Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Open accessAbstract
INTRODUCTION: The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. METHODS: Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). RESULTS: Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. DISCUSSION: In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.
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Hypercaloric diets, high in meat, carbohydrate and sugars intake and low in fish and vegetables, are associated with brain atrophy and cortical thickness.
“Also, cross-sectional studies have found positive associations between higher adherence to the MedDiet and larger brain volumes [96,97,98], cerebral connectivity [99], or fewer white matter lesions [100] at older ages, whereas hypercaloric diets, high in meat, carbohydrate and sugars intake and low in fish and vegetables contents, are associated with brain atrophy [94] and cortical thickness [101]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [101]
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- Authors
- Staubo, S. C., Aakre, J. A., Vemuri, P., Syrjanen, J. A., Mielke, M. M., Geda, Y. E., Kremers, W. K., Machulda, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., & Roberts, R. O.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Roberts, Rosebud O.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2016-07-23
- Volume
- 13
- Issue
- 2
- Pages
- 168-177
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC5259552
- OpenAlex
- W2505127413
- Cited by
- 147
- References
- 49
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 25 · 2022: 11 · 2021: 20 · 2020: 12 · 2019: 13 · 2018: 23 · 2017: 8 · 2016: 2
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (U01 AG006786, P50 AG016574, R01 AG011378, R01 AG041851)
- U.S. Department of Defense
- National Institute on Deafness and Other Communication Disorders
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Mediterranean diet, cortical thickness
- MeSH terms
- Aged, Aged, 80 and over, Cerebral Cortex, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Organ Size, Micronutrients, Diet, Mediterranean
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