar, P. S., Eapen, C., & Jacob, M. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.126442 · Cited by 11 · see citing works

Current iron therapy in the light of regulation, intestinal microbiome, and toxicity: are we prescribing too much iron?

Dentand, A., Schubert, M. G., & Krayenbuehl, P. (2024) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2024.2331477 · Cited by 18 · see citing works

Role of Iron Metabolism-Related Genes in Prenatal Development: Insights from Mouse Transgenic Models

Kopeć, Z., Starzyński, R. R., Jończy, A., Mazgaj, R., & Lipiński, P. (2021) · Genes · doi:10.3390/genes12091382 · Cited by 10 · see citing works

Beneficial effect of roxadustat on early posttransplant anemia and iron utilization in kidney transplant recipients: a retrospective comparative cohort study

Li, H., Hu, S.-M., Li, Y., Ciancio, G., Tadros, N. N., Tao, Y., Bai, Y.-J., & Shi, Y. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5897 · Cited by 11 · see citing works

The interplay mechanisms between gut microbiota and ferroptosis in inflammatory bowel disease

Shi, Z., Zhang, S., Zhai, H., Wu, Q., Li, Y., Xu, H., & Zhang, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1753617 · Cited by 9 · see citing works

Dietary Iron Absorption: Biochemical and Nutritional Aspects

Frazer, D. M., Anderson, G. J., & Collins, J. F. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-92033-2_6 · Cited by 8 · see citing works

Mimicking Gene–Environment Interaction of Higher Altitude Dwellers by Intermittent Hypoxia Training: COVID-19 Preventive Strategies

Supriya, R., Singh, K. P., Gao, Y., Tao, D., Cheour, S., Dutheil, F., & Baker, J. S. (2022) · Biology · doi:10.3390/biology12010006 · Cited by 8 · see citing works

Heme metabolism as an integral part of iron homeostasis

Lipiński, P., Starzyński, R. R., Styś, A., Gajowiak, A., & Staroń, R. (2014) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1102284 · Cited by 8 · see citing works

HIF2α, Hepcidin and their crosstalk as tumour-promoting signalling

Formica, V., Riondino, S., Morelli, C., Guerriero, S., D’Amore, F., Grazia, A. D., Blanco, G. D. V., Sica, G. S., Arkenau, H., Monteleone, G., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02266-2 · Cited by 7 · see citing works

Iron regulatory protein 1 is required for the propagation of inflammation in inflammatory bowel disease

Fahoum, L., Moshe-Belizowski, S., Zaydel, K., Ghatpande, N., Guttmann‐Raviv, N., Zhang, W., Li, K.-Y., Tong, W.-H., Nyska, A., Waterman, M., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107639 · Cited by 7 · see citing works

Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Borkowska, A., Tomczyk, M., Żychowska, M., Pilis, W., Zych, M., & Antosiewicz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063248 · Cited by 7 · see citing works

Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human

Liu, W., Wu, Y. X., Zhang, N., Liu, S., & Zhou, L. (2022) · Disease Markers · doi:10.1155/2022/1664474 · Cited by 7 · see citing works

Current research on the HIF-2α-EPO–Hb axis in hypoxic environments: from molecular mechanisms to clinical

Zheng, Q., Li, Y., & Li, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1780669 · Cited by 5 · see citing works

Deferasirox exerts anti-epileptic effects by improving brain iron homeostasis via regulation of ITPRIP

Duan, X., Han, H., Liu, J., Qiu, Y. L., Wang, Y., Wu, X., Zhang, H., Zou, Z., Qiu, J., Chen, C., et al. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105725 · Cited by 5 · see citing works

Mendelian inheritance of anemia due to disturbed iron homeostasis

Camaschella, C., & Pagani, A. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.05.003 · Cited by 5 · see citing works

Iron Deficiency Anemia

Mettananda, S., & Athapathu, A. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00028-7 · Cited by 5 · see citing works

Could Hepcidin Be a New Biomarker in Patients with Idiopathic Pulmonary Fibrosis (IPF)?

