Abnormal circadian rhythm of melatonin in Smith–Magenis syndrome patients with RAI1 point mutations
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RAI1 is implicated in melatonin secretion, and inverted melatonin rhythms may be responsible for the sleep disturbances in SMS.
“RAI1 is implicated in melatonin secretion, and inverted melatonin rhythms may be responsible for these sleep disturbances132.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [132]
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Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192 · see citing works
Self-citationBrzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549 · see citing works
Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve
Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works
Interstitial deletion of (17)(p11.2p11.2) in nine patients
Smith, A. C. M., McGavran, L., Robinson, J., Waldstein, G., Macfarlane, J., Zonona, J., Reiss, J. A., Lahr, M. B., Allen, L., Magenis, E., et al. (1986) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320240303 · Cited by 400 · see citing works
Chen, K., Manian, P., Koeuth, T., Potocki, L., Zhao, Q., Chinault, A. C., Lee, C. C., & Lupski, J. R. (1997) · Nature Genetics · doi:10.1038/ng1097-154 · Cited by 387 · see citing works
Self-citationMutations in RAI1 associated with Smith-Magenis syndrome
Slager, R. E., Newton, T. L., Vlangos, C. N., Finucane, B., & Elsea, S. H. (2003) · Nature Genetics · doi:10.1038/ng1126 · Cited by 362 · see citing works
Greenberg, F., Guzzetta, de Oca-Luna, R. M., Magenis, R. E., Smith, A. C., Richter, S. F., Kondo, I., Dobyns, W. B., Patel, P. I., & Lupski (1991) · PubMed · Cited by 340 · see citing works
FALL IN NOCTURNAL SERUM MELATONIN DURING PREPUBERTY AND PUBESCENCE
Waldhauser, F., Frisch, H., Waldhauser, M., Weiszenbacher, G., Zeitlhuber, U., & Wurtman, R. J. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90412-4 · Cited by 303 · see citing works
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome
Potocki, L., Glaze, D., Tan, D.-X., Park, S.-S., Kashork, C. D., Shaffer, L. G., Reiter, R. J., & Lupski, J. R. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.6.428 · Cited by 244 · see citing works
Self-citationInversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome
Leersnyder, H. D., de Blois, M., Claustrat, B., Romana, S. P., Albrecht, U., von Kleist-Retzow, J., Delobel, B., Viot, G., Lyonnet, S., Vekemans, M. J. J., et al. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.115018 · Cited by 198 · see citing works
Gender, genotype, and phenotype differences in Smith–Magenis syndrome: a meta‐analysis of 105 cases
Edelman, E., Girirajan, S., Finucane, B. M., Patel, P. I., Lupski, J., Smith, A., & Elsea, S. H. (2007) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00815.x · Cited by 166 · see citing works
Self-citationNeurologic and Developmental Features of the Smith-Magenis Syndrome (del 17p11.2)
Gropman, A. L., Duncan, W. C., & Smith, A. C. M. (2006) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.08.018 · Cited by 155 · see citing works
Girirajan, S., Vlangos, C. N., Szomju, B. B., Edelman, E. A., Trevors, C. D., Dupuis, L., Nezarati, M. M., Bunyan, D. J., & Elsea, S. H. (2006) · Genetics in Medicine · doi:10.1097/01.gim.0000228215.32110.89 · Cited by 154 · see citing works
Clinical trials of controlled‐release melatonin in children with sleep–wake cycle disorders
Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Fréeman, R. D., & Laudon, M. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.290105.x · Cited by 152 · see citing works
Ricard, G., Molina, J., Chrast, J., Gu, W., Gheldof, N., Pradervand, S., Schütz, F., Young, J. I., Lupski, J. R., Reymond, A., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000543 · Cited by 147 · see citing works
