β1-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome
Open accessAbstract
Smith-Magenis syndrome (SMS) is a clinically recognisable contiguous gene syndrome ascribed to interstitial deletions of chromosome 17p11.2. Patients have a phase shift of their circadian rhythm of melatonin with a paradoxical diurnal secretion of the hormone. Serum melatonin levels and day-night behaviour were studied in nine SMS children (aged 4 to 17 years) given acebutolol, a selective β 1-adrenergic antagonist (10 mg/kg early in the morning). Cardiac examination, serum melatonin, motor activity recordings, and sleep diaries were monitored before and after drug administration. The present study shows that a single morning dose of acebutolol suppressed the inappropriate secretion of melatonin in SMS. A significant improvement of inappropriate behaviour with increased concentration, delayed sleep onset, increased hours of sleep, and delayed waking were also noted. These results suggest that β 1-adrenergic antagonists help to manage hyperactivity, enhance cognitive performance, and reduce sleep disorders in SMS.
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Attenuating the rise of melatonin during the morning via pharmacological antagonism of β1-adrenergic receptors by acebutolol has been effective for reducing daytime naps, improving concentration and reducing the frequency of tantrums in a sample of ten patients, aged 4-18 years.
“Attenuating the rise of melatonin during the morning via pharmacological antagonism of β1-adrenergic receptors by acebutolol (as pineal melatonin production is stimulated by sympathetic nervous system activation of β1- and α1-receptors) has been effective for reducing daytime naps, improving concentration and reducing the frequency of tantrums in a sample of ten patients, aged 4–18 years136.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [136]
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- Authors
- De Leersnyder, H., de Blois, M.-C., Vekemans, M., Sidi, D., Villain, E., Kindermans, C., & Munnich, A.
- Affiliations
- Hôpital Necker-Enfants Malades (FR)
- ORCID
- Vekemans, Michel
- Venue
- Journal of Medical Genetics
- Publisher
- BMJ
- Published
- 2001-09-01
- Volume
- 38
- Issue
- 9
- Pages
- 586-590
- ISSN
- 0022-2593 (ISSN-L)
- 1468-6244
- PMC
- PMC1734944
- OpenAlex
- W2160001540
- Cited by
- 113
- References
- 26
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 10 · 2012: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- Smith-Magenis syndrome, acebutolol, circadian rhythm, melatonin secretion, sleep disorders, sleep onset delay, behavioral problems, hyperactivity, chromosome 17p11.2 deletion, children
- MeSH terms
- Acebutolol, Adolescent, Adrenergic beta-Antagonists, Behavior, Child, Child, Preschool, Chromosomes, Human, Pair 17, Circadian Rhythm, Cognition, Female, Humans, Hyperkinesis, Male, Melatonin, Sleep, Sleep Wake Disorders, Syndrome, Wakefulness, In Situ Hybridization, Fluorescence, Chronobiology Disorders
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