Yilmaz, G., Çoban, H., Sarıoğlu, N., Erel, F., Yılmaz, M. A., Çolak, M., Şenel, M. Y., & Hişmioğulları, A. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226823 · Cited by 3 · see citing works

Pesticide exposure induces risks of gestational anemia by maternal gut microbiota: A prospective cohort study

Dong, C., Yu, S., Deng, S., Xia, Z., Rigoberto, F. C., Sultan, M., Xu, X., Jin, B., Guan, Q., Sun, Z., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138465 · Cited by 3 · see citing works

The Vicious Circle of Metabolic Dysfunction-Associated Steatotic Liver Disease When Micronutrient Deficiency Drives Microbial Imbalance and Liver Injury

Mărginean, I. C., Cazacu, S. M., Popescu, M., Iacob, G. A., Săndulescu, L., Iordache, S., Mărginean, C. M., & Vere, C. C. (2025) · Life · doi:10.3390/life15111764 · Cited by 3 · see citing works

Iron deficiency anemia in suckling piglets: When physiology cannot keep up with breeding goals

Lipiński, P., Starzyński, R. R., Lenartowicz, M., Wang, X., Ogłuszka, M., & Batorska, M. (2025) · The Veterinary Journal · doi:10.1016/j.tvjl.2025.106530 · Cited by 4 · see citing works

Gum Arabic-Derived Hydroxyproline-Rich Peptides Stimulate Intestinal Nonheme Iron Absorption via HIF2α-Dependent Upregulation of Iron Transport Proteins

Li, S., Xing, W., Gang, Y., Zhang, M., Zhao, Z., Wu, H., & Zhu, S. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09588 · Cited by 3 · see citing works

Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and efflux in enterocytes

Julián Herrera, M., Parra-Sosa, B. E., Vanessa Corrales, A., Manuel Olivares, G., Fernando Pizarro, A., & Gaitán, D. (2015) · Revista chilena de nutrición · doi:10.4067/s0717-75182015000400011 · Cited by 3 · see citing works

The Effect of HIF‐2 α on the Development of Inflammation

Huang, J., & Zhao, D. (2025) · International Journal of Inflammation · doi:10.1155/ijin/9092758 · Cited by 2 · see citing works

Croatian Hematology Society and CROHEM guidelines for the treatment of iron deficiency anemia

Radman, I., Vodanović, M., Mandac-Rogulj, I., Roganović, J., Petranović, D., Valković, T., Kolonić, S. O., Pejša, V., Kušec, R., & Aurer, I. (2019) · Liječnički vjesnik · doi:10.26800/lv-141-1-2-1 · Cited by 2 · see citing works

Iron Homeostasis and Inflammatory Status in Mice Deficient for the Cystic Fibrosis Transmembrane Regulator

Deschemin, J., Allouche, S., Brouillard, F., & Vaulont, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145685 · Cited by 2 · see citing works

Regulación del metabolismo del hierro: dos sistemas, un mismo objetivo

Barrios, M. F. (2016) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2 · see citing works

Roles of ghrelin, hepcidin and HIF-2α in iron metabolism in iron deficiency anemia

Güzel, E. R., Sarkaya, N. C., Kurtoğlu, A. U., Karakuş, V., & Kurtoğlu, E. (2024) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-024-03655-z · Cited by 2 · see citing works

Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice

Zhang, F., Zhang, C., Luo, Q., Li, J., Qiu, X., & Qian, Z. (2025) · Redox Report · doi:10.1080/13510002.2025.2602306 · Cited by 1 · see citing works

Ferrotherapy Mistakes in Toddlers in Primary Health Care

Balashova, E. A., & Mazur, L. I. (2015) · Педиатрическая фармакология · doi:10.15690/pf.v12i3.1363 · Cited by 1 · see citing works

IRP2-Hif1α/Hif2α signaling: a novel mechanism of metabolic switch from aerobic glycolysis to oxidative phosphorylation

Zhu, L., Zhou, Q., He, L., & Chen, L. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa088 · Cited by 1 · see citing works

Intestinal ferritinophagy is regulated by HIF-2α and is essential for systemic iron homeostasisPreprint

Das, N. K., Sankar, A. D., Schwartz, A. J., Solanki, S. A., Ma, X., Parimi, S., Santana-Codina, N., Mancias, J. D., & Shah, Y. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.01.364059 · Cited by 1 · see citing works

Role of hepatic and intestinal HIF (Hypoxia Inducible Factors) transcription factors in the regulation of iron homeostasis

Mastrogiannaki, M., Vaulont, S., & Peyssonnaux, C. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)

Regulation of Intestinal Iron Absorption: The Mucosa Takes Control?

Simpson, R. J., & McKie, A. T. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.009 · Cited by 47 · see citing works

The Gut: Role at Steady State and Variations in Disordered Conditions

Peyssonnaux, C. (2012) · Blood · doi:10.1182/blood.v120.21.sci-23.sci-23

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38499 · Cited by 502 · see citing works

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

Schwartz, A. J., Das, N. K., Ramakrishnan, S. K., Jain, C., Jurkovic, M. T., Wu, J., Nemeth, E., Lakhal-Littleton, S., Colacino, J. A., & Shah, Y. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122359 · Cited by 203 · see citing works