Cited by 21Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchWilliams Syndrome Research

Chronological age, but not FMRP levels, predicts neuropsychological performance in girls with fragile X syndrome

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Lightbody, Amy A., Hall, Scott S., Reiss, Allan L.·2006·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Abstract

The effect of FMRP levels and chronological age on executive functioning, visual‐spatial abilities ,and verbal fluency tasks were examined in 46 school‐age girls with fragile X syndrome (FXS). Results indicated that FMRP levels were not predictive of outcome on the neuropsychological tests but that performance on the executive functioning task tended to worsen with chronological age. This age effect was not observed on the tests of visual‐spatial abilities or verbal fluency. These data indicate that relative deficits in executive functioning in girls with FXS become more pronounced with age. In contrast, the relative deficits in spatial and verbal abilities of these girls did not appear to increase with age, suggesting that these abilities may be spared. © 2006 Wiley‐Liss, Inc.

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Crossref · 10.1002/ajmg.b.30307

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Authors
Lightbody, A. A., Hall, S. S., & Reiss, A. L.
Affiliations
Stanford Medicine (US)
Corresponding author
Hall, Scott S.
Venue
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publisher
Wiley
Published
2006-06
Volume
141B
Issue
5
Pages
468-472
ISSN
  • 1552-4841 (ISSN-L)
  • 1552-485X
OpenAlex
W1973607528
Cited by
21
References
34
Citations by year
2026: 1 · 2025: 1 · 2021: 1 · 2019: 4 · 2018: 2 · 2016: 1 · 2013: 3 · 2012: 2
FWCI
0.95
Type
journal article
Language
en
Open access
Locations
  • American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH-50047, MH01142, K02MH001142, R01MH050047)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
Keywords
fragile X syndrome, executive function, visuospatial ability, verbal fluency, chronological age, age-related cognitive decline, girls, neuropsychological performance
MeSH terms
Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Fragile X Syndrome, Humans, Intelligence, Intelligence Tests, Male, Neuropsychological Tests, Predictive Value of Tests, Regression Analysis, Verbal Behavior, Visual Perception, Siblings, Fragile X Messenger Ribonucleoprotein 1

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