The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.
Association of chemosensory dysfunction and COVID‐19 in patients presenting with influenza‐like symptoms
Open accessAbstract
Background: Rapid spread of the severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID‐19) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in COVID‐19 may help facilitate screening and early isolation of cases. Methods: A single‐institution, cross‐sectional study evaluating patient‐reported symptoms with a focus on smell and taste was conducted using an internet‐based platform on adult subjects who underwent testing for COVID‐19. Logistic regression was employed to identify symptoms associated with COVID‐19 positivity. Results: A total of 1480 patients with influenza‐like symptoms underwent COVID‐19 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID‐19–positive patients and 203 of 1378 (15%) COVID‐19–negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of COVID‐19–positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of COVID‐19–negative patients ( p < 0.001). Smell and taste impairment were independently and strongly associated with COVID‐19 positivity (anosmia: adjusted odds ratio [aOR] 10.9; 95% CI, 5.08‐23.5; ageusia: aOR 10.2; 95% CI, 4.74‐22.1), whereas sore throat was associated with COVID‐19 negativity (aOR 0.23; 95% CI, 0.11‐0.50). Of patients who reported COVID‐19–associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness. Conclusion: In ambulatory individuals with influenza‐like symptoms, chemosensory dysfunction was strongly associated with COVID‐19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease‐related symptoms.
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“a symptom more specific to COVID‐19 infection is loss of taste and smell, in which loss of taste, or dysgeusia, occurs in approximately 88.8% of cases.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [297]
In the citing paper
“recovery from COVID-related anosmia often occurs over weeks (11, 17, 18)”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [18]
In the citing paper
“Any reasonable pathophysiological mechanism for COVID-19-associated anosmia must account for the high penetrance of smell disorders relative to endemic viruses (12, 91, 92), the apparent suddenness of smell loss that can precede the development of other symptoms (11, 13), and the transient nature of dysfunction in many patients (11, 17, 18); definitive identification of the disease mechanisms”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [18]
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Cites
Presumed Asymptomatic Carrier Transmission of COVID-19
Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D., Chen, L., & Wang, M. (2020) · JAMA · doi:10.1001/jama.2020.2565 · Cited by 4,496
Baig, A. M., Khaleeq, A., Ali, U., & Syeda, H. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00122 · Cited by 2,207 · cited 1×
“Early studies evaluating mechanisms of SARS-CoV2-mediated olfactory loss have suggested neurotrophic targeting of olfactory neurons versus infection of non-neural olfactory epithelial cells.(5,6) The short-lived Covid-19-related olfactory loss found in our study favors a model in which SARS-CoV2 targets the olfactory…”
ResultGiacomelli, A., Pezzati, L., Conti, F., Bernacchia, D., Siano, M., Oreni, L., Rusconi, S., Gervasoni, C., Ridolfo, A. L., Rizzardini, G., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa330 · Cited by 1,326 · cited 1×
“5); (3) statistically significant associations (p < 0.”
Identification of Viruses in Patients With Postviral Olfactory Dysfunction
Suzuki, M., Saito, K., Min, W., Vladau, C., Toida, K., Itoh, H., & Murakami, S. (2007) · The Laryngoscope · doi:10.1097/01.mlg.0000249922.37381.1e · Cited by 383 · cited 1×
“05); and (4) we prioritized “any symptoms” (eg, any symptoms reported during the entire disease period) over “presenting symptoms” (eg, initial symptoms of presentation) because we had no a priori hypothesis for the natural history of anosmia and thus believed that inputting “any symptoms” for our multivariate correla…”
BackgroundBoesveldt, S., Postma, E. M., Boak, D., Welge‐Lüessen, A., Schöpf, V., Mainland, J. D., Martens, J. R., Ngai, J., & Duffy, V. B. (2017) · Chemical Senses · doi:10.1093/chemse/bjx025 · Cited by 376
Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., den Berge, K. V., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.25.009084 · Cited by 306
Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak
Bagheri, S. H., Asghari, A., Farhadi, M., Shamshiri, A. R., Kabir, A., Kamrava, S. K., Jalessi, M., Mohebbi, A., Alizadeh, R., Honarmand, A. A., et al. (2020) · doi:10.1101/2020.03.23.20041889 · Cited by 179
Qiu, C., Cui, C., Hautefort, C., Haehner, A., Zhao, J. F., Yao, Q., Zeng, H., Nisenbaum, E. J., Liu, L., Zhao, Y., et al. (2020) · Otolaryngology · doi:10.1177/0194599820934376 · Cited by 171
Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia
Torabi, A., Mohammadbagheri, E., Dilmaghani, N. A., Bayat, A., Fathi, M., Vakili, K. G., Alizadeh, R., Rezaeimirghaed, O., Hajiesmaeili, M., Ramezani, M., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00249 · Cited by 168
Chung, T. W., Sridhar, S., Zhang, J., Chan, K., Li, H., Wong, F. K.-C., Ng, M., Tsang, R. K., Lee, A. C.-Y., Fan, Z., et al. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa199 · Cited by 106
Role of Olfaction in Human Health: A Focus on Coronaviruses
Jaime-Lara, R. B., Parma, V., Yan, C. H., Faraji, F., & Joseph, P. V. (2020) · Allergy & Rhinology · doi:10.1177/2152656720928245 · Cited by 7
Self-citationSamaranayake, L. P., Fakhruddin, K. S., & Panduwawala, C. (2020) · BDJ · doi:10.1038/s41415-020-1732-2 · Cited by 5
Flagged first, then by citations
1 of the 13 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Giacomelli A, Self‐reported olfactory and taste disorders in SARS‐CoV‐2 patients: a cross‐sectional study, Clin Infect Dis
Cited by
Sorted by citations
Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Van den Berge, K., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5801 · Cited by 1,198
International consensus statement on allergy and rhinology: rhinosinusitis 2021
Orlandi, R. R., Kingdom, T. T., Smith, T. L., Bleier, B. S., DeConde, A. S., Luong, A., Poetker, D. M., Soler, Z. M., Welch, K. C., Wise, S. K., et al. (2020) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22741 · Cited by 1,084
Self-citationSmell dysfunction: a biomarker for COVID‐19
Moein, S. T., Hashemian, S. M. R., Mansourafshar, B., Khorram‐Tousi, A., Tabarsi, P., & Doty, R. L. (2020) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22587 · Cited by 807
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T. (2020) · Otolaryngology · doi:10.1177/0194599820926473 · Cited by 637
“…Klopfenstein et al 29 5 Moderate Lechien et al 27 4 Moderate Mao et al 7 6 Moderate Moein et al 33 4 Moderate Vaira et al 23 9 High Yan et al 31 5 27,34,35 and the COVID 19 Anosmia Reporting Tool recently developed by the AAO HNS (face validity only), 15,16 is particularly interest ing and…”
BackgroundInfluential
Metadata
- Authors
- Yan, C. H., Faraji, F., Prajapati, D. P., Boone, C. E., & DeConde, A. S.
- Affiliations
- UC San Diego Health System (US)
- Corresponding author
- Yan, Carol H.
- Venue
- International Forum of Allergy & Rhinology
- Publisher
- Wiley
- Published
- 2020-06
- Volume
- 10
- Issue
- 7
- Pages
- 806-813
- ISSN
- 2042-6976 (ISSN-L)
- 2042-6984
- PMC
- PMC7262089
- OpenAlex
- W3015631092
- Cited by
- 754
- References
- 13
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 19 · 2023: 60 · 2022: 94 · 2021: 248 · 2020: 317
- FWCI
- 63.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Forum of Allergy & Rhinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Center for Advancing Translational Sciences (UL1TR001442)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Dermatology › Dermatological and COVID-19 studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, anosmia, ageusia, chemosensory dysfunction, flu-like symptoms, subclinical symptoms, symptom screening, sore throat, symptom resolution, virus transmission, asymptomatic transmission, outpatients, patient-reported symptoms, COVID-19 testing, COVID-19 isolation, COVID-19 recovery
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Adult, Aged, Aged, 80 and over, Olfaction Disorders, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Pneumonia, Viral, Taste Disorders, Prevalence, Coronavirus Infections, Young Adult, Pandemics
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