Chronological age, but not FMRP levels, predicts neuropsychological performance in girls with fragile X syndrome
Open accessAbstract
The effect of FMRP levels and chronological age on executive functioning, visual‐spatial abilities ,and verbal fluency tasks were examined in 46 school‐age girls with fragile X syndrome (FXS). Results indicated that FMRP levels were not predictive of outcome on the neuropsychological tests but that performance on the executive functioning task tended to worsen with chronological age. This age effect was not observed on the tests of visual‐spatial abilities or verbal fluency. These data indicate that relative deficits in executive functioning in girls with FXS become more pronounced with age. In contrast, the relative deficits in spatial and verbal abilities of these girls did not appear to increase with age, suggesting that these abilities may be spared. © 2006 Wiley‐Liss, Inc.
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Specific areas of cognitive weaknesses in FXS include communication, mathematics, visual-spatial processing, executive function, and memory.
“Specific areas of cognitive weaknesses include communication, mathematics, visual-spatial processing, executive function, and memory [709-711].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [710]
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Self-citation
- Authors
- Lightbody, A. A., Hall, S. S., & Reiss, A. L.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Hall, Scott S.
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2006-06
- Volume
- 141B
- Issue
- 5
- Pages
- 468-472
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- PMC
- PMC2663575
- OpenAlex
- W1973607528
- Cited by
- 21
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2019: 4 · 2018: 2 · 2016: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-50047, MH01142, K02MH001142, R01MH050047)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- fragile X syndrome, executive function, visuospatial ability, verbal fluency, chronological age, age-related cognitive decline, girls, neuropsychological performance
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Fragile X Syndrome, Humans, Intelligence, Intelligence Tests, Male, Neuropsychological Tests, Predictive Value of Tests, Regression Analysis, Verbal Behavior, Visual Perception, Siblings, Fragile X Messenger Ribonucleoprotein 1
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