Self-citationLiburd, N., Ghosh, M., Riazuddin, S., Naz, S., Khan, S., Ahmed, Z. M., Riazuddin, S. A., Liang, Y., Menon, P. S. N., Smith, T. N., et al. (2001) · Human Genetics · doi:10.1007/s004390100604 · Cited by 137 · see citing works
Self-citationDe Leersnyder, H., Bresson, J. L., de Blois, M.-C., Souberbielle, J.-C., Mogenet, A., Delhotal-Landes, B., Salefranque, F., & Munnich, A. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.1.74 · Cited by 126 · see citing works
Bi, W., Park, S. S., Shaw, C. J., Withers, M. A., Patel, P. I., & Lupski, J. R. (2003) · The American Journal of Human Genetics · doi:10.1086/379979 · Cited by 122 · see citing works
Self-citationRAI1 variations in Smith–Magenis syndrome patients without 17p11.2 deletions
Girirajan, S., Elsas, L. J., Devriendt, K., & Elsea, S. H. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.031211 · Cited by 122 · see citing works
Efficacy of Melatonin as a Sleep-Promoting Agent
Zhdanova, I. V., & Wurtman, R. J. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200620 · Cited by 115 · see citing works
Potocki, L., Shaw, C. J., Stankiewicz, P., & Lupski, J. R. (2003) · Genetics in Medicine · doi:10.1097/01.gim.0000095625.14160.ab · Cited by 114 · see citing works
Self-citationBi, W., Yan, J., Stankiewicz, P., Park, S. S., Walz, K., Boerkoel, C. F., Potocki, L., Shaffer, L. G., Devriendt, K., Nowaczyk, M. J. M., et al. (2002) · Genome Research · doi:10.1101/gr.73702 · Cited by 114 · see citing works
Self-citationDexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock
Cheng, H. M., Obrietan, K. H., Cain, S. W., Lee, B. Y., Agostino, P. V., Joza, N. A., Harrington, M. E., Ralph, M. R., & Penninger, J. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.021 · Cited by 113 · see citing works
De Leersnyder, H., de Blois, M.-C., Vekemans, M., Sidi, D., Villain, E., Kindermans, C., & Munnich, A. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.9.586 · Cited by 113 · see citing works
Mutations of RAI1, a PHD-containing protein, in nondeletion patients with Smith-Magenis syndrome
Bi, W., Saifi, G. M., Shaw, C. J., Walz, K., Fonseca, P., Wilson, M., Potocki, L., & Lupski, J. R. (2004) · Human Genetics · doi:10.1007/s00439-004-1187-6 · Cited by 110 · see citing works
Self-citationInverted rhythm of melatonin secretion in Smith–Magenis syndrome: from symptoms to treatment
Leersnyder, H. D. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.07.007 · Cited by 98 · see citing works
Genetic Proof of Unequal Meiotic Crossovers in Reciprocal Deletion and Duplication of 17p11.2
Shaw, C. J., Bi, W., & Lupski, J. R. (2002) · The American Journal of Human Genetics · doi:10.1086/344346 · Cited by 98 · see citing works
Self-citationVlangos, C. N. (2003) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(03)00048-9 · Cited by 86 · see citing works
Circadian rhythm disorder in a rare disease: Smith–Magenis syndrome
De Leersnyder, H., Claustrat, B., Munnich, A., & Verloes, A. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.043 · Cited by 56 · see citing works
RAI1 point mutations, CAG repeat variation, and SNP analysis in non‐deletion Smith–Magenis syndrome
Bi, W., Saifi, G. M., Girirajan, S., Shi, X., Szomju, B. B., Firth, H. V., Magenis, R. E., Potocki, L., Elsea, S. H., & Lupski, J. R. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31510 · Cited by 50 · see citing works
Self-citationCarpizo, R., Martínez, Á., Mediavilla, D., González, M., Abad, A., & Sánchez‐Barceló, E. J. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.04.055 · Cited by 44 · see citing works
Twenty‐four hour urinary excretion of 6‐hydroxymelatonin sulfate in Down syndrome subjects
Reiter, R. J., Barlow‐Walden, L., Pöeggeler, B., Heiden, S. M., & Clayton, R. J. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00238.x · Cited by 19 · see citing works
Self-citationZubenko, G. S., Stiffler, J. S., Hughes, H. B., Hurtt, M. R., & Kaplan, B. B. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980328)81:2 · Cited by 18 · see citing works
Further delineation of the acro-renal-ocular syndrome
(1996) · Pure Amsterdam UMC · doi:10.1002/(sici)1096-8628(19960329)62:3 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review
Blackmer, A. B., & Feinstein, J. A. (2016) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1686 · Cited by 237 · see citing works
Williams, S. R., Zies, D., Mullegama, S. V., Grotewiel, M. S., & Elsea, S. H. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.04.013 · Cited by 115 · see citing works
Chen, H., Cade, B. E., Gleason, K. J., Bjonnes, A. C., Stilp, A. M., Sofer, T., Conomos, M. P., Ancoli-Israel, S., Arens, R., Azarbarzin, A., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0237oc · Cited by 82 · see citing works
Neira‐Fresneda, J., & Potocki, L. (2015) · Journal of Pediatric Genetics · doi:10.1055/s-0035-1564443 · Cited by 61 · see citing works
Self-citationRAI1 gene mutations: mechanisms of Smith–Magenis Syndrome
Falco, M., Amabile, S., & Acquaviva, F. (2017) · The Application of Clinical Genetics · doi:10.2147/tacg.s128455 · Cited by 61 · see citing works
Behavioral disturbance and treatment strategies in Smith-Magenis syndrome
Poisson, A., Nicolas, A., Cochat, P., Sanlaville, D., Rigard, C., Leersnyder, H. D., Franco, P., Portes, V. D., Edery, P., & Demily, C. (2015) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-015-0330-x · Cited by 57 · see citing works
Chen, P., Li, S., Zhang, K., Zhao, R., Cui, J., Wei, Z., Liu, Y., Zhang, L., & Cheng, Y. (2021) · Oncogene · doi:10.1038/s41388-021-01966-4 · Cited by 56 · see citing works
Barfield, R., Wang, H., Liu, Y., Brody, J. A., Swenson, B. R., Li, R., Bartz, T. M., Sotoodehnia, N., Chen, Y. I., Cade, B. E., et al. (2019) · SLEEP · doi:10.1093/sleep/zsz101 · Cited by 39 · see citing works
Behavior and sleep disturbance in Smith–Magenis syndrome
Shayota, B. J., & Elsea, S. H. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000474 · Cited by 40 · see citing works
Circadian disruption, melatonin rhythm perturbations and their contributions to chaotic physiology
Reiter, R. J., Rosales‐Corral, S., & Sharma, R. (2020) · Advances in Medical Sciences · doi:10.1016/j.advms.2020.07.001 · Cited by 41 · see citing works
Self-citationSpruyt, K., Braam, W., Smits, M. G., & Curfs, L. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12653 · Cited by 35 · see citing works
Dosage-sensitive genes in autism spectrum disorders: From neurobiology to therapy
Javed, S., Selliah, T., Lee, Y., & Huang, W. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.009 · Cited by 31 · see citing works
Mullegama, S. V., Pugliesi, L., Burns, B., Shah, Z., Tahir, R., Gu, Y., Nelson, D. L., & Elsea, S. H. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.200 · Cited by 33 · see citing works
Yin–Yang Actions of Histone Methylation Regulatory Complexes in the Brain
Garay, P. M., Wallner, M. A., & Iwase, S. (2016) · Epigenomics · doi:10.2217/epi-2016-0090 · Cited by 32 · see citing works
Smith-Magenis Syndrome: Molecular Basis of a Genetic-Driven Melatonin Circadian Secretion Disorder
Poisson, A., Nicolas, A., Bousquet, I., Raverot, V., Gronfier, C., & Demily, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143533 · Cited by 31 · see citing works
Lacaria, M., Gu, W., & Lupski, J. R. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35941 · Cited by 28 · see citing works
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Woodford, E. C., McLay, L., France, K. G., Blampied, N. M., Gibbs, R. M., Swan, C. E., & Eggleston, M. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101433 · Cited by 22 · see citing works
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Shaw, P. J., Tafti, M., & Thorpy, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.035 · Cited by 5 · see citing works
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Nijim, Y., Adawi, A., Bisharat, B., & Bowirrat, A. (2016) · Medicine · doi:10.1097/md.0000000000002362 · Cited by 5 · see citing works
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Alexiou, S., & Brooks, L. J. (2012) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2012.10.002 · Cited by 4 · see citing works
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Salehi, A. (2013) · InTech eBooks · doi:10.5772/56808 · Cited by 3 · see citing works
Weselake, S., & Wevrick, R. (2012) · Clinical Genetics · doi:10.1111/j.1399-0004.2012.01886.x · Cited by 2 · see citing works
Sironi, A., Bestetti, I., Masciadri, M., Tumiatti, F., Crippa, M., Pantaleoni, C., Russo, S., D’Arrigo, S., Milani, D., Larizza, L., et al. (2022) · European Journal of Human Genetics · doi:10.1038/s41431-022-01143-5 · Cited by 2 · see citing works
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Moretti‐Ferreira, D. (2013) · InTech eBooks · doi:10.5772/55721 · Cited by 1 · see citing works
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Xie, H., Linning‐Duffy, K., Demireva, E. Y., Toh, H., Abolibdeh, B., Shi, J., Zhou, B., Iwase, S., & Yan, L. (2024) · BMC Biology · doi:10.1186/s12915-024-01943-9 · Cited by 1 · see citing works
Garay, P. M. (2021) · Deep Blue (University of Michigan) · doi:10.7302/1431
Smieszek, S. P. (2024) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-024-00508-3
Treadwell‐Deering, D., Kaplan, K., & Potocki, L. (2024) · Springer eBooks · doi:10.1007/978-3-031-76269-7_15
Self-citationXie, H., Linning‐Duffy, K., Demireva, E. Y., Toh, H., Abolibdeh, B., Shi, J., Zhou, B., Iwase, S., & Yan, L. (2024) · Figshare · doi:10.6084/m9.figshare.26741621
Xie, H., Linning‐Duffy, K., Demireva, E. Y., Toh, H., Abolibdeh, B., Shi, J., Zhou, B., Iwase, S., & Yan, L. (2024) · Figshare · doi:10.6084/m9.figshare.26157142
Xie, H., Linning‐Duffy, K., Demireva, E. Y., Toh, H., Abolibdeh, B., Shi, J., Zhou, B., Iwase, S., & Yan, L. (2024) · Figshare · doi:10.6084/m9.figshare.26157552
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Lozano‐García, A., & González-Camacho, S. (2026) · Sleep and Biological Rhythms · doi:10.1007/s41105-026-00683-3
- Authors
- Boone, P. M., Reiter, R. J., Glaze, D. G., Tan, D., Lupski, J. R., & Potocki, L.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Potocki, Lorraine
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2011-07-07
- Volume
- 155
- Issue
- 8
- Pages
- 2024-2027
- ISSN
- 1552-4825 (ISSN-L)
- 1552-4833
- PMC
- PMC3140606
- OpenAlex
- W2078599571
- Cited by
- 47
- References
- 35
- Citations by year
- 2026: 4 · 2024: 7 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Medical Genetics Part A (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (T32EY00710, T32EY007102)
- National Institute of Neurological Disorders and Stroke (R01NS058529)
- National Center for Research Resources (M01RR000188, M01 RR-00188)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24064-02, K08 HD01149, K08HD001149)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- Smith-Magenis syndrome, RAI1 gene, point mutations, melatonin, circadian rhythm, circadian rhythm disorders, melatonin secretion
- MeSH terms
- Adult, Child, Circadian Rhythm, Female, Humans, Male, Melatonin, Sleep Stages, Transcription Factors, Trans-Activators, Point Mutation, Sleep Disorders, Circadian Rhythm, Genetic Association Studies, Smith-Magenis Syndrome
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