A family study of trichotillomania and chronic hair pulling
Abstract
Little is known about the etiology of hair pulling (HP) and its relationship to other obsessive compulsive (OC) spectrum disorders. In a large-sample family study, we examined the familial aggregation of HP and co-transmission of obsessive compulsive disorder (OCD) and skin picking (SP). Our sample consisted of 110 proband cases with HP and 48 controls without HP, plus 128 first-degree case relatives and 50 first-degree control relatives. Case versus control relatives had higher recurrence risk estimates for both HP and OCD but not SP. The finding that HP is familial is consistent with the only existing twin study. Additional analyses suggest that there may be a familial subtype of HP with comorbid OCD. Those adult proband cases with HP + OCD had more anxiety and depression than cases without OCD. Probands with HP + OCD also had earlier onset of OCD. Identification of an HP subtype with comorbid OCD may have significant theoretical and treatment implications. The data did not provide evidence for an etiologic relationship between HP and SP. Replication of these findings in future studies with larger cohorts of case and control relatives is warranted.
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Keuthen et al. found that the relatives of probands with trichotillomania had higher recurrence risk estimates for hair pulling.
“In a recent study, Keuthen et al. found that the relatives of probands with trichotillomania had higher recurrence risk estimates for hair pulling.[19]”
From Trichotillomania (hair pulling disorder) (2019) · cites this paper as [19]
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- Authors
- Keuthen, N. J., Altenburger, E. M., & Pauls, D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Keuthen, Nancy J.
- ORCID
- Keuthen, Nancy J.
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2014-01-10
- Volume
- 165
- Issue
- 2
- Pages
- 167-174
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W1980003298
- Cited by
- 48
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 6 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 4
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- trichotillomania, hair pulling, obsessive-compulsive disorder, skin picking, familial aggregation, recurrence risk, comorbidities, obsessive-compulsive spectrum disorders, anxiety, depression, age of onset, genetic etiology
- MeSH terms
- Chronic Disease, Depressive Disorder, Family, Female, Humans, Male, Obsessive-Compulsive Disorder, Trichotillomania, Age of Onset, Risk Assessment, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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