Cited by 48Obsessive-Compulsive Spectrum DisordersHair Growth and DisordersPsychoanalysis and Psychopathology Research

A family study of trichotillomania and chronic hair pulling

Keuthen, Nancy J., Altenburger, Erin M., Pauls, David·2014·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Abstract

Little is known about the etiology of hair pulling (HP) and its relationship to other obsessive compulsive (OC) spectrum disorders. In a large-sample family study, we examined the familial aggregation of HP and co-transmission of obsessive compulsive disorder (OCD) and skin picking (SP). Our sample consisted of 110 proband cases with HP and 48 controls without HP, plus 128 first-degree case relatives and 50 first-degree control relatives. Case versus control relatives had higher recurrence risk estimates for both HP and OCD but not SP. The finding that HP is familial is consistent with the only existing twin study. Additional analyses suggest that there may be a familial subtype of HP with comorbid OCD. Those adult proband cases with HP + OCD had more anxiety and depression than cases without OCD. Probands with HP + OCD also had earlier onset of OCD. Identification of an HP subtype with comorbid OCD may have significant theoretical and treatment implications. The data did not provide evidence for an etiologic relationship between HP and SP. Replication of these findings in future studies with larger cohorts of case and control relatives is warranted.

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Crossref · 10.1002/ajmg.b.32218

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  • Keuthen et al. found that the relatives of probands with trichotillomania had higher recurrence risk estimates for hair pulling.

    “In a recent study, Keuthen et al. found that the relatives of probands with trichotillomania had higher recurrence risk estimates for hair pulling.[19]”

    From Trichotillomania (hair pulling disorder) (2019) · cites this paper as [19]

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Authors
Keuthen, N. J., Altenburger, E. M., & Pauls, D.
Affiliations
Harvard University (US)
Corresponding author
Keuthen, Nancy J.
Venue
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publisher
Wiley
Published
2014-01-10
Volume
165
Issue
2
Pages
167-174
ISSN
  • 1552-4841 (ISSN-L)
  • 1552-485X
OpenAlex
W1980003298
Cited by
48
References
42
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 6 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 4
FWCI
8.26
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Yale University
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
trichotillomania, hair pulling, obsessive-compulsive disorder, skin picking, familial aggregation, recurrence risk, comorbidities, obsessive-compulsive spectrum disorders, anxiety, depression, age of onset, genetic etiology
MeSH terms
Chronic Disease, Depressive Disorder, Family, Female, Humans, Male, Obsessive-Compulsive Disorder, Trichotillomania, Age of Onset, Risk Assessment, Genetic Predisposition to Disease

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