Genetics of obsessive-compulsive disorder and related disorders

Browne, Heidi A.; Gair, Shannon L.; Scharf, Jeremiah M.; Grice, Dorothy E.

doi:10.1016/j.psc.2014.06.002

Cited by 92Obsessive-Compulsive Spectrum DisordersPerfectionism, Procrastination, Anxiety StudiesPsychoanalysis and Psychopathology Research

Genetics of obsessive-compulsive disorder and related disorders

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Browne, Heidi A., Gair, Shannon L., Scharf, Jeremiah M., Grice, Dorothy E.·2014·Psychiatric Clinics of North America

DOI 10.1016/j.psc.2014.06.002PMC PMC4143777

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Abstract

Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

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Both genetic and environmental factors contribute to the risk of developing OCD.
“However, both genetic and environmental factors contribute to risk of developing OCD (11–17).”
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Authors: Browne, H. A., Gair, S. L., Scharf, J. M., & Grice, D. E.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Harvard University (US)
Corresponding author: Scharf, Jeremiah M.
Grice, Dorothy E.
ORCID: Gair, Shannon L.
Scharf, Jeremiah M.
Grice, Dorothy E.
Venue: Psychiatric Clinics of North America
Publisher: Elsevier BV
Published: 2014-09
Volume: 37
Issue: 3
Pages: 319-335
ISSN: 0193-953X (ISSN-L)
DOI: 10.1016/j.psc.2014.06.002
PMC: PMC4143777
OpenAlex: W1987911043
Cited by: 92
References: 93
Citations by year: 2025: 6 · 2024: 11 · 2023: 11 · 2022: 7 · 2021: 14 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 3
FWCI: 0.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatric Clinics of North America (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH092516)
National Institute of Neurological Disorders and Stroke (K02NS085048, U01NS40024, U01NS040024)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Clinical Psychology › Perfectionism, Procrastination, Anxiety Studies
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: obsessive-compulsive disorder, genetic susceptibility, heritability, twin studies, family studies, tic disorders, trichotillomania, skin picking disorder, body dysmorphic disorder, hoarding disorder, genome-wide association study, candidate gene association
MeSH terms: Animals, Chronic Disease, Disease Models, Animal, Diseases in Twins, Family Health, Tourette Syndrome, Humans, Obsessive-Compulsive Disorder, Recurrence, Tic Disorders, Trichotillomania, Genetic Association Studies, Body Dysmorphic Disorders

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