Refined carbohydrate-rich diet is associated with long-term risk of dementia and Alzheimer’s disease in apolipoprotein E ε4 allele carriers
Open accessAbstract
INTRODUCTION: In animal models, refined carbohydrates (RF) worsen Alzheimer's disease (AD). However, the long-term effects of high RF intake on the risk of dementia and AD are poorly described in epidemiological studies. Moreover, the interaction between RF and the apolipoprotein E ε4 allele (APOE-ε4) is unknown. Our study investigated whether RF-rich diets are associated with the risk of dementia and AD. METHODS: The glycemic load (GL) was quantified in 2777 elderly participants from the French Three-City Study to estimate RF intake. Then, the associations between GL and risk of dementia and AD, and the interaction with APOE-ε4 over a 12-year period were assessed using proportional hazards models. RESULTS: After adjustment for potential confounders, high afternoon-snack GL was associated with increased dementia and AD risk in APOE-ε4 carriers (hazard ratio = 1.27 [1.03-1.56]). DISCUSSION: This study highlights that RF-rich diets are a risk factor for dementia and AD in APOE-ε4 carriers.
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Sedentary lifestyles and bad dietary habits, such as consuming large amounts of carbs and saturated fats, are connected to increased AD risk.
“Furthermore, sedentary lifestyles and bad dietary habits, such as consuming large amounts of carbs and saturated fats, have been connected to an increased risk [54,55,56,57].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [54]
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“Furthermore, sedentary lifestyles and bad dietary habits, such as consuming large amounts of carbs and saturated fats, have been connected to an increased risk [54–57].”
Background
- Authors
- Gentreau, M., Chuy, V., Féart, C., Samieri, C., Ritchie, K., Raymond, M., Berticat, C., & Artero, S.
- Affiliations
- Inserm (FR)
- Université de Bordeaux (FR)
- ISEM University of Montpellier, CNRS, EPHE, IRD Montpellier France
- Centre National de la Recherche Scientifique (FR)
- Neuropsychiatry: Epidemiological & Clinical Research University of Montpellier, INSERM Montpellier France
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2020-06-07
- Volume
- 16
- Issue
- 7
- Pages
- 1043-1053
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W3032963823
- Cited by
- 50
- References
- 57
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 5 · 2021: 10 · 2020: 2
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Sanofi
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Fondation de France
- Agence Française de Sécurité Sanitaire des Produits de Santé
- Mutuelle Générale de l'Education Nationale
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- refined carbohydrates, glycemic load
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Dementia, Diet, Dietary Carbohydrates, Female, France, Genotype, Heterozygote, Humans, Male, Incidence, Apolipoprotein E4